Citations (57)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Arens Taga & Nicholas J. Maragakis. (2018) Current and emerging ALS biomarkers: utility and potential in clinical trials. Expert Review of Neurotherapeutics 18:11, pages 871-886.
Read now
Read now
Peggy Barschke, Patrick Oeckl, Petra Steinacker, Albert Ludolph & Markus Otto. (2017) Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosis. Expert Review of Proteomics 14:9, pages 769-777.
Read now
Read now
Margarida Gonçalves, Mamede De Carvalho, Cristina Peixoto, Paula Alves, Carmo Barreto, Abel Oliva, Susana Pinto, Ana Laborinho-Pronto, Marta Gromicho & Júlia Costa. (2017) Phosphoneurofilament heavy chain and vascular endothelial growth factor as cerebrospinal fluid biomarkers for ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18:1-2, pages 134-136.
Read now
Read now
Patrick Oeckl, Claude Jardel, François Salachas, Foudil Lamari, Peter M. Andersen, Robert Bowser, Mamede de Carvalho, Júlia Costa, Philip van Damme, Elizabeth Gray, Julian Grosskreutz, María Hernández-Barral, Sanna-Kaisa Herukka, André Huss, Andreas Jeromin, Janine Kirby, Magdalena Kuzma-Kozakiewicz, Maria del Mar Amador, Jesús S. Mora, Claudia Morelli, Petra Muckova, Susanne Petri, Koen Poesen, Heidrun Rhode, Anna-Karin Rikardsson, Wim Robberecht, Ana I. Rodríguez Mahillo, Pamela Shaw, Vincenzo Silani, Petra Steinacker, Martin R. Turner, Erdem Tüzün, Berrak Yetimler, Albert C. Ludolph & Markus Otto. (2016) Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 17:5-6, pages 404-413.
Read now
Read now
H. Blasco, P. Vourc’h, P. F. Pradat, P. H. Gordon, C. R. Andres & P. Corcia. (2016) Further development of biomarkers in amyotrophic lateral sclerosis. Expert Review of Molecular Diagnostics 16:8, pages 853-868.
Read now
Read now
Kay A. Lawton, Meredith V. Brown, Danny Alexander, Zhen Li, Jacob E. Wulff, Robert Lawson, Matt Jaffa, Mike V. Milburn, John A. Ryals, Robert Bowser, Merit E. Cudkowicz & James D. Berry. (2014) Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 15:5-6, pages 362-370.
Read now
Read now
Articles from other publishers (51)
Lucas Vu, Krystine Garcia‐Mansfield, Antonio Pompeiano, Jiyan An, Victoria David‐Dirgo, Ritin Sharma, Vinisha Venugopal, Harkeerat Halait, Guido Marcucci, Ya‐Huei Kuo, Lisa Uechi, Russell C. Rockne, Patrick Pirrotte & Robert Bowser. (2023)
Proteomics and mathematical modeling of longitudinal
CSF
differentiates fast versus slow
ALS
progression
. Annals of Clinical and Translational Neurology 10:11, pages 2025-2042.
Crossref
Crossref
Sandeep C Pingle, Feng Lin, Misa S Anekoji, C Pawan K Patro, Souvik Datta, Lawrence D Jones, Santosh Kesari & Shashaanka Ashili. (2023) Exploring the role of cerebrospinal fluid as analyte in neurologic disorders. Future Science OA 9:4.
Crossref
Crossref
Lan Zhou, Dongyue Lin, Guihua Xu, Xiaoyi Wang, Zilin Chen, Dingding Wang & Huiya Fan. (2023) Alteration of neurofilament heavy chain and its phosphoforms reveals early subcellular damage beyond the optic nerve head in glaucoma. Frontiers in Neurology 14.
Crossref
Crossref
Kateřina Klíčová & Jan Mareš. (2023) Molecular and cellular biology of amyotrophic lateral sclerosis. Neurologie pro praxi 24:1, pages 50-53.
Crossref
Crossref
A. N. Khabibrakhmanov, M. A. Mukhamedyarov & E. I. Bogdanov. (2023) Biomarkers for Amyotrophic Lateral Sclerosis. Neuroscience and Behavioral Physiology.
