741
Views
138
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Cyanobacteria and BMAA exposure from desert dust: A possible link to sporadic ALS among Gulf War veterans

, , , , &
Pages 109-117 | Received 22 Jul 2009, Accepted 26 Aug 2009, Published online: 25 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Paul Mehta, Jaime Raymond, Reshma Punjani, Moon Han, Theodore Larson, Wendy Kaye, Lorene M. Nelson, Barbara Topol, Oleg Muravov, Corina Genson & D. Kevin Horton. (2023) Prevalence of amyotrophic lateral sclerosis in the United States using established and novel methodologies, 2017. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 24:1-2, pages 108-116.
Read now
Elisa Longinetti, Elisabetta Pupillo, Chiara Belometti, Elisa Bianchi, Marco Poloni, Fang Fang & Ettore Beghi. (2022) Geographical clusters of amyotrophic lateral sclerosis and the Bradford Hill criteria. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 23:5-6, pages 329-343.
Read now
N. Chernoff, D. J. Hill, D. L. Diggs, B. D. Faison, B. M. Francis, J. R Lang, M. M. Larue, T.-T. Le, K. A. Loftin, J. N. Lugo, J. E. Schmid & W. M. Winnik. (2017) A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans. Journal of Toxicology and Environmental Health, Part B 20:4, pages 183-229.
Read now
Cristina Porojan, Simon M. Mitrovic, Darren C. J. Yeo & Ambrose Furey. (2016) Overview of the potent cyanobacterial neurotoxin β-methylamino-L-alanine (BMAA) and its analytical determination. Food Additives & Contaminants: Part A 33:10, pages 1570-1586.
Read now
Emanuela Testai, Simona Scardala, Susanna Vichi, Franca M. Buratti & Enzo Funari. (2016) Risk to human health associated with the environmental occurrence of cyanobacterial neurotoxic alkaloids anatoxins and saxitoxins. Critical Reviews in Toxicology 46:5, pages 385-419.
Read now
. (2015) Theme 11 ALS Pathogenesis and Neurotoxicity. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16:sup1, pages 186-205.
Read now
Walter G. Bradley, Amy R. Borenstein, Lorene M. Nelson, Geoffrey A. Codd, Barry H. Rosen, Elijah W. Stommel & Paul Alan Cox. (2013) Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases?. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:5-6, pages 325-333.
Read now
Tracie A. Caller, Nicholas C. Field, Jonathan W. Chipman, Xun Shi, Brent T. Harris & Elijah W. Stommel. (2012) Spatial clustering of amyotrophic lateral sclerosis and the potential role of BMAA. Amyotrophic Lateral Sclerosis 13:1, pages 25-32.
Read now

Articles from other publishers (130)

James S. Metcalf, Sandra Anne Banack & Paul Alan Cox. (2023) Cyanotoxin Analysis of Air Samples from the Great Salt Lake. Toxins 15:11, pages 659.
Crossref
Ryan D. Weeks, Sandra A. Banack, Shaunacee Howell, Preethi Thunga, James S. Metcalf, Adrian J. Green, Paul A. Cox & Antonio Planchart. (2023) The Effects of Long-term, Low-dose β-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish. Neurotoxicity Research 41:5, pages 481-495.
Crossref
Peter I. Parry, Astrid Lefringhausen, Conny Turni, Christopher J. Neil, Robyn Cosford, Nicholas J. Hudson & Julian Gillespie. (2023) ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA. Biomedicines 11:8, pages 2287.
Crossref
Rosario Vasta, S. Callegaro, S. Sgambetterra, S. Cabras, F. Di Pede, F. De Mattei, E. Matteoni, M. Grassano, A. Bombaci, G. De Marco, G. Fuda, G. Marchese, F. Palumbo, A. Canosa, L. Mazzini, F. De Marchi, C. Moglia, U. Manera, A. Chiò & A. Calvo. (2023) Presymptomatic geographical distribution of ALS patients suggests the involvement of environmental factors in the disease pathogenesis. Journal of Neurology.
Crossref
Daniel Q. Tong, Thomas E. Gill, William A. Sprigg, Robert Scott Van Pelt, Alexander A. Baklanov, Bridget Marie Barker, Jesse E. Bell, Juan Castillo, Santiago Gassó, Cassandra J. Gaston, Dale W. Griffin, Nicolas Huneeus, Ralph A. Kahn, Arunas P. Kuciauskas, Luis A. Ladino, Junran Li, Olga L. Mayol‐Bracero, Orion Z. McCotter, Pablo A. Méndez‐Lázaro, Pierpaolo Mudu, Slobodan Nickovic, Damian Oyarzun, Joseph Prospero, Graciela B. Raga, Amit U. Raysoni, Ling Ren, Nikias Sarafoglou, Andrea Sealy, Ziheng Sun & Ana Vukovic Vimic. (2023) Health and Safety Effects of Airborne Soil Dust in the Americas and Beyond. Reviews of Geophysics 61:2.
