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REVIEW ARTICLE

Rheumatoid arthritis is linked to oral bacteria: etiological association

Pages 453-456 | Received 23 Jan 2009, Accepted 28 May 2009, Published online: 02 Jan 2014

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Mesut Ogrendik. (2013) Rheumatoid arthritis is an autoimmune disease caused by periodontal pathogens. International Journal of General Medicine 6, pages 383-386.
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Seyed Ali Mosaddad, Pegah Mahootchi, Sajedeh Safari, Hussein Rahimi & Seyedeh Sara Aghili. (2023) Interactions between systemic diseases and oral microbiota shifts in the aging community: A narrative review. Journal of Basic Microbiology 63:8, pages 831-854.
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Shima Salehi, Seyedeh Mahsa Mahmoudinezhad Dezfouli, Hossein Azadeh & Shaqayeq Khosravi. (2023) Immune dysregulation and pathogenic pathways mediated by common infections in rheumatoid arthritis. Folia Microbiologica 68:3, pages 325-335.
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Parisa ahmadi, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh mollazadeh, Hadi Sajid Abdulabbas & Seyed-Alireza Esmaeili. (2023) Impacts of Porphyromonas gingivalis periodontitis on rheumatoid arthritis autoimmunity. International Immunopharmacology 118, pages 109936.
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Shima Afrasiabi, Nasim Chiniforush, Alireza Partoazar & Ramin Goudarzi. (2023) The role of bacterial infections in rheumatoid arthritis development and novel therapeutic interventions: Focus on oral infections. Journal of Clinical Laboratory Analysis 37:8.
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Elena Niccolai, Silvia Bellando Randone & Amedeo Amedei. 2023. Translational Autoimmunity. Translational Autoimmunity 83 111 .
Cinzia Casu, Martina Salvatorina Murgia, Germano Orrù & Alessandra Scano. (2022) Photodynamic therapy for the successful management of cyclosporine-related gum hypertrophy: A novel therapeutic option. Journal of Public Health Research 11:4, pages 227990362211161.
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Anders Esberg, Linda Johansson, Ewa Berglin, Aladdin J. Mohammad, Andreas P. Jonsson, Johanna Dahlqvist, Bernd Stegmayr, Ingegerd Johansson & Solbritt Rantapää-Dahlqvist. (2022) Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis. Microorganisms 10:8, pages 1572.
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Joanna Koziel & Jan Potempa. (2022) Pros and cons of causative association between periodontitis and rheumatoid arthritis. Periodontology 2000 89:1, pages 83-98.
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. 2022. Clinical Cases in Periodontics. Clinical Cases in Periodontics 57 72 .
Sung Cheng Looh, Zoey May Pheng Soo, Jia Jia Wong, Hok Chai Yam, Sook Khuan Chow & Jung Shan Hwang. (2022) Aggregatibacter actinomycetemcomitans as the Aetiological Cause of Rheumatoid Arthritis: What Are the Unsolved Puzzles?. Toxins 14:1, pages 50.
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Jiajia Dong, Wei Li, Qi Wang, Jiahao Chen, Yue Zu, Xuedong Zhou & Qiang Guo. (2022) Relationships Between Oral Microecosystem and Respiratory Diseases. Frontiers in Molecular Biosciences 8.
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Anders Esberg, Linda Johansson, Ingegerd Johansson & Solbritt Rantapää Dahlqvist. (2021) Oral Microbiota Identifies Patients in Early Onset Rheumatoid Arthritis. Microorganisms 9:8, pages 1657.
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Yiqiang Qiao, Zao Wang, Yafang Li, Yafei Han, Yanheng Zhou & Xuanping Cao. (2021) Risque de polyarthrite rhumatoïde chez les patients atteints de parodontite : revue systématique et méta-analyse. Revue du Rhumatisme 88:1, pages 15-23.
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Yiqiang Qiao, Zao Wang, Yafang Li, Yafei Han, Yanheng Zhou & Xuanping Cao. (2020) Rheumatoid arthritis risk in periodontitis patients: A systematic review and meta-analysis. Joint Bone Spine 87:6, pages 556-564.
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Viviana Pitones-Rubio, E.G. Chávez-Cortez, Angélica Hurtado-Camarena, Anna González-Rascón & Nicolás Serafín-Higuera. (2020) Is periodontal disease a risk factor for severe COVID-19 illness?. Medical Hypotheses 144, pages 109969.
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Petra Surlin, Liliana Foia, Sorina Solomon, Dora Maria Popescu, Dorin Nicolae Gheorghe, Adrian Camen, Maria Alexandra Martu, Anne Marie Rauten, Madalina Olteanu, Allma Pitru, Vasilica Toma, Simona Popa, Mihail Virgil Boldeanu, Silvia Martu & Ion Rogoveanu. 2020. Cytokines. Cytokines.
Nazurah Nik Eezammuddeen, Rathna Devi Vaithilingam, Norul Husna Mohamad Hassan & Peter Mark Bartold. (2020) Association Between Rheumatoid Arthritis and Periodontitis: Recent Progress. Current Oral Health Reports 7:2, pages 139-153.
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Dargham Bayan Mohsen Hammad, Veranja Liyanapathirana & Daniel Paul Tonge. (2019) Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects. PLOS ONE 14:11, pages e0225110.
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Lorenzo Drago, Gian Vincenzo Zuccotti, Carlo Luca Romanò, Karan Goswami, Jorge Hugo Villafañe, Roberto Mattina & Javad Parvizi. (2019) Oral–Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?. Journal of Clinical Medicine 8:10, pages 1753.
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Alberta Lucchese. (2019) Periodontal bacteria and the rheumatoid arthritis-related antigen RA-A47: the cross-reactivity potential. Current Opinion in Rheumatology 31:5, pages 542-545.
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Joanne E. Konkel, Conor O'Boyle & Siddharth Krishnan. (2019) Distal Consequences of Oral Inflammation. Frontiers in Immunology 10.
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Weiyi Pan, Wuwei Yin, Li Yang, Lili Xue, Jie Ren, Wei Wei, Qiuyu Lu, Handong Ding, Zhaohui Liu, Neel R. Nabar, Min Wang & Liang Hao. (2019) Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway. Journal of Clinical Periodontology 46:3, pages 286-296.
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Paul Arana, Diana Salazar, Sandra Amaya, Michelle Medina, Sandra Moreno-Correa, Freddy Moreno, Herman González & Adolfo Contreras. (2018) Periodontal microorganisms in synovial fluid of patients with rheumatoid arthritis. Systematic review of the literature – 2017. Revista Colombiana de Reumatología (English Edition) 25:4, pages 271-286.
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Paul Arana, Diana Salazar, Sandra Amaya, Michelle Medina, Sandra Moreno-Correa, Freddy Moreno, Herman González & Adolfo Contreras. (2018) Microorganismos periodontales en el