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Original Article

A randomized, double-blind, placebo-controlled study of flexible doses of levomilnacipran ER (40–120 mg/day) in patients with major depressive disorder

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Pages 10-19 | Accepted 09 Jan 2014, Published online: 16 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Renee-Marie Ragguett, Samantha J. Yim, Peter T. Ho & Roger S. McIntyre. (2017) Efficacy of levomilnacipran extended release in treating major depressive disorder. Expert Opinion on Pharmacotherapy 18:18, pages 2017-2024.
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Qunlian Huang, Xiaoyan Zhong, Ye Yun, Bin Yu & Yilan Huang. (2016) Efficacy and safety of multiple doses of levomilnacipran extended-release for the treatment of major depressive disorder. Neuropsychiatric Disease and Treatment 12, pages 2707-2714.
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Gregory M Asnis & Margaret A Henderson. (2015) Levomilnacipran for the treatment of major depressive disorder: a review. Neuropsychiatric Disease and Treatment 11, pages 125-135.
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Laishun Chen, William M Greenberg, Elimor Brand-Schieber, Julie Wangsa, Antonia Periclou & Parviz Ghahramani. (2015) Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans. Drug Design, Development and Therapy 9, pages 3293-3300.
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Valérie Brunner, Bernadette Maynadier, Laishun Chen, Louise Roques, Isabelle Hude, Sébastien Séguier, Laurence Barthe & Philippe Hermann. (2015) Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats. Drug Design, Development and Therapy 9, pages 3199-3215.
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William James Deardorff & George T Grossberg. (2014) A review of the clinical efficacy, safety and tolerability of the antidepressants vilazodone, levomilnacipran and vortioxetine. Expert Opinion on Pharmacotherapy 15:17, pages 2525-2542.
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Articles from other publishers (23)