Crossref
Sini Skariah, Sara Abdul-Majid, Anthony G. Hay, Anushree Acharya, Noora Kano, Raghad Khalid Al-Ishaq, Paul de Figueiredo, Arum Han, Adrian Guzman, Soha Roger Dargham, Saad Sameer, Gi Eun Kim, Sabiha Khan, Priyamvada Pillai & Ali A. Sultan. (2023) Soil Properties Correlate with Microbial Community Structure in Qatari Arid Soils. Microbiology Spectrum 11:2.
Crossref
Giuseppe Stipa, Antonio Ancidoni, Nicola Vanacore & Guido Bellomo. (2023) Raw Water and ALS: A Unifying Hypothesis for the Environmental Agents Involved in ALS. Annals of Neurosciences 30:2, pages 124-132.
Crossref
Galina Nugumanova, Eugene D. Ponomarev, Sholpan Askarova, Elizaveta Fasler-Kan & Natasha S. Barteneva. (2023) Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases. Toxins 15:3, pages 233.
Crossref
Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby, Emmeline Lagrange, B. Zane Horowitz, Raquel Valdes Angues, Jacques Reis, Jean-Paul Vernoux, Cédric Raoul & William Camu. (2023) Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research. Frontiers in Neuroscience 17.
Crossref
Milena Shkodrova, Milena Mishonova, Mariela Chichova, Iliyana Sazdova, Bilyana Ilieva, Dilyana Doncheva-Stoimenova, Neli Raikova, Milena Keremidarska-Markova & Hristo Gagov. (2023) β-N-Methylamino-L-Alanine (BMAA) Modulates the Sympathetic Regulation and Homeostasis of Polyamines. Toxins 15:2, pages 141.
Crossref
Susanna P. Garamszegi, Sandra Anne Banack, Linda L. Duque, James S. Metcalf, Elijah W. Stommel, Paul Alan Cox & David A. Davis. (2023) Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study. Toxicology Reports 10, pages 87-96.
Crossref
Aidate Mussagy, Gloria Addico, Heléne Annadotter & Lindah Mhlanga. 2023. Lakes of Africa. Lakes of Africa 351 379 .
Srdjan Lopicic, Zorica Svirčev, Tamara Palanački Malešević, Aleksandar Kopitović, Aleksandra Ivanovska & Jussi Meriluoto. (2022) Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases. Microorganisms 10:12, pages 2418.
Crossref
Audrey Courtier, Damien Potheret & Patrizia Giannoni. (2022) Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk. Life Sciences 304, pages 120689.
Crossref
Diane B. Re, Beizhan Yan, Lilian Calderón-Garcidueñas, Angeline S. Andrew, Maeve Tischbein & Elijah W. Stommel. (2022) A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk. Journal of Neurology 269:5, pages 2359-2377.
Crossref
Melissa R. L. Whitaker, Florence Gilliéron, Christina Skirgaila, Mark C. Mescher & Consuelo M. De Moraes. (2022) Experimental evidence challenges the presumed defensive function of a “slow toxin” in cycads. Scientific Reports 12:1.
Crossref
James S. Metcalf, Rachael Anne Dunlop, Paul Alan Cox & Sandra Anne Banack. 2022. Handbook of Neurotoxicity. Handbook of Neurotoxicity 899 914 .
Maeve Tischbein & Elijah W. Stommel. 2022. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1007 1034 .
Maeve Tischbein & Elijah W. Stommel. 2021. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1 28 .
James S. Metcalf, Maeve Tischbein, Paul Alan Cox & Elijah W. Stommel. (2021) Cyanotoxins and the Nervous System. Toxins 13:9, pages 660.
Crossref
Hanan M. Al-Yousef & Musarat Amina. (2021) Phytoconstituents and pharmacological activities of cyanobacterium Fischerella ambigua. Arabian Journal of Chemistry 14:6, pages 103153.
Crossref
Georg Gӓrtner, Maya Stoyneva-Gӓrtner & Blagoy Uzunov. (2021) Algal Toxic Compounds and Their Aeroterrestrial, Airborne and other Extremophilic Producers with Attention to Soil and Plant Contamination: A Review. Toxins 13:5, pages 322.
Crossref
Paul Alan Cox. (2020) BMAA, Neurodegeneration, and Neuroprotection. Neurotoxicity Research 39:1, pages 1-5.
Crossref
Dunlop RA, Banack SA, Bishop SL, Metcalf JS, Murch SJ, Davis DA, Stommel EW, Karlsson O, Brittebo EB, Chatziefthimiou AD, Tan VX, Guillemin GG, Cox PA, Mash DC & Bradley WG. (2021) Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? A Response to a Critical Review of the BMAA Hypothesis. Neurotoxicity Research 39:1, pages 81-106.
