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Review Article

Predicting success: Optimizing phase II ALS trials for the transition to phase III

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Pages 1-8 | Received 26 Jun 2013, Accepted 26 Aug 2013, Published online: 03 Mar 2014

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H Blasco, F Patin, CR Andres, P Corcia & PH Gordon. (2016) Amyotrophic Lateral Sclerosis, 2016: existing therapies and the ongoing search for neuroprotection. Expert Opinion on Pharmacotherapy 17:12, pages 1669-1682.
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Leonard H. van den BergEric SorensonGary GronsethEric A. MacklinJinsy AndrewsRobert H. BalohMichael BenatarJames D. BerryAdriano Chio, Philippe CorciaAngela GengeAmelie K. GubitzCatherine Lomen-HoerthChristopher J. McDermottErik P. PioroJeffrey Rosenfeld, Vincenzo SilaniMartin R. TurnerMarkus WeberBenjamin Rix BrooksRobert G. MillerHiroshi Mitsumoto. (2019) Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials. Neurology 92:14.
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Ted M. Dawson, Todd E. Golde & Clotilde Lagier-Tourenne. (2018) Animal models of neurodegenerative diseases. Nature Neuroscience 21:10, pages 1370-1379.
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Patricia L. Andres, Margaret (Peggy) Allred, Helen E. Stephens, Mary Proffitt Bunnell, Catherine Siener, Eric A. Macklin, Travis Haines, Robert A. English, Katherine A. Fetterman, Edward J. Kasarskis, Julaine Florence, Zachary Simmons & Merit E. Cudkowicz. (2017) Fixed dynamometry is more sensitive than vital capacity or ALS rating scale. Muscle & Nerve 56:4, pages 710-715.
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Michael J. Grayling & Adrian P. Mander. (2016) Do single-arm trials have a role in drug development plans incorporating randomised trials?. Pharmaceutical Statistics 15:2, pages 143-151.
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Valentin K. Gribkoff. 2015. The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria. The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria 295 321 .
Katharine A. Nicholson, Merit E. Cudkowicz & James D. Berry. (2015) Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?. Neurotherapeutics 12:2, pages 376-383.
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