Crossref
Crossref
Francesca Vignaroli, Angelica Mele, Giacomo Tondo, Veronica De Giorgis, Marcello Manfredi, Cristoforo Comi, Letizia Mazzini & Fabiola De Marchi. (2023) The Need for Biomarkers in the ALS–FTD Spectrum: A Clinical Point of View on the Role of Proteomics. Proteomes 11:1, pages 1.
Crossref
Crossref
Sandra Anne Banack, Rachael Anne Dunlop, Elijah W. Stommel, Paul Mehta & Paul Alan Cox. (2022) miRNA extracted from extracellular vesicles is a robust biomarker of amyotrophic lateral sclerosis. Journal of the Neurological Sciences 442, pages 120396.
Crossref
Crossref
Ellie Sturmey & Andrea Malaspina. (2022)
Blood biomarkers in
ALS
: challenges, applications and novel frontiers
. Acta Neurologica Scandinavica 146:4, pages 375-388.
Crossref
Crossref
Hiroshi Mitsumoto, Edward J. Kasarskis & Zachary Simmons. (2022) Hastening the Diagnosis of Amyotrophic Lateral Sclerosis. Neurology 99:2, pages 60-68.
Crossref
Crossref
Chiara Zecca, Maria Teresa Dell’Abate, Giuseppe Pasculli, Rosa Capozzo, Roberta Barone, Serena Arima, Alessio Pollice, Vincenzo Brescia, Rosanna Tortelli & Giancarlo Logroscino. (2022) Role of plasma phosphorylated neurofilament heavy chain (pNfH) in amyotrophic lateral sclerosis. Journal of Cellular and Molecular Medicine 26:13, pages 3608-3615.
Crossref
Crossref
Julia Doroszkiewicz, Magdalena Groblewska & Barbara Mroczko. (2022) Molecular Biomarkers and Their Implications for the Early Diagnosis of Selected Neurodegenerative Diseases. International Journal of Molecular Sciences 23:9, pages 4610.
Crossref
Crossref
Irene Rojas-Núñez, Adriana Morales Gomez, Emily K Selland, Theresa Oduol, Stephanie Wolf, Scott Palmer & Hussni O. Mohammed. (2022) Levels of Serum Phosphorylated Neurofilament Heavy Subunit in Clinically Healthy Standardbred Horses. Journal of Equine Veterinary Science 110, pages 103861.
Crossref
Crossref
A.N. Khabibrakhmanov, M.A. Mukhamedyarov & E.I. Bogdanov. (2022) Biomarkers of amyotrophic lateral sclerosis. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 122:5, pages 30.
Crossref
Crossref
Jiaying Shi, Xiaohui Qin, Xueli Chang, Hong Wang, Junhong Guo & Wei Zhang. (2021) Neurofilament markers in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Journal of Cellular and Molecular Medicine 26:2, pages 583-587.
Crossref
Crossref
Elisabetta Zucchi, Valentina Bonetto, Gianni Sorarù, Ilaria Martinelli, Piero Parchi, Rocco Liguori & Jessica Mandrioli. (2020) Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers. Molecular Neurodegeneration 15:1.
Crossref
Crossref
Michael S. Bereman, Kaylie I. Kirkwood, Tharani Sabaretnam, Sarah Furlong, Dominic B. Rowe, Gilles J. Guillemin, Allyson L. Mellinger & David C. Muddiman. (2020)
Metabolite Profiling Reveals Predictive Biomarkers and the Absence of β-Methyl Amino-
l
-alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis
. Journal of Proteome Research 19:8, pages 3276-3285.
Crossref
Crossref
Stefanie Nicole Hayer, Inga Liepelt, Christian Barro, Carlo Wilke, Jens Kuhle, Peter Martus & Ludger Schöls. (2020) NfL and pNfH are increased in Friedreich’s ataxia. Journal of Neurology 267:5, pages 1420-1430.
Crossref
Crossref
Brian A Gordon. (2020) Neurofilaments in disease: what do we know?. Current Opinion in Neurobiology 61, pages 105-115.