Crossref
Aspassia D. Chatziefthimiou, Sandra Anne Banack & Paul Alan Cox. (2020) Biocrust-Produced Cyanotoxins Are Found Vertically in the Desert Soil Profile. Neurotoxicity Research 39:1, pages 42-48.
Crossref
James S. Metcalf, Rachael Anne Dunlop, Paul Alan Cox & Sandra Anne Banack. 2021. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1 16 .
Maeve Tischbein & Elijah W. Stommel. 2021. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1 28 .
J. S. Metcalf, A. D. Chatziefthimiou, N. R. Souza & P. A. Cox. 2021. The Arabian Seas: Biodiversity, Environmental Challenges and Conservation Measures. The Arabian Seas: Biodiversity, Environmental Challenges and Conservation Measures 161 178 .
Tamara Palanački Malešević, Tamara Dulić, Igor Obreht, Zorana Trivunović, Rastko Marković, Bojan Kostić, Tamara Važić, Jussi Meriluoto & Zorica Svirčev. (2020) Cyanobacterial Potential for Restoration of Loess Surfaces through Artificially Induced Biocrusts. Applied Sciences 11:1, pages 66.
Crossref
Geoffrey A. Codd, Emanuela Testai, Enzo Funari & Zorica Svirčev. 2020. Water Treatment for Purification from Cyanobacteria and Cyanotoxins. Water Treatment for Purification from Cyanobacteria and Cyanotoxins 37 68 .
Katherine E. A. Lewis, William Bennett, Christopher L. Blizzard, Adrian K. West, Roger S. Chung & Meng Inn Chuah. (2020) The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1 G93A amyotrophic lateral sclerosis mice . European Journal of Neuroscience 52:4, pages 3223-3241.
Crossref
Paula Pierozan, Elena Piras, Eva Brittebo & Oskar Karlsson. (2020) The cyanobacterial neurotoxin β-N-methylamino-l-alanine (BMAA) targets the olfactory bulb region. Archives of Toxicology 94:8, pages 2799-2808.
Crossref
Svetolik Spasic, Marija Stanojevic, Jelena Nesovic Ostojic, Sanjin Kovacevic, Jasna Todorovic, Marko Dincic, Vladimir Nedeljkov, Milica Prostran & Srdjan Lopicic. (2020) Two distinct electrophysiological mechanisms underlie extensive depolarization elicited by 2,4 diaminobutyric acid in leech Retzius neurons. Aquatic Toxicology 220, pages 105398.
Crossref
Stephanie L. Bishop & Susan J. Murch. (2020) A systematic review of analytical methods for the detection and quantification of β- N -methylamino- l -alanine (BMAA) . The Analyst 145:1, pages 13-28.
Crossref
N.R. Souza & J.S. Metcalf. 2020. Handbook of Algal Science, Technology and Medicine. Handbook of Algal Science, Technology and Medicine 561 574 .
P.S. Spencer, E. Lagrange & W. Camu. (2019) ALS and environment: Clues from spatial clustering?. Revue Neurologique 175:10, pages 652-663.
Crossref
Faraze A Niazi & Jack E Riggs. (2019) Association of ALS and Military Service: Reflection of Survival Bias due to the “Healthy Soldier Effect”?. Military Medicine.
Crossref
Jeremy E. Ellis, Dara S. Missan, Matthew Shabilla, Constantine Moschonas, David Saperstein, Delyn Martinez, Christian V. Becker & Stephen E. Fry. (2019) Comparison of the prokaryotic and eukaryotic microbial communities in peripheral blood from amyotrophic lateral sclerosis, multiple sclerosis, and control populations. Human Microbiome Journal 13, pages 100060.
Crossref
Mário U.G. Barros, Alan E. Wilson, João I.R. Leitão, Silvano P. Pereira, Riley P. Buley, Edna G. Fernandez-Figueroa & José Capelo-Neto. (2019) Environmental factors associated with toxic cyanobacterial blooms across 20 drinking water reservoirs in a semi-arid region of Brazil. Harmful Algae 86, pages 128-137.
Crossref
Jake P. Violi, Simon M. Mitrovic, Anne Colville, Brendan J. Main & Kenneth J. Rodgers. (2019) Prevalence of β-methylamino-L-alanine (BMAA) and its isomers in freshwater cyanobacteria isolated from eastern Australia. Ecotoxicology and Environmental Safety 172, pages 72-81.
Crossref
Rianita van Onselen & Tim G. Downing. (2019) β- N -methylamino-L-alanine Inhibits Human Catalase Activity: Possible Implications for Neurodegenerative Disease Development . International Journal of Toxicology 38:2, pages 129-134.
