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Amyotrophic Lateral Sclerosis Volume 12, 2011 - Issue 1
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Research Article

Neurophysiological index as a biomarker for ALS progression: Validity of mixed effects models

Benjamin C. Cheah Neuroscience Research Australia, Sydney, New South Wales; Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
,
Steve Vucic Neuroscience Research Australia, Sydney, New South Wales
,
Arun V. Krishnan Neuroscience Research Australia, Sydney, New South Wales
,
Robert A. Boland Neuroscience Research Australia, Sydney, New South Wales
&
Matthew C. Kiernan Neuroscience Research Australia, Sydney, New South Wales; Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, AustraliaCorrespondence[email protected]
Pages 33-38 | Received 18 Jul 2010, Accepted 08 Oct 2010, Published online: 27 Jan 2011

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So Young Pyun, Yerim Kim, Seong-Il Oh & Jong Seok Bae. (2020) Differences in nerve excitability properties between isolated bulbar palsy and bulbar-dominant amyotrophic lateral sclerosis. Neurological Research 42:2, pages 133-140.
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Arens Taga & Nicholas J. Maragakis. (2018) Current and emerging ALS biomarkers: utility and potential in clinical trials. Expert Review of Neurotherapeutics 18:11, pages 871-886.
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Cláudia Santos Silva, Michael Swash & Mamede de Carvalho. (2023) Exploring the split hand phenomenon with the neurophysiological index. Neurophysiologie Clinique 53:4, pages 102864.
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Steve Vucic, Parvathi Menon, William Huynh, Colin Mahoney, Karen S. Ho, Alan Hartford, Austin Rynders, Jacob Evan, Jeremy Evan, Shelia Ligozio, Robert Glanzman, Michael T. Hotchkin & Matthew C. Kiernan. (2023) Efficacy and safety of CNM-Au8 in amyotrophic lateral sclerosis (RESCUE-ALS study): a phase 2, randomised, double-blind, placebo-controlled trial and open label extension. eClinicalMedicine 60, pages 102036.
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Yih-Chih Jacinta Kuo & Kai-Hsiang Stanley Chen. 2022. Respiratory Neurobiology: Physiology and Clinical Disorders, Part II. Respiratory Neurobiology: Physiology and Clinical Disorders, Part II 15 40 .
Andrea Barp, Andrea Lizio, Francesca Gerardi, Claudia Tarlarini, Luca Mauro, Valeria Ada Sansone & Christian Lunetta. (2021) Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression. Clinical Neurophysiology 132:7, pages 1564-1571.
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Huiyan Yu, Lu Chen, Shuo Zhang, Jing He & Dongsheng Fan. (2021) Early Axonal Dysfunction of the Peripheral Nervous System Influences Disease Progression of ALS: Evidence From Clinical Neuroelectrophysiology. Frontiers in Neurology 12.
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Federico Ranieri, Sara Mariotto, Raffaele Dubbioso & Vincenzo Di Lazzaro. (2021) Brain Stimulation as a Therapeutic Tool in Amyotrophic Lateral Sclerosis: Current Status and Interaction With Mechanisms of Altered Cortical Excitability. Frontiers in Neurology 11.
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Steve Vucic, Matthew C Kiernan, Parvathi Menon, William Huynh, Austin Rynders, Karen S Ho, Robert Glanzman & Michael T Hotchkin. (2021) Study protocol of RESCUE-ALS: A Phase 2, randomised, double-blind, placebo-controlled study in early symptomatic amyotrophic lateral sclerosis patients to assess bioenergetic catalysis with CNM-Au8 as a mechanism to slow disease progression. BMJ Open 11:1, pages e041479.
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E. Fileccia, S. De Pasqua, G. Rizzo, V. Di Stasi, V. Vacchiano, P. Avoni, I. Bartolomei, F. Pastorelli, R. Plasmati, V. Donadio, F. Salvi & R. Liguori. (2020) Denervation findings on EMG in amyotrophic lateral sclerosis and correlation with prognostic milestones: Data from a retrospective study. Clinical Neurophysiology 131:8, pages 2017-2022.
