499
Views
50
CrossRef citations to date
0
Altmetric
Research Article

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

, , , , , , , , , , , , , , , , , , , , , , , , , , & show all
Pages 98-105 | Received 29 May 2013, Accepted 30 Sep 2013, Published online: 13 Nov 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Susan Kathryn Baxter, Maxine Johnson, Mark Clowes, David O’Brien, Paul Norman, Theocharis Stavroulakis, Stephen Bianchi, Mark Elliott, Christopher McDermott & Esther Hobson. (2019) Optimizing the noninvasive ventilation pathway for patients with amyotrophic lateral sclerosis/motor neuron disease: a systematic review. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:7-8, pages 461-472.
Read now
Fabio Coppedè, Andrea Stoccoro, Lorena Mosca, Roberta Gallo, Claudia Tarlarini, Christian Lunetta, Alessandro Marocchi, Lucia Migliore & Silvana Penco. (2018) Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 19:1-2, pages 93-101.
Read now
L. Tremolizzo, E. Conti, M. Bomba, O. Uccellini, M.S. Rossi, M. Marfone, F. Corbetta, M.E. Santarone, M.E. Raggi, F. Neri, C. Ferrarese & R. Nacinovich. (2014) Decreased whole-blood global DNA methylation is related to serum hormones in anorexia nervosa adolescents. The World Journal of Biological Psychiatry 15:4, pages 327-333.
Read now

Articles from other publishers (47)

Fabio Coppedè. 2024. Epigenetics in Human Disease. Epigenetics in Human Disease 333 365 .
Mafalda Rizzuti, Luca Sali, Valentina Melzi, Simone Scarcella, Gianluca Costamagna, Linda Ottoboni, Lorenzo Quetti, Lorenzo Brambilla, Dimitra Papadimitriou, Federico Verde, Antonia Ratti, Nicola Ticozzi, Giacomo Pietro Comi, Stefania Corti & Delia Gagliardi. (2023) Genomic and transcriptomic advances in amyotrophic lateral sclerosis. Ageing Research Reviews 92, pages 102126.
Crossref
Nan Hu & Xubiao Wang. (2022) The level of homocysteine in amyotrophic lateral sclerosis: a systematic review and meta-analysis. Neurological Sciences 44:4, pages 1185-1192.
Crossref
ADRIANA HELENA DE OLIVEIRA REIS, LUNA B. FIGALO, MARCO ORSINI & BERNARDO LEMOS. (2023) The implications of DNA methylation for amyotrophic lateral sclerosis. Anais da Academia Brasileira de Ciências 95:suppl 2.
Crossref
Shalini Swaroop & Yogita K. Adlakha. 2023. Transcription and Translation in Health and Disease. Transcription and Translation in Health and Disease 173 207 .
Zhengyi Cai, Kaili Yin, Qing Liu, Mingsheng Liu, Xunzhe Yang & Liying Cui. (2022) Association between abnormal expression and methylation of LGALS1 in amyotrophic lateral sclerosis. Brain Research 1792, pages 148022.
Crossref
Leanne Jiang & Shyuan T. Ngo. (2022) Altered TDP-43 Structure and Function: Key Insights into Aberrant RNA, Mitochondrial, and Cellular and Systemic Metabolism in Amyotrophic Lateral Sclerosis. Metabolites 12:8, pages 709.
Crossref
Michelle A. Johnson, Jacob A. Klickstein, Richa Khanna, Yunzi Gou & Malavika Raman. (2022) The Cure VCP Scientific Conference 2021: Molecular and clinical insights into neurodegeneration and myopathy linked to multisystem proteinopathy-1 (MSP-1). Neurobiology of Disease 169, pages 105722.
Crossref
Zhengyi Cai, Xinmiao Jia, Mingsheng Liu, Xunzhe Yang & Liying Cui. (2022) Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis. Chinese Medical Journal 135:12, pages 1466-1473.
Crossref
Yulin Jin, Emily G Allen & Peng Jin. (2022) Cell-free DNA methylation as a potential biomarker in brain disorders. Epigenomics 14:7, pages 369-374.
Crossref
Miriam Pacetti, Laura De Conti, Luciano E. Marasco, Maurizio Romano, Mohammad M. Rashid, Martina Nubiè, Francisco E. Baralle & Marco Baralle. (2022) Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications. Disease Models & Mechanisms 15:4.
Crossref
Xiaoxiao Zhang, Jiaming Zhang, Yuchuan Wang, Minji Wang, Man Tang, Yuhan Lin & Qiuyun Liu. (2022) Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective. ACS Chemical Neuroscience 13:2, pages 177-184.