Crossref
Giusy Laudati, Luigi Mascolo, Natascia Guida, Rossana Sirabella, Vincenzo Pizzorusso, Sara Bruzzaniti, Angelo Serani, Gianfranco Di Renzo, Lorella M.T. Canzoniero & Luigi Formisano. (2019) Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway. NeuroToxicology 71, pages 6-15.
Crossref
Korina Manolidi, Theodoros M. Triantis, Triantafyllos Kaloudis & Anastasia Hiskia. (2019) Neurotoxin BMAA and its isomeric amino acids in cyanobacteria and cyanobacteria-based food supplements. Journal of Hazardous Materials 365, pages 346-365.
Crossref
Bo Li, Shanshan Yu, Gen Li, Xu Chen, Meng Huang, Xuewei Liao, Huixin Li, Feng Hu & Jun Wu. (2019) Transfer of a cyanobacterial neurotoxin, β-methylamino-l-alanine from soil to crop and its bioaccumulation in Chinese cabbage. Chemosphere 219, pages 997-1001.
Crossref
J.S. Metcalf & N.R. Souza. 2019. Evaluating Water Quality to Prevent Future Disasters. Evaluating Water Quality to Prevent Future Disasters 125 148 .
Megan Brooke-Jones, Martina Gáliková & Heinrich Dircksen. (2018) Cyanobacterial Neurotoxin Beta-Methyl-Amino-l-Alanine Affects Dopaminergic Neurons in Optic Ganglia and Brain of Daphnia magna. Toxins 10:12, pages 527.
Crossref
Ellen S. Pierce. (2018) How did Lou Gehrig get Lou Gehrig’s disease? Mycobacterium avium subspecies paratuberculosis in manure, soil, dirt, dust and grass and amyotrophic lateral sclerosis (motor neurone disease) clusters in football, rugby and soccer players. Medical Hypotheses 119, pages 1-5.
Crossref
Laura L. Scott, Simoné Downing & Tim Downing. (2018) Potential for dietary exposure to β-N-methylamino-L-alanine and microcystin from a freshwater system. Toxicon 150, pages 261-266.
Crossref
Brendan J. Main, Lee C. Bowling, Matthew P. Padula, David P. Bishop, Simon M. Mitrovic, Gilles J. Guillemin & Kenneth J. Rodgers. (2018) Detection of the suspected neurotoxin β-methylamino- l -alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia. Harmful Algae 74, pages 10-18.
Crossref
Brendan J. Main, Carly J. Italiano & Kenneth J. Rodgers. (2017) Investigation of the interaction of β-methylamino-l-alanine with eukaryotic and prokaryotic proteins. Amino Acids 50:3-4, pages 397-407.
Crossref
Anthony Laugeray, Asma Oummadi, Clément Jourdain, Justyne Feat, Géraldine Meyer-Dilhet, Arnaud Menuet, Karen Plé, Marion Gay, Sylvain Routier, Stéphane Mortaud & Gilles J. Guillemin. (2017) Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-l-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring—Potential Involvement of DNA Damage and Oxidative Stress. Neurotoxicity Research 33:1, pages 87-112.
Crossref
Fiona D. Mello, Nady Braidy, Helder Marçal, Gilles Guillemin, Seyed Mohammad Nabavi & Brett A. Neilan. (2017) Mechanisms and Effects Posed by Neurotoxic Products of Cyanobacteria/Microbial Eukaryotes/Dinoflagellates in Algae Blooms: a Review. Neurotoxicity Research 33:1, pages 153-167.
Crossref
Aspassia D. Chatziefthimiou, Eric J. Deitch, William B. Glover, James T. Powell, Sandra Anne Banack, Renee A. Richer, Paul A. Cox & James S. Metcalf. (2017) Analysis of Neurotoxic Amino Acids from Marine Waters, Microbial Mats, and Seafood Destined for Human Consumption in the Arabian Gulf. Neurotoxicity Research 33:1, pages 143-152.
Crossref
Brendan J. Main & Kenneth J. Rodgers. (2017) Assessing the Combined Toxicity of BMAA and Its Isomers 2,4-DAB and AEG In Vitro Using Human Neuroblastoma Cells. Neurotoxicity Research 33:1, pages 33-42.
Crossref
Kenneth J. Rodgers, Brendan J. Main & Kate Samardzic. (2017) Cyanobacterial Neurotoxins: Their Occurrence and Mechanisms of Toxicity. Neurotoxicity Research 33:1, pages 168-177.
Crossref
Paul Alan Cox, Richard M. Kostrzewa & Gilles J. Guillemin. (2017) BMAA and Neurodegenerative Illness. Neurotoxicity Research 33:1, pages 178-183.
Crossref
Laura Louise Scott, Simoné Downing & Timothy Grant Downing. (2017) The Evaluation of BMAA Inhalation as a Potential Exposure Route Using a rat Model. Neurotoxicity Research 33:1, pages 6-14.