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J. Bashford, K. Mills & C. Shaw. (2020) The evolving role of surface electromyography in amyotrophic lateral sclerosis: A systematic review. Clinical Neurophysiology 131:4, pages 942-950.
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Carlo Civardi, Alessandra Collini, Letizia Mazzini, Francesco Monaco & Claudio Geda. (2019) Single‐pulse transcranial magnetic stimulation in amyotrophic lateral sclerosis. Muscle & Nerve 61:3, pages 330-337.
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James A Bashford, Aidan Wickham, Raquel Iniesta, Emmanuel M Drakakis, Martyn G Boutelle, Kerry R Mills & Chris E Shaw. (2020) The rise and fall of fasciculations in amyotrophic lateral sclerosis. Brain Communications 2:1.
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Emel Oguz Akarsu, Nermin Gorkem Sirin, Elif Kocasoy Orhan, Bahar Erbas, Hava Ozlem Dede, Mehmet Baris Baslo, Halil Atilla Idrisoglu & Ali Emre Oge. (2020) Repeater F-waves in amyotrophic lateral sclerosis: Electrophysiologic indicators of upper or lower motor neuron involvement?. Clinical Neurophysiology 131:1, pages 96-105.
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N. Gorkem Sirin, Emel Oguz Akarsu, Elif Kocasoy Orhan, Bahar Erbas, Tugrul Artug, H. Ozlem Dede, M. Baris Baslo, Halil A. Idrisoglu & A. Emre Oge. (2019) Parameters derived from compound muscle action potential scan for discriminating amyotrophic lateral sclerosis‐related denervation. Muscle & Nerve 60:4, pages 400-408.
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Michael Swash & Mamede de Carvalho. (2019) The ‘neurophysiological index’ predicts survival in amyotrophic lateral sclerosis. Clinical Neurophysiology 130:9, pages 1684-1685.
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Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins & Pamela J. Shaw. (2019) Biomarkers in Motor Neuron Disease: A State of the Art Review. Frontiers in Neurology 10.
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Rangariroyashe Hannah Chipika, Eoin Finegan, Stacey Li Hi Shing, Orla Hardiman & Peter Bede. (2019) Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS. Frontiers in Neurology 10.
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William Huynh, Thanuja Dharmadasa, Steve Vucic & Matthew C. Kiernan. (2019) Functional Biomarkers for Amyotrophic Lateral Sclerosis. Frontiers in Neurology 9.
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Steve Vucic & Seward B. Rutkove. (2018) Neurophysiological biomarkers in amyotrophic lateral sclerosis. Current Opinion in Neurology 31:5, pages 640-647.
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Marcio Luiz Escorcio‐Bezerra, Agessandro Abrahao, Karlo Faria Nunes, Nadia Iandoli De Oliveira Braga, Acary Souza Bulle Oliveira, Lorne Zinman & Gilberto Mastrocola Manzano. (2018) Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis. Muscle & Nerve 58:2, pages 204-212.
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Kazumoto Shibuya, Neil G. Simon, Nimeshan Geevasinga, Parvathi Menon, James Howells, Susanna B. Park, William Huynh, Yu-ichi Noto, Steve Vucic & Matthew C. Kiernan. (2017) The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis. Clinical Neurophysiology 128:6, pages 1075-1082.
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Kevin B. Boylan, Mark A. Ross & Eric J. Sorenson. 2017. Neurodegeneration. Neurodegeneration 137 160 .
Yuta Iwai, Kazumoto Shibuya, Sonoko Misawa, Yukari Sekiguchi, Keisuke Watanabe, Hiroshi Amino & Satoshi Kuwabara. (2016) Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis. PLOS ONE 11:7, pages e0158596.
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Mamede de Carvalho & Michael Swash. (2016) Lower motor neuron dysfunction in ALS. Clinical Neurophysiology 127:7, pages 2670-2681.
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Jean-Pascal Lefaucheur & Mamede de Carvalho. (2016) New insights into the clinical neurophysiological assessment of ALS. Neurophysiologie Clinique/Clinical Neurophysiology 46:3, pages 157-163.