Crossref
Brittany A. Leader, Bala S.C. Koritala, Charles A. Moore, Elaine H. Grigg Dean, Leah C. Kottyan & David F. Smith. (2021) Epigenetics of obstructive sleep apnea syndrome: a systematic review. Journal of Clinical Sleep Medicine 17:12, pages 2533-2541.
Crossref
T. Hartung, M. Rhein, N. Kalmbach, N. Thau-Habermann, M. Naujock, L. Müschen, H. Frieling, J. Sterneckert, A. Hermann, F. Wegner & S. Petri. (2021) Methylation and Expression of Mutant FUS in Motor Neurons Differentiated From Induced Pluripotent Stem Cells From ALS Patients. Frontiers in Cell and Developmental Biology 9.
Crossref
Fabio Coppedè. (2021) One-carbon epigenetics and redox biology of neurodegeneration. Free Radical Biology and Medicine 170, pages 19-33.
Crossref
Tunch Ozyurt & Mukesh Gautam. (2021) Differential Epigenetic Signature of Corticospinal Motor Neurons in ALS. Brain Sciences 11:6, pages 754.
Crossref
Philippe-Pierre Robichaud, Michael Arseneault, Colleen O’Connell, Rodney J. Ouellette & Pier Jr Morin. (2021) Circulating cell-free DNA as potential diagnostic tools for amyotrophic lateral sclerosis. Neuroscience Letters 750, pages 135813.
Crossref
Fabio Coppedè. (2020) Epigenetics of neuromuscular disorders. Epigenomics 12:23, pages 2125-2139.
Crossref
Andrea Stoccoro, Adam R. Smith, Lorena Mosca, Alessandro Marocchi, Francesca Gerardi, Christian Lunetta, Cristina Cereda, Stella Gagliardi, Katie Lunnon, Lucia Migliore & Fabio Coppedè. (2020) Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis. Clinical Epigenetics 12:1.
Crossref
Sophia D Amenyah, Catherine F Hughes, Mary Ward, Samuel Rosborough, Jennifer Deane, Sara-Jayne Thursby, Colum P Walsh, Dieuwertje E Kok, J J Strain, Helene McNulty & Diane J Lees-Murdock. (2020) Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults—a systematic review and meta-analysis. Nutrition Reviews 78:8, pages 647-666.
Crossref
Michele Longoni Calió, Elisandra Henriques, Amanda Siena, Clélia Rejane Antonio Bertoncini, Joana Gil-Mohapel & Tatiana Rosado Rosenstock. (2020) Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment. Frontiers in Neuroscience 14.
Crossref
Ingrid S. Tarr, Emily P. McCann, Beben Benyamin, Timothy J. Peters, Natalie A. Twine, Katharine Y. Zhang, Qiongyi Zhao, Zong-Hong Zhang, Dominic B. Rowe, Garth A. Nicholson, Denis Bauer, Susan J. Clark, Ian P. Blair & Kelly L. Williams. (2019) Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression. Scientific Reports 9:1.
Crossref
Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins & Pamela J. Shaw. (2019) Biomarkers in Motor Neuron Disease: A State of the Art Review. Frontiers in Neurology 10.
Crossref
Giulia Stazi, Clemens Zwergel, Sergio Valente & Antonello Mai. 2019. Epigenetics and Regeneration. Epigenetics and Regeneration 405 444 .
Emily C. Bruggeman & Bing Yao. 2019. The DNA, RNA, and Histone Methylomes. The DNA, RNA, and Histone Methylomes 103 140 .
Andrea Stoccoro, Lorena Mosca, Vittoria Carnicelli, Ugo Cavallari, Christian Lunetta, Alessandro Marocchi, Lucia Migliore & Fabio Coppedè. (2018) Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations. Epigenomics 10:11, pages 1431-1443.
Crossref
Alessandra Masala, Simona Sanna, Sonia Esposito, Mauro Rassu, Manuela Galioto, Angelo Zinellu, Ciriaco Carru, Maria Teresa Carrì, Ciro Iaccarino & Claudia Crosio. (2018) Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes. Neuroscience 390, pages 1-11.
Crossref
Ana Dolinar, Metka Ravnik-Glavač & Damjan Glavač. (2018) Epigenetic mechanisms in amyotrophic lateral sclerosis: A short review. Mechanisms of Ageing and Development 174, pages 103-110.
Crossref
Maja Zadel, Aleš Maver, Anja Kovanda & Borut Peterlin. (2018) DNA Methylation Profiles in Whole Blood of Huntington's Disease Patients. Frontiers in Neurology 9.
Crossref
Nitika Garg, Rupa Joshi & Bikash Medhi. (2018) Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour. Reviews in the Neurosciences 29:4, pages 425-442.