Crossref
Nimaichand Salam, Zi-Wen Yang, Mipeshwaree Devi Asem, Wael N. Hozzein & Wen-Jun Li. 2018. Extremophiles in Eurasian Ecosystems: Ecology, Diversity, and Applications. Extremophiles in Eurasian Ecosystems: Ecology, Diversity, and Applications 365 387 .
Simoné Downing, Laura Scott, Nadezda Zguna & Timothy Downing. (2017) Human Scalp Hair as an Indicator of Exposure to the Environmental Toxin β-N-Methylamino-l-alanine. Toxins 10:1, pages 14.
Crossref
Jorge Regueiro, Noelia Negreira, Anxo Carreira-Casais, Conchi Pérez-Lamela & Jesús Simal-Gándara. (2017) Dietary exposure and neurotoxicity of the environmental free and bound toxin β- N -methylamino- l -alanine. Food Research International 100, pages 1-13.
Crossref
Samuel Cirés, María Casero & Antonio Quesada. (2017) Toxicity at the Edge of Life: A Review on Cyanobacterial Toxins from Extreme Environments. Marine Drugs 15:7, pages 233.
Crossref
Ming-Dong Wang, Julian Little, James Gomes, Neil R. Cashman & Daniel Krewski. (2017) Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. NeuroToxicology 61, pages 101-130.
Crossref
Daniella Gat, Yinon Mazar, Eddie Cytryn & Yinon Rudich. (2017) Origin-Dependent Variations in the Atmospheric Microbiome Community in Eastern Mediterranean Dust Storms. Environmental Science & Technology 51:12, pages 6709-6718.
Crossref
Kevin B. Boylan, Mark A. Ross & Eric J. Sorenson. 2017. Neurodegeneration. Neurodegeneration 137 160 .
Michal Pardo, Itzhak Katra, James J. Schaeur & Yinon Rudich. (2017) Mitochondria‐mediated oxidative stress induced by desert dust in rat alveolar macrophages. GeoHealth 1:1, pages 4-16.
Crossref
Fiona D‘Mello, Nady Braidy, Helder Marçal, Gilles Guillemin, Fanny Rossi, Mirielle Chinian, Dominique Laurent, Charles Teo & Brett A. Neilan. (2016) Cytotoxic Effects of Environmental Toxins on Human Glial Cells. Neurotoxicity Research 31:2, pages 245-258.
Crossref
Tamara Dulić, Jussi Meriluoto, Tamara Palanački Malešević, Violeta Gajić, Tamara Važić, Nada Tokodi, Igor Obreht, Bojan Kostić, Petar Kosijer, Farhad Khormali & Zorica Svirčev. (2017) Cyanobacterial diversity and toxicity of biocrusts from the Caspian Lowland loess deposits, North Iran. Quaternary International 429, pages 74-85.
Crossref
Sara Abdul Majid, Michael F. Graw, Aspassia D. Chatziefthimiou, Hanh Nguyen, Renee Richer, Michel Louge, Ali A. Sultan, Patrick Schloss & Anthony G. Hay. (2016) Microbial Characterization of Qatari Barchan Sand Dunes. PLOS ONE 11:9, pages e0161836.
Crossref
Matjaž Novak, Klara Hercog & Bojana Žegura. (2016) Assessment of the mutagenic and genotoxic activity of cyanobacterial toxin beta-N-methyl-amino-L-alanine in Salmonella typhimurium. Toxicon 118, pages 134-140.
Crossref
Aspassia D. Chatziefthimiou, James S. Metcalf, W. Broc Glover, Sandra A. Banack, Soha R. Dargham & Renee A. Richer. (2016) Cyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environments. Toxicon 114, pages 75-84.
Crossref
Claudia Figueroa-Romero, Junguk Hur, J. Simon Lunn, Ximena Paez-Colasante, Diane E. Bender, Raymond Yung, Stacey A. Sakowski & Eva L. Feldman. (2016) Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. Molecular and Cellular Neuroscience 71, pages 34-45.
Crossref
Damien Réveillon, Véronique Séchet, Philipp Hess & Zouher Amzil. (2016) Systematic detection of BMAA (β-N-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in mollusks collected in shellfish production areas along the French coasts. Toxicon 110, pages 35-46.
Crossref
Paul Alan Cox, David A. Davis, Deborah C. Mash, James S. Metcalf & Sandra Anne Banack. (2016) Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain. Proceedings of the Royal Society B: Biological Sciences 283:1823, pages 20152397.
Crossref
Dušan Šuput. 2016. Marine and Freshwater Toxins. Marine and Freshwater Toxins 239 258 .
Marc G. Weisskopf, Merit E. Cudkowicz & Norman Johnson. (2015) Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort. Epidemiology 26:6, pages 831-838.
Crossref
Graziella Rubino. (2015) Complex liaisons moving forward the Parkinson’s disease? An appraisal. Basal Ganglia 5:4, pages 77-87.