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Kazumoto Shibuya, Susanna B. Park, Nimeshan Geevasinga, William Huynh, Neil G. Simon, Parvathi Menon, James Howells, Steve Vucic & Matthew C. Kiernan. (2016) Threshold tracking transcranial magnetic stimulation: Effects of age and gender on motor cortical function. Clinical Neurophysiology 127:6, pages 2355-2361.
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Mamede de Carvalho & Michael Swash. (2016) Fasciculation discharge frequency in amyotrophic lateral sclerosis and related disorders. Clinical Neurophysiology 127:5, pages 2257-2262.
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Michael Benatar, Kevin Boylan, Andreas Jeromin, Seward B. Rutkove, James Berry, Nazem Atassi & Lucie Bruijn. (2016) ALS biomarkers for therapy development: State of the field and future directions. Muscle & Nerve 53:2, pages 169-182.
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Mamede de Carvalho. (2015) Do We Have a Channel Solution for ALS?. EBioMedicine 2:12, pages 1842-1843.
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Jeffrey Rosenfeld & Michael J. Strong. (2015) Challenges in the Understanding and Treatment of Amyotrophic Lateral Sclerosis/Motor Neuron Disease. Neurotherapeutics 12:2, pages 317-325.
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Seward B. Rutkove. (2015) Clinical Measures of Disease Progression in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:2, pages 384-393.
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Sanjeev D. Nandedkar, Paul E. Barkhaus & Erik V. Stålberg. (2015) Cumulative Motor Index. Journal of Clinical Neurophysiology 32:1, pages 79-85.
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Neil G. Simon, Martin R. Turner, Steve Vucic, Ammar Al‐Chalabi, Jeremy Shefner, Catherine Lomen‐Hoerth & Matthew C. Kiernan. (2014) Quantifying disease progression in amyotrophic lateral sclerosis. Annals of Neurology 76:5, pages 643-657.
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Nataša Bizovičar, Jurij Dreo, Blaž Koritnik & Janez Zidar. (2014) Decreased movement-related beta desynchronization and impaired post-movement beta rebound in amyotrophic lateral sclerosis. Clinical Neurophysiology 125:8, pages 1689-1699.
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Sabrina Paganoni, Merit Cudkowicz & James D Berry. (2014) Outcome measures in amyotrophic lateral sclerosis clinical trials. Clinical Investigation 4:7, pages 605-618.
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Joshua Lee & Toshifumi Yokota. (2013) Antisense Therapy in Neurology. Journal of Personalized Medicine 3:3, pages 144-176.
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Steve Vucic, Cindy Shin-Yi Lin, Benjamin C. Cheah, Jenna Murray, Parvathi Menon, Arun V. Krishnan & Matthew C. Kiernan. (2013) Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis. Brain 136:5, pages 1361-1370.
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Martin R Turner, Orla Hardiman, Michael Benatar, Benjamin R Brooks, Adriano Chio, Mamede de Carvalho, Paul G Ince, Cindy Lin, Robert G Miller, Hiroshi Mitsumoto, Garth Nicholson, John Ravits, Pamela J Shaw, Michael Swash, Kevin Talbot, Bryan J Traynor, Leonard H Van den Berg, Jan H Veldink, Steve Vucic & Matthew C Kiernan. (2013) Controversies and priorities in amyotrophic lateral sclerosis. The Lancet Neurology 12:3, pages 310-322.
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David F. Garway-Heath, Gerassimos Lascaratos, Catey Bunce, David P. Crabb, Richard A. Russell & Ameet Shah. (2013) The United Kingdom Glaucoma Treatment Study. Ophthalmology 120:1, pages 68-76.
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Matthew Gladman, Merit Cudkowicz & Lorne Zinman. (2012) Enhancing clinical trials in neurodegenerative disorders. Current Opinion in Neurology 25:6, pages 735-742.
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Dan H Moore, Jonathan S Katz & Robert G Miller. (2011) A review of clinical trial designs in amyotrophic lateral sclerosis. Neurodegenerative Disease Management 1:6, pages 481-490.
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Mamede de Carvalho & Michael Swash. (2011) Amyotrophic lateral sclerosis. Current Opinion in Neurology 24:5, pages 497-503.
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