Crossref
Hamid Hamzeiy, Doruk Savaş, Ceren Tunca, Nesli Ece Şen, Aslı Gündoğdu Eken, Irmak Şahbaz, Daniela Calini, Cinzia Tiloca, Nicola Ticozzi, Antonia Ratti, Vincenzo Silani & A. Nazlı Başak. (2018) Elevated Global DNA Methylation Is Not Exclusive to Amyotrophic Lateral Sclerosis and Is Also Observed in Spinocerebellar Ataxia Types 1 and 2. Neurodegenerative Diseases 18:1, pages 38-48.
Crossref
Fabio Coppedè. 2018. Epigenetics in Human Disease. Epigenetics in Human Disease 305 326 .
Mark T. W. Ebbert, Rebecca J. Lank & Veronique V. Belzil. 2018. RNA Metabolism in Neurodegenerative Diseases. RNA Metabolism in Neurodegenerative Diseases 1 29 .
Janou A. Y. Roubroeks, Rebecca G. Smith, Daniel L. A. van den Hove & Katie Lunnon. (2017) Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases. Journal of Neurochemistry 143:2, pages 158-170.
Crossref
E.P. McCann, K.L. Williams, J.A. Fifita, I.S. Tarr, J. O'Connor, D.B. Rowe, G.A. Nicholson & I.P. Blair. (2017) The genotype-phenotype landscape of familial amyotrophic lateral sclerosis in Australia. Clinical Genetics 92:3, pages 259-266.
Crossref
Paul E. Young, Stephen Kum Jew, Michael E. Buckland, Roger Pamphlett & Catherine M. Suter. (2017) Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis. PLOS ONE 12:8, pages e0182638.
Crossref
Melania Filareti, Silvia Luotti, Laura Pasetto, Mauro Pignataro, Katia Paolella, Paolo Messina, Elisabetta Pupillo, Massimiliano Filosto, Christian Lunetta, Jessica Mandrioli, Giuseppe Fuda, Andrea Calvo, Adriano Chiò, Massimo Corbo, Caterina Bendotti, Ettore Beghi & Valentina Bonetto. (2017) Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis. Frontiers in Molecular Neuroscience 10.
Crossref
Alba Jimenez-Pacheco, Jaime M. Franco, Soledad Lopez, Juan Miguel Gomez-Zumaquero, Maria Magdalena Leal-Lasarte, Diana E. Caballero-Hernandez, Marta Cejudo-Guillén & David Pozo. 2017. Neuroepigenomics in Aging and Disease. Neuroepigenomics in Aging and Disease 255 275 .
Veronique V. Belzil, Rebecca B. Katzman & Leonard Petrucelli. (2016) ALS and FTD: an epigenetic perspective. Acta Neuropathologica 132:4, pages 487-502.
Crossref
Mónica Zufiría, Francisco Javier Gil-Bea, Roberto Fernández-Torrón, Juan José Poza, Jose Luis Muñoz-Blanco, Ricard Rojas-García, Javier Riancho & Adolfo López de Munain. (2016) ALS: A bucket of genes, environment, metabolism and unknown ingredients. Progress in Neurobiology 142, pages 104-129.
Crossref
Youn Seo Oh, Seung Hyun Kim & Goang-Won Cho. (2015) Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase. Cellular and Molecular Neurobiology 36:4, pages 613-620.
Crossref
Detlev Boison. (2016) The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine. Frontiers in Molecular Neuroscience 9.
Crossref
Claudia Figueroa-Romero, Junguk Hur, J. Simon Lunn, Ximena Paez-Colasante, Diane E. Bender, Raymond Yung, Stacey A. Sakowski & Eva L. Feldman. (2016) Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. Molecular and Cellular Neuroscience 71, pages 34-45.
Crossref
Pamela Milani & Ernest Fraenkel. 2016. Epigenetic Biomarkers and Diagnostics. Epigenetic Biomarkers and Diagnostics 519 537 .
Detlev Boison & Eleonora Aronica. (2015) Comorbidities in Neurology: Is adenosine the common link?. Neuropharmacology 97, pages 18-34.
Crossref
Ximena Paez-Colasante, Claudia Figueroa-Romero, Stacey A. Sakowski, Stephen A. Goutman & Eva L. Feldman. (2015) Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era. Nature Reviews Neurology 11:5, pages 266-279.
Crossref
Lucio Tremolizzo, Gessica Sala, Elisa Conti, Virginia Rodriguez-Menendez, Antonella Fogli, Angela Michelucci, Paolo Simi, Silvana Penco, Christian Lunetta, Massimo Corbo & Carlo Ferrarese. (2014) Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion. Case Reports in Neurological Medicine 2014, pages 1-7.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.