Crossref
Audrey Roy-Lachapelle, Morgan Solliec & Sébastien Sauvé. (2015) Determination of BMAA and three alkaloid cyanotoxins in lake water using dansyl chloride derivatization and high-resolution mass spectrometry. Analytical and Bioanalytical Chemistry 407:18, pages 5487-5501.
Crossref
Alexander S. Chiu, Nady Braidy, Helder Marçal, Jeffrey H. Welch, Michelle M. Gehringer, Gilles J. Guillemin & Brett A. Neilan. (2015) Global cellular responses to β-methyl-amino-l-alanine (BMAA) by olfactory ensheathing glial cells (OEC). Toxicon 99, pages 136-145.
Crossref
Sandra Lage, Heléne Annadotter, Ulla Rasmussen & Sara Rydberg. (2015) Biotransfer of β-N-Methylamino-l-alanine (BMAA) in a Eutrophicated Freshwater Lake. Marine Drugs 13:3, pages 1185-1201.
Crossref
Sandra Banack, Tracie Caller, Patricia Henegan, James Haney, Amanda Murby, James Metcalf, James Powell, Paul Cox & Elijah Stommel. (2015) Detection of Cyanotoxins, β-N-methylamino-L-alanine and Microcystins, from a Lake Surrounded by Cases of Amyotrophic Lateral Sclerosis. Toxins 7:2, pages 322-336.
Crossref
Maitham Ahmed Al-Sammak, Douglas G. Rogers & Kyle D. Hoagland. (2015) Acute β - N -Methylamino-L-alanine Toxicity in a Mouse Model . Journal of Toxicology 2015, pages 1-9.
Crossref
J.S. Metcalf, S.A. Banack, R. Richer & P.A. Cox. (2015) Neurotoxic amino acids and their isomers in desert environments. Journal of Arid Environments 112, pages 140-144.
Crossref
Renee Richer, Sandra Anne Banack, James S. Metcalf & Paul Alan Cox. (2015) The persistence of cyanobacterial toxins in desert soils. Journal of Arid Environments 112, pages 134-139.
Crossref
James T. Powell, Aspassia D. Chatziefthimiou, Sandra Anne Banack, Paul Alan Cox & James S. Metcalf. (2015) Desert crust microorganisms, their environment, and human health. Journal of Arid Environments 112, pages 127-133.
Crossref
John T. Greenamyre & Paul Barrett. 2015. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders 21 43 .
Dušan Šuput. 2014. Marine and Freshwater Toxins. Marine and Freshwater Toxins 1 16 .
Gabriella Caruso, Giorgia Caruso, Pasqualina Laganà Laganà, Antonino Santi Delia, Salvatore Parisi, Caterina Barone, Lucia Melcarne & Francesco MazzùAntonino Santi Delia, Gabriella Caruso, Lucia Melcarne, Giorgia Caruso, Salvatore Parisi & Pasqualina Laganà. 2015. Microbial Toxins and Related Contamination in the Food Industry. Microbial Toxins and Related Contamination in the Food Industry 13 55 .
Sandra Anne Banack, James S. Metcalf, Walter G. Bradley & Paul Alan Cox. (2014) Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida. Toxicon 90, pages 167-173.
Crossref
A. Delzor, P. Couratier, F. Boumediene, M. Nicol, M. Druet-Cabanac, F. Paraf, A. Mejean, O. Ploux, J.-P. Leleu, L. Brient, M. Lengronne, V. Pichon, A. Combes, S. El Abdellaoui, V. Bonneterre, E. Lagrange, G. Besson, D. J. Bicout, J. Boutonnat, W. Camu, N. Pageot, R. Juntas-Morales, V. Rigau, E. Masseret, E. Abadie, P.-M. Preux & B. Marin. (2014) Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme. BMJ Open 4:8, pages e005528-e005528.
Crossref
Elizabeth B. Moloney, Fred de Winter & Joost Verhaagen. (2014) ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease. Frontiers in Neuroscience 8.
Crossref
Caroline M. Tanner, Samuel M. Goldman, G. Webster Ross & Stephen J. Grate. (2014) The disease intersection of susceptibility and exposure: Chemical exposures and neurodegenerative disease risk. Alzheimer's & Dementia 10:3S.
Crossref
Aspassia D. Chatziefthimiou, Renee Richer, Hannah Rowles, James T. Powell & James S. Metcalf. (2014) Cyanotoxins as a potential cause of dog poisonings in desert environments. Veterinary Record 174:19, pages 484-485.
Crossref
Elisabeth Faassen. (2014) Presence of the Neurotoxin BMAA in Aquatic Ecosystems: What Do We Really Know?. Toxins 6:3, pages 1109-1138.
Crossref
Kenneth J. Rodgers. (2014) Non-protein amino acids and neurodegeneration: The enemy within. Experimental Neurology 253, pages 192-196.