Teresa Wiesinger, Stefanie Kremer, Tom Bschor & Christopher Baethge. (2023) Antidepressants and quality of life in patients with major depressive disorder – Systematic review and meta‐analysis of double‐blind, placebo‐controlled RCTs . Acta Psychiatrica Scandinavica 147:6, pages 545-560.
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Stefanie Kremer, Teresa Wiesinger, Tom Bschor & Christopher Baethge. (2023) Antidepressants and Social Functioning in Patients with Major Depressive Disorder: Systematic Review and Meta-Analysis of Double-Blind, Placebo-Controlled RCTs. Psychotherapy and Psychosomatics 92:5, pages 304-314.
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Kristin Waters. (2022) The clinical utility of newer antidepressant agents: Understanding the role in management of MDD. Mental Health Clinician 12:5, pages 309-319.
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Erick H. Turner, Andrea Cipriani, Toshi A. Furukawa, Georgia Salanti & Ymkje Anna de Vries. (2022) Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials. PLOS Medicine 19:1, pages e1003886.
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Christian P. Cheung, Mathura T. Thiyagarajah, Haben Y. Abraha, Celina S. Liu, Krista L. Lanctôt, Alex J. Kiss, Mahwesh Saleem, Ari Juda, Anthony J. Levitt, Ayal Schaffer, Amy H. Cheung & Mark Sinyor. (2021) The association between placebo arm inclusion and adverse event rates in antidepressant randomized controlled trials: An examination of the Nocebo Effect. Journal of Affective Disorders 280, pages 140-147.
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Mark Zimmerman, Caroline Balling, Iwona Chelminski & Kristy Dalrymple. (2020) Applying the inclusion/exclusion criteria in placebo-controlled studies to a clinical sample: A comparison of medications. Journal of Affective Disorders 260, pages 483-488.
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Tina H. Byun, Swarna S. Chaliki & Kenneth G. PooleJrJr. (2019) New Treatment Options for Depression: A Primer for Internists. The American Journal of Medicine 132:6, pages 678-684.
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Suresh Durgam, Changzheng Chen, Raffaele Migliore, Chandran Prakash & Michael E. Thase. (2019) Relapse prevention with levomilnacipran ER in adults with major depressive disorder: A multicenter, randomized, double-blind, placebo-controlled study. Depression and Anxiety 36:3, pages 225-234.
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Maria Bogdan, Eliza Gofita, Daniela Cornelia Calina, Adina Turcu-Stiolica, Anca Oana Docea, Tudor Adrian Balseanu, Adrian Camen, Gratiela Eliza Popa, Gabriela Rusu, Ina Cristofor, Liliana Pavel & Liliana Mititelu-Tartau. 2018. Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors. Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors.
Hairong He, Wei Wang, Jun Lyu, Jie Zheng, Liyang Guo, Xiaofang An, Yajuan Fan & Xiancang Ma. (2018) Efficacy and tolerability of different doses of three new antidepressants for treating major depressive disorder: A PRISMA-compliant meta-analysis. Journal of Psychiatric Research 96, pages 247-259.
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Michael E. Thase, Carl Gommoll, Changzheng Chen, Kenneth Kramer, Arif Khan & Suresh Durgam. (2017) Measures of suicidality in phase 3 clinical trials of levomilnacipran ER in adults with major depressive disorder. CNS Spectrums 22:6, pages 475-483.
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Kai G. Kahl, Mechthild Westhoff-Bleck & Tillmann H.C. Krüger. (2017) Effects of psychopharmacological treatment with antidepressants on the vascular system. Vascular Pharmacology 96-98, pages 11-18.
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David V. Sheehan, Kazuyuki Nakagome, Yuko Asami, Elizabeth A. Pappadopulos & Matthieu Boucher. (2017) Restoring function in major depressive disorder: A systematic review. Journal of Affective Disorders 215, pages 299-313.
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Pierre Blier, Carl Gommoll, Changzheng Chen & Kenneth Kramer. (2017) Effects of levomilnacipran ER on noradrenergic symptoms, anxiety symptoms, and functional impairment in adults with major depressive disorder: Post hoc analysis of 5 clinical trials. Journal of Affective Disorders 210, pages 273-279.
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Roger S. McIntyre, Carl Gommoll, Changzheng Chen & Adam Ruth. (2016) The efficacy of levomilnacipran ER across symptoms of major depressive disorder: a post hoc analysis of 5 randomized, double-blind, placebo-controlled trials. CNS Spectrums 21:5, pages 385-392.
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Susan G. Kornstein, Carl Gommoll, Changzheng Chen & Kenneth Kramer. (2016) The effects of levomilnacipran ER in adult patients with first-episode, highly recurrent, or chronic MDD. Journal of Affective Disorders 193, pages 137-143.
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Mark Zimmerman, Matthew Multach, Emily Walsh, Lia K. Rosenstein, Douglas Gazarian & Heather L. Clark. (2016) Problems in the Descriptions of the Psychiatric Inclusion and Exclusion Criteria in Publications of Antidepressant Efficacy Trials: A Qualitative Review and Recommendations for Improved Clarity. CNS Drugs 30:3, pages 185-191.
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Mark Zimmerman, Heather L. Clark, Matthew D. Multach, Emily Walsh, Lia K. Rosenstein & Douglas Gazarian. (2016) Inclusion/exclusion criteria in placebo-controlled studies of vortioxetine: Comparison to other antidepressants and implications for product labeling. Journal of Affective Disorders 190, pages 357-361.
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William James Deardorff & George T. Grossberg. (2015) The Pharmacology and Clinical Use of the Antidepressants Vilazodone, Levomilnacipran, and Vortioxetine for Depression in the Elderly. Current Geriatrics Reports 4:4, pages 301-311.
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Laishun Chen, Ramesh Boinpally, Nayra Gad, William M. Greenberg, Julie Wangsa, Antonia Periclou & Parviz Ghahramani. (2015) Evaluation of Cytochrome P450 (CYP) 3A4-Based Interactions of Levomilnacipran with Ketoconazole, Carbamazepine or Alprazolam in Healthy Subjects. Clinical Drug Investigation 35:10, pages 601-612.
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Laishun Chen, William M. Greenberg, Carl Gommoll, Joann O’Connor, Stephen R. Zukin, Antonia Periclou & Parviz Ghahramani. (2015) Levomilnacipran Pharmacokinetics in Healthy Volunteers Versus Patients with Major Depressive Disorder and Implications for Norepinephrine and Serotonin Reuptake Inhibition. Clinical Therapeutics 37:9, pages 2059-2070.
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Stuart A. Montgomery, Carl P. Gommoll, Changzheng Chen & William M. Greenberg. (2014) Efficacy of levomilnacipran extended-release in major depressive disorder: pooled analysis of 5 double-blind, placebo-controlled trials. CNS Spectrums 20:2, pages 148-156.
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Lesley J. Scott. (2014) Levomilnacipran Extended-Release: A Review of Its Use in Adult Patients with Major Depressive Disorder. CNS Drugs 28:11, pages 1071-1082.
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