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Research Articles

Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: A phase I pilot study

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Pages 199-204 | Received 21 May 2012, Accepted 21 Aug 2012, Published online: 17 Sep 2012

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John P. Franklin, Mimoun Azzouz & Pamela J. Shaw. (2020) SOD1-targeting therapies for neurodegenerative diseases: a review of current findings and future potential. Expert Opinion on Orphan Drugs 8:10, pages 379-392.
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Michael BenatarJoanne WuuPeter M. AndersenNazem AtassiWilliam DavidMerit CudkowiczDavid Schoenfeld. (2018) Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS . Neurology 90:7.
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Loqman A. Mohamed, Shashirekha Markandaiah, Silvia Bonanno, Piera Pasinelli & Davide Trotti. (2017) Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The AAPS Journal 19:6, pages 1600-1614.
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Federica Rinaldi, Dario Motti, Laura Ferraiuolo & Brian K. Kaspar. (2017) High content analysis in amyotrophic lateral sclerosis. Molecular and Cellular Neuroscience 80, pages 180-191.
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Lucas T. Vu & Robert Bowser. (2016) Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis. Neurotherapeutics 14:1, pages 119-134.
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Kristi M. Anderson & R. Lee Mosley. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 681 711 .
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Mahlon A. Collins, Jiyan An, Brian L. Hood, Thomas P. Conrads & Robert P. Bowser. (2015) Label-Free LC–MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis. Journal of Proteome Research 14:11, pages 4486-4501.
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Nadine Bakkar, Ashley Boehringer & Robert Bowser. (2015) Use of biomarkers in ALS drug development and clinical trials. Brain Research 1607, pages 94-107.
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Xenia Kobeleva & Susanne Petri. (2013) Barriers to novel therapeutics in amyotrophic lateral sclerosis. Neurodegenerative Disease Management 3:6, pages 525-537.
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Allison S Limpert, Margrith E Mattmann & Nicholas D P Cosford. (2013) Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS). Beilstein Journal of Organic Chemistry 9, pages 717-732.
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