Crossref
Simoné Downing, Valeska Contardo-Jara, Stephan Pflugmacher & Timothy Grant Downing. (2014) The fate of the cyanobacterial toxin β-N-methylamino-l-alanine in freshwater mussels. Ecotoxicology and Environmental Safety 101, pages 51-58.
Crossref
Maitham Al-Sammak, Kyle Hoagland, David Cassada & Daniel Snow. (2014) Co-occurrence of the Cyanotoxins BMAA, DABA and Anatoxin-a in Nebraska Reservoirs, Fish, and Aquatic Plants. Toxins 6:2, pages 488-508.
Crossref
W. Broc Glover & Susan J. Murch. 2014. Phytochemicals – Biosynthesis, Function and Application. Phytochemicals – Biosynthesis, Function and Application 149 174 .
Estelle Masseret, Sandra Banack, Farid Boumédiène, Eric Abadie, Luc Brient, Fabrice Pernet, Raoul Juntas-Morales, Nicolas Pageot, James Metcalf, Paul Cox & William Camu. (2013) Dietary BMAA Exposure in an Amyotrophic Lateral Sclerosis Cluster from Southern France. PLoS ONE 8:12, pages e83406.
Crossref
Maitham Ahmed Al-Sammak, Kyle D. Hoagland, Daniel D. Snow & David Cassada. (2013) Methods for simultaneous detection of the cyanotoxins BMAA, DABA, and anatoxin-a in environmental samples. Toxicon 76, pages 316-325.
Crossref
Rachael Anne Dunlop, Paul Alan Cox, Sandra Anne Banack & Kenneth John Rodgers. (2013) The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation. PLoS ONE 8:9, pages e75376.
Crossref
Estefanía de Munck, Emma Muñoz-Sáez, Begoña G. Miguel, M. Teresa Solas, Irene Ojeda, Ana Martínez, Carmen Gil & Rosa Mª Arahuetes. (2013) β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS. Environmental Toxicology and Pharmacology 36:2, pages 243-255.
Crossref
Francesca Trojsi, Maria Monsurrò & Gioacchino Tedeschi. (2013) Exposure to Environmental Toxicants and Pathogenesis of Amyotrophic Lateral Sclerosis: State of the Art and Research Perspectives. International Journal of Molecular Sciences 14:8, pages 15286-15311.
Crossref
Oliver Okle, Lisa Rath, C. Giovanni Galizia & Daniel R. Dietrich. (2013) The cyanobacterial neurotoxin beta-N-methylamino-l-alanine (BMAA) induces neuronal and behavioral changes in honeybees. Toxicology and Applied Pharmacology 270:1, pages 9-15.
Crossref
Zorica Svirčev, Slobodan B. Marković, Thomas Stevens, Geoffrey A. Codd, Ian Smalley, Jelica Simeunović, Igor Obreht, Tamara Dulić, Dijana Pantelić & Ulrich Hambach. (2013) Importance of biological loess crusts for loess formation in semi-arid environments. Quaternary International 296, pages 206-215.
Crossref
Audrey Combes, Saïda El Abdellaoui, Cédric Sarazin, Jérome Vial, Annick Mejean, Olivier Ploux & Valérie Pichon. (2013) Validation of the analytical procedure for the determination of the neurotoxin β-N-methylamino-l-alanine in complex environmental samples. Analytica Chimica Acta 771, pages 42-49.
Crossref
Elijah W. Stommel, Nicholas C. Field & Tracie A. Caller. (2013) Aerosolization of cyanobacteria as a risk factor for amyotrophic lateral sclerosis. Medical Hypotheses 80:2, pages 142-145.
Crossref
Liying Jiang, Eric Johnston, K. Magnus Åberg, Ulrika Nilsson & Leopold L. Ilag. (2012) Strategy for quantifying trace levels of BMAA in cyanobacteria by LC/MS/MS. Analytical and Bioanalytical Chemistry 405:4, pages 1283-1292.
Crossref
J.S. Metcalf, S.A. Banack, K. Kotut, L. Krienitz & G.A. Codd. (2013) Amino acid neurotoxins in feathers of the Lesser Flamingo, Phoeniconaias minor. Chemosphere 90:2, pages 835-839.
Crossref
Roberto E. Sica. (2012) Is amyotrophic lateral sclerosis a primary astrocytic disease?. Medical Hypotheses 79:6, pages 819-822.
Crossref
Joy J. Goto, Jane H. Koenig & Kazuo Ikeda. (2012) The physiological effect of ingested β-N-methylamino-L-alanine on a glutamatergic synapse in an in vivo preparation. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 156:3-4, pages 171-177.
Crossref
Moonhee Lee & Patrick L. McGeer. (2012) Weak BMAA toxicity compares with that of the dietary supplement beta-alanine. Neurobiology of Aging 33:7, pages 1440-1447.