Crossref
Crossref
Ryann M. Fame, Christian Cortés‐Campos & Hazel L. Sive. (2020) Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube. BioEssays 42:3.
Crossref
Crossref
Andreas Totzeck, Benjamin Stolte, Kathrin Kizina, Saskia Bolz, Melina Schlag, Andreas Thimm, Christoph Kleinschnitz & Tim Hagenacker. (2019) Neurofilament Heavy Chain and Tau Protein Are Not Elevated in Cerebrospinal Fluid of Adult Patients with Spinal Muscular Atrophy during Loading with Nusinersen. International Journal of Molecular Sciences 20:21, pages 5397.
Crossref
Crossref
Federico Verde, Vincenzo Silani & Markus Otto. (2019) Neurochemical biomarkers in amyotrophic lateral sclerosis. Current Opinion in Neurology 32:5, pages 747-757.
Crossref
Crossref
Petra Steinacker, Peggy Barschke & Markus Otto. (2019) Biomarkers for diseases with TDP-43 pathology. Molecular and Cellular Neuroscience 97, pages 43-59.
Crossref
Crossref
Elena Ikenberg, Peter Reilich, Angela Abicht, Corina Heller, Benedikt Schoser & Maggie C. Walter. (2019) Charcot-Marie-Tooth disease type 2CC due to a frameshift mutation of the neurofilament heavy polypeptide gene in an Austrian family. Neuromuscular Disorders 29:5, pages 392-397.
Crossref
Crossref
Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins & Pamela J. Shaw. (2019) Biomarkers in Motor Neuron Disease: A State of the Art Review. Frontiers in Neurology 10.
Crossref
Crossref
Ewa Laskowska, Dorota Kuczyńska-Wiśnik & Barbara Lipińska. (2019) Proteomic analysis of protein homeostasis and aggregation. Journal of Proteomics 198, pages 98-112.
Crossref
Crossref
Débora Lanznaster, Denis Reis de Assis, Philippe Corcia, Pierre-François Pradat & Hélène Blasco. (2018) Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS. Frontiers in Neurology 9.
Crossref
Crossref
Danae Campos-Melo, Zachary C. E. Hawley & Michael J. Strong. (2018) Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs. Molecular Brain 11:1.
Crossref
Crossref
Moritz Oberstadt, Joseph Claßen, Thomas Arendt & Max Holzer. (2017) TDP-43 and Cytoskeletal Proteins in ALS. Molecular Neurobiology 55:4, pages 3143-3151.
Crossref
Crossref
Daniela Rossi, Paolo Volanti, Liliana Brambilla, Tiziana Colletti, Rossella Spataro & Vincenzo La Bella. (2018) CSF neurofilament proteins as diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis. Journal of Neurology 265:3, pages 510-521.
Crossref
Crossref
Anne Vejux, Amira Namsi, Thomas Nury, Thibault Moreau & Gérard Lizard. (2018) Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols. Frontiers in Molecular Neuroscience 11.
Crossref
Crossref
Lawrence S. Goldstein & Utpal Das. 2018. The Molecular and Cellular Basis of Neurodegenerative Diseases. The Molecular and Cellular Basis of Neurodegenerative Diseases
345
367
.
Alastair Wilkins. 2018. Progressive Multiple Sclerosis. Progressive Multiple Sclerosis
71
92
.
Koen PoesenMaxim De SchaepdryverBeatrice StubendorffBenjamin GillePetra MuckovaSindy WendlerTino PrellThomas M. RingerHeidrun RhodeOlivier StevensKristl G. ClaeysGoedele CouwelierAnn D'HondtNikita LamairePetra TilkinDimphna Van ReijenSarah GourmaudNadin FedtkeBianka HeilingMatthias RumpelAnnekathrin RödigerAnne GunkelOtto W. WitteClaire PaquetRik VandenbergheJulian GrosskreutzPhilip Van Damme. (2017) Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease. Neurology 88:24, pages 2302-2309.
Crossref
Crossref
Stephanie R. ShepheardJoanne WuuMichell CardosoLuke WiklendtPhil G. DinningTim ChatawayDavid SchultzMichael BenatarMary-Louise Rogers. (2017)
Urinary p75
ECD
. Neurology 88:12, pages 1137-1143.
