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Amyotrophic Lateral Sclerosis Volume 11, 2010 - Issue 6
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Research Article

A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis

Nazem Atassi Massachusetts General HospitalCorrespondence[email protected]
,
Eva-Maria Ratai Massachusetts General Hospital
,
David J. Greenblatt Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, USA
,
Darlene Pulley Massachusetts General Hospital
,
Yanli Zhao Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, USA
,
Jeffery Bombardier Massachusetts General Hospital
,
Stuart Wallace Massachusetts General Hospital
,
Joanna Eckenrode Massachusetts General Hospital
,
Merit Cudkowicz Massachusetts General Hospital
&
Allitia Dibernardo Massachusetts General Hospital
 show all
Pages 508-513 | Received 17 Feb 2010, Accepted 22 Mar 2010, Published online: 11 Aug 2010

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Kay A. Lawton, Merit E. Cudkowicz, Meredith V. Brown, Danny Alexander, Rebecca Caffrey, Jacob E. Wulff, Robert Bowser, Robert Lawson, Matt Jaffa, Michael V. Milburn, John A. Ryals & James D. Berry. (2012) Biochemical alterations associated with ALS. Amyotrophic Lateral Sclerosis 13:1, pages 110-118.
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Maurits F. J. M. Vissers, Jules A. A. C. Heuberger & Geert Jan Groeneveld. (2021) Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders. International Journal of Molecular Sciences 22:4, pages 1615.
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Deborah L. de Guingand, Kirsten R. Palmer, Rodney J. Snow, Miranda L. Davies-Tuck & Stacey J. Ellery. (2020) Risk of Adverse Outcomes in Females Taking Oral Creatine Monohydrate: A Systematic Review and Meta-Analysis. Nutrients 12:6, pages 1780.
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Ojas SrivastavaChris HanstockSneha ChenjiDennell MahDean EurichDaniel TaPeter SeresCollin LukLorne ZinmanAgessandro AbrahaoSimon J. GrahamAngela GengeLawrence KorngutRichard FrayneSanjay Kalra. (2019) Cerebral degeneration in amyotrophic lateral sclerosis. Neurology Clinical Practice 9:5, pages 400-407.
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Sanjay Kalra. (2019) Magnetic Resonance Spectroscopy in ALS. Frontiers in Neurology 10.
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Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins & Pamela J. Shaw. (2019) Biomarkers in Motor Neuron Disease: A State of the Art Review. Frontiers in Neurology 10.
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Miguel Mazón, Juan Francisco Vázquez Costa, Amadeo Ten-Esteve & Luis Martí-Bonmatí. (2018) Imaging Biomarkers for the Diagnosis and Prognosis of Neurodegenerative Diseases. The Example of Amyotrophic Lateral Sclerosis. Frontiers in Neuroscience 12.
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Eman Alraddadi, Ryan Lillico, Jonathan Vennerstrom, Ted Lakowski & Donald Miller. (2018) Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth. Pharmaceutics 10:1, pages 31.
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Steven M. HerschGiovanni SchifittoDavid OakesAmy-Lee BredlauCatherine M. MeyersRichard NahinHerminia Diana Rosas. (2017) The CREST-E study of creatine for Huntington disease. Neurology 89:6, pages 594-601.
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Douglas G. Kondo, Lauren N. Forrest, Xianfeng Shi, Young-Hoon Sung, Tracy L. Hellem, Rebekah S. Huber & Perry F. Renshaw. (2016) Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression. Amino Acids 48:8, pages 1941-1954.
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Andreas Bender & Thomas Klopstock. (2016) Creatine for neuroprotection in neurodegenerative disease: end of story?. Amino Acids 48:8, pages 1929-1940.
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José M. García Santos, Alberto Inuggi, Joaquín Gómez Espuch, Carlos Vázquez, Francisca Iniesta, Miguel Blanquer, José María Moraleda & Salvador Martínez. (2016) Spinal cord infusion of stem cells in amyotrophic lateral sclerosis: Magnetic resonance spectroscopy shows metabolite improvement in the precentral gyrus. Cytotherapy 18:6, pages 785-796.
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Conceicao Moura Mirian, Rita Carvalho Garbi Novaes Maria, SSP Zago Yuri, Junio Eduardo Emanoel & Augusto Casulari Luiz. (2016) Efficacy and effectiveness of drug treatments in amyotrophic lateral sclerosis: A systematic review with meta-analysis. African Journal of Pharmacy and Pharmacology 10:13, pages 257-269.
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Chafic Y. Karam, Sabrina Paganoni, Nanette Joyce, Gregory T. Carter & Richard Bedlack. (2014) Palliative Care Issues in Amyotrophic Lateral Sclerosis. American Journal of Hospice and Palliative Medicine® 33:1, pages 84-92.
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Varan Govind. 2016. Magnetic Resonance Spectroscopy of Degenerative Brain Diseases. Magnetic Resonance Spectroscopy of Degenerative Brain Diseases 121 150 .
Richard S. Bedlack, Nanette Joyce, Gregory T. Carter, Sabrina Paganoni & Chafic Karam. (2015) Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis. Neurologic Clinics 33:4, pages 909-936.
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Adriano Chiò, Marco Pagani, Federica Agosta, Andrea Calvo, Angelina Cistaro & Massimo Filippi. (2014) Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes. The Lancet Neurology 13:12, pages 1228-1240.
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Xueping Chen, Xiaoyan Guo, Rui Huang, Zhenzhen Zheng, Yongping Chen & Hui-fang Shang. (2014) An exploratory study of serum creatinine levels in patients with amyotrophic lateral sclerosis. Neurological Sciences 35:10, pages 1591-1597.
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Ernesto Miquel, Adriana Cassina, Laura Martínez-Palma, José M. Souza, Carmen Bolatto, Sebastián Rodríguez-Bottero, Angela Logan, Robin A.J. Smith, Michael P. Murphy, Luis Barbeito, Rafael Radi & Patricia Cassina. (2014) Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis. Free Radical Biology and Medicine 70, pages 204-213.
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Lucie Ayach, Christophe Curti, Marc Montana, Pascale Pisano & Patrice Vanelle. (2013) Actualités dans le traitement étiologique de la sclérose latérale amyotrophique. Therapies 68:2, pages 93-106.
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Matthew Gladman, Merit Cudkowicz & Lorne Zinman. (2012) Enhancing clinical trials in neurodegenerative disorders. Current Opinion in Neurology 25:6, pages 735-742.
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Martin R TurnerFederica Agosta, Peter Bede, Varan Govind, Dorothée Lulé & Esther Verstraete. (2012) Neuroimaging in amyotrophic lateral sclerosis. Biomarkers in Medicine 6:3, pages 319-337.
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Maarten Schrooten, Wim Robberecht & Philip Van Damme. (2012) From El Escorial to Awaji: where do we go next with the amyotrophic lateral sclerosis criteria?. Neurodegenerative Disease Management 2:1, pages 135-140.
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Claire Henchcliffe & M. Flint Beal. 2012. Mitochondrial Dysfunction in Neurodegenerative Disorders. Mitochondrial Dysfunction in Neurodegenerative Disorders 215 230 .
James D Berry & Merit E Cudkowicz. (2011) New considerations in the design of clinical trials for amyotrophic lateral sclerosis. Clinical Investigation 1:10, pages 1375-1389.
Crossref
Lorne Zinman & Merit Cudkowicz. (2011) Emerging targets and treatments in amyotrophic lateral sclerosis. The Lancet Neurology 10:5, pages 481-490.
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