Crossref
Oliver D. King, Aaron D. Gitler & James Shorter. (2012) The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Research 1462, pages 61-80.
Crossref
Liying Jiang, Benoit Aigret, Wim M. De Borggraeve, Zdenek Spacil & Leopold L. Ilag. (2012) Selective LC-MS/MS method for the identification of BMAA from its isomers in biological samples. Analytical and Bioanalytical Chemistry 403:6, pages 1719-1730.
Crossref
Mark W. Duncan. (2012) Good mass spectrometry and its place in good science. Journal of Mass Spectrometry 47:6, pages 795-809.
Crossref
J.S. Metcalf, R. Richer, P.A. Cox & G.A. Codd. (2012) Cyanotoxins in desert environments may present a risk to human health. Science of The Total Environment 421-422, pages 118-123.
Crossref
Wendee Holtcamp. (2012) The Emerging Science of BMAA: Do Cyanobacteria Contribute to Neurodegenerative Disease?. Environmental Health Perspectives 120:3.
Crossref
R. Richer, D. Anchassi, I. El-Assaad, M. El-Matbouly, F. Ali, I. Makki & J.S. Metcalf. (2012) Variation in the coverage of biological soil crusts in the State of Qatar. Journal of Arid Environments 78, pages 187-190.
Crossref
J.M. O’Neil, T.W. Davis, M.A. Burford & C.J. Gobler. (2012) The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change. Harmful Algae 14, pages 313-334.
Crossref
Steven A. Cohen. (2012) Analytical techniques for the detection of α-amino-β-methylaminopropionic acid. The Analyst 137:9, pages 1991.
Crossref
Rachel L. Redler & Nikolay V. Dokholyan. 2012. Molecular Biology of Neurodegenerative Diseases. Molecular Biology of Neurodegenerative Diseases 215 262 .
James S. Metcalf & Geoffrey A. Codd. 2012. Ecology of Cyanobacteria II. Ecology of Cyanobacteria II 651 675 .
Chunxiang Hu, Kunshan Gao & Brian A. Whitton. 2012. Ecology of Cyanobacteria II. Ecology of Cyanobacteria II 345 369 .
Nicholas C. Field, Tracie A. Caller & Elijah W. Stommel. (2011) An explanation for the changes in collagen in sporadic Amyotrophic Lateral Sclerosis. Medical Hypotheses 77:4, pages 565-567.
Crossref
Alexander S. Chiu, Michelle M. Gehringer, Jeffrey H. Welch & Brett A. Neilan. (2011) Does α-Amino-β-methylaminopropionic Acid (BMAA) Play a Role in Neurodegeneration?. International Journal of Environmental Research and Public Health 8:9, pages 3728-3746.
Crossref
Aiesha Ahmed & Matthew P. Wicklund. (2011) Amyotrophic Lateral Sclerosis: What Role Does Environment Play?. Neurologic Clinics 29:3, pages 689-711.
Crossref
P. K. Bienfang, S. V. DeFelice, E. A. Laws, L. E. Brand, R. R. Bidigare, S. Christensen, H. Trapido-Rosenthal, T. K. Hemscheidt, D. J. McGillicuddy, D. M. Anderson, H. M. Solo-Gabriele, A. B. Boehm & L. C. Backer. (2011) Prominent Human Health Impacts from Several Marine Microbes: History, Ecology, and Public Health Implications. International Journal of Microbiology 2011, pages 1-15.
Crossref
Sandra A. Banack, Tracie A. Caller & Elijah W. Stommel. (2010) The Cyanobacteria Derived Toxin Beta-N-Methylamino-L-Alanine and Amyotrophic Lateral Sclerosis. Toxins 2:12, pages 2837-2850.
Crossref
S.A. Banack, T.G. Downing, Z. Spácil, E.L. Purdie, J.S. Metcalf, S. Downing, M. Esterhuizen, G.A. Codd & P.A. Cox. (2010) Distinguishing the cyanobacterial neurotoxin β-N-methylamino-l-alanine (BMAA) from its structural isomer 2,4-diaminobutyric acid (2,4-DAB). Toxicon 56:6, pages 868-879.
Crossref
Laura R. Snyder, Jamin C. Hoggard, Thomas J. Montine & Robert E. Synovec. (2010) Development and application of a comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry method for the analysis of l-β-methylamino-alanine in human tissue. Journal of Chromatography A 1217:27, pages 4639-4647.
Crossref
Martin Welker & Ingrid Chorus. 2014. Handbuch Angewandte Limnologie: Grundlagen - Gewässerbelastung - Restaurierung - Aquatische Ökotoxikologie - Bewertung - Gewässerschutz. Handbuch Angewandte Limnologie: Grundlagen - Gewässerbelastung - Restaurierung - Aquatische Ökotoxikologie - Bewertung - Gewässerschutz 1 26 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.