Crossref
Crossref
Mark Kindy, Paul Lupinacci, Raymond Chau, Tony Shum & Dorothy Ko. (2017) A Phase 2A randomized, double-blind, placebo-controlled pilot trial of GM604 in patients with Amyotrophic Lateral Sclerosis (ALS Protocol GALS-001) and a single compassionate patient treatment (Protocol GALS-C). F1000Research 6, pages 230.
Crossref
Crossref
Lucas T. Vu & Robert Bowser. (2016) Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis. Neurotherapeutics 14:1, pages 119-134.
Crossref
Crossref
Hristelina Ilieva & Nicholas J. Maragakis. 2017. Neurodegenerative Diseases. Neurodegenerative Diseases
191
210
.
Andreas Jeromin & Robert Bowser. 2017. Neurodegenerative Diseases. Neurodegenerative Diseases
491
528
.
Xueping Chen, Yongping Chen, Qianqian Wei, Ruwei Ou, Bei Cao, Bi Zhao & Hui-Fang Shang. (2016) Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis. BMC Neurology 16:1.
Crossref
Crossref
Dawei Li, Dongchao Shen, Hongfei Tai & Liying Cui. (2016) Neurofilaments in CSF As Diagnostic Biomarkers in Motor Neuron Disease: A Meta-Analysis. Frontiers in Aging Neuroscience 8.
Crossref
Crossref
Júlia Costa & Mamede de Carvalho. (2016) Emerging molecular biomarker targets for amyotrophic lateral sclerosis. Clinica Chimica Acta 455, pages 7-14.
Crossref
Crossref
Michael Benatar, Kevin Boylan, Andreas Jeromin, Seward B. Rutkove, James Berry, Nazem Atassi & Lucie Bruijn. (2016) ALS biomarkers for therapy development: State of the field and future directions. Muscle & Nerve 53:2, pages 169-182.
Crossref
Crossref
Paula I. Fuller-Carter, Kim W. Carter, Denise Anderson, Alan R. Harvey, Keith M. Giles & Jennifer Rodger. (2015) Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration. BMC Genomics 16:1.
Crossref
Crossref
Juliana Redondo, Kevin Kemp, Kelly Hares, Claire Rice, Neil Scolding & Alastair Wilkins. (2015) Purkinje Cell Pathology and Loss in Multiple Sclerosis Cerebellum. Brain Pathology 25:6, pages 692-700.
Crossref
Crossref
P.A. McCombe, C. Pfluger, P. Singh, C.Y.H. Lim, C. Airey & R.D. Henderson. (2015) Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis. Journal of the Neurological Sciences 353:1-2, pages 122-129.
Crossref
Crossref
Nadine Bakkar, Ashley Boehringer & Robert Bowser. (2015) Use of biomarkers in ALS drug development and clinical trials. Brain Research 1607, pages 94-107.
Crossref
Crossref
Wint Nandar, Elizabeth B. Neely, Zachary Simmons & James R. Connor. (2014) H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:12, pages 2413-2426.
Crossref
Crossref
Stephanie R. Shepheard, Tim Chataway, David W. Schultz, Robert A. Rush & Mary-Louise Rogers. (2014) The Extracellular Domain of Neurotrophin Receptor p75 as a Candidate Biomarker for Amyotrophic Lateral Sclerosis. PLoS ONE 9:1, pages e87398.
Crossref
Crossref
Laura Robelin & Jose Luis Gonzalez De Aguilar. (2014) Blood Biomarkers for Amyotrophic Lateral Sclerosis: Myth or Reality?. BioMed Research International 2014, pages 1-11.
Crossref
Crossref
Sanna Neselius, Henrik Zetterberg, Kaj Blennow, Jan Marcusson & Helena Brisby. (2013) Increased CSF Levels of Phosphorylated Neurofilament Heavy Protein following Bout in Amateur Boxers. PLoS ONE 8:11, pages e81249.
Crossref
Crossref
G Huang, X Lee, Y Bian, Z Shao, G Sheng, R B Pepinsky & S Mi. (2013) Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis. Cell Death & Disease 4:10, pages e841-e841.
Crossref
Crossref