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Modern Rheumatology Volume 19, 2009 - Issue 5
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ORIGINAL ARTICLE

Imatinib mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference with the Akt signaling pathway

Fumitaka TerabeDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Masayasu KitanoDivision of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
,
Mari KawaiDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Yusuke KuwaharaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Toru HiranoDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Junsuke ArimitsuDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Keisuke HagiharaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Yoshihito ShimaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Masashi NarazakiDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Toshio TanakaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Ichiro KawaseDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
,
Hajime SanoDivision of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
&
Atsushi OgataDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanCorrespondence[email protected]
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Pages 522-529 | Received 25 Sep 2008, Accepted 18 May 2009, Published online: 02 Jan 2014

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Kazuhiro Furuya, Ying Kaku, Ken Yoshida, Kensuke Joh & Daitaro Kurosaka. (2014) Therapeutic effects of sunitinib, one of the anti-angiogenetic drugs, in a murine arthritis. Modern Rheumatology 24:3, pages 487-491.
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Nicole J. Horwood, Ania M. Urbaniak & Lynett Danks. (2012) Tec Family Kinases in Inflammation and Disease. International Reviews of Immunology 31:2, pages 87-103.
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Naotsugu Akashi, Isao Matsumoto, Yoko Tanaka, Asuka Inoue, Kayo Yamamoto, Naoto Umeda, Yuki Tanaka, Taichi Hayashi, Daisuke Goto, Satoshi Ito, Kaneo Sekiguchi & Takayuki Sumida. (2011) Comparative suppressive effects of tyrosine kinase inhibitors imatinib and nilotinib in models of autoimmune arthritis. Modern Rheumatology 21:3, pages 267-275.
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Articles from other publishers (7)

Vidisha Singh, Aurelien Naldi, Sylvain Soliman & Anna Niarakis. (2023) A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint. npj Systems Biology and Applications 9:1.
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Freja Aksel Jacobsen, Alexander N. Scherer, Jeppe Mouritsen, Hera Bragadóttir, B. Thomas Bäckström, Samra Sardar, Dan Holmberg, Anthony J. Koleske & Åsa Andersson. (2018) A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation. Journal of Neuroimmune Pharmacology 13:2, pages 265-276.
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Tatiana V. Beketova, Mikhail Y. Volkov, Evgeniy A. Naryshkin, Tatiana M. Novoselova & Evgeniy L. Nasonov. (2018) Imatinib mesylate use in refractory eosinophilic granulomatosis with polyangiitis: a literature review and a case report. Clinical Rheumatology 37:6, pages 1729-1735.
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Rachel K. Rosenstein, Richard S. Panush, Neil Kramer & Elliot D. Rosenstein. (2014) Hypereosinophilia and Seroconversion of Rheumatoid Arthritis. Clinical Rheumatology 33:11, pages 1685-1688.
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Andrew Filer. (2013) The fibroblast as a therapeutic target in rheumatoid arthritis. Current Opinion in Pharmacology 13:3, pages 413-419.
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Jing Jin GuCatherine P. LavauElena PugachevaErik J. SoderblomM. Arthur MoseleyAnn Marie Pendergast. (2012) Abl Family Kinases Modulate T Cell–Mediated Inflammation and Chemokine-Induced Migration Through the Adaptor HEF1 and the GTPase Rap1. Science Signaling 5:233.
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Masato Shiba, Hidenori Suzuki, Masashi Fujimoto, Naoshi Shimojo, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Kenji Kanamaru, Satoshi Matsushima & Waro Taki. (2012) Imatinib mesylate prevents cerebral vasospasm after subarachnoid hemorrhage via inhibiting tenascin-C expression in rats. Neurobiology of Disease 46:1, pages 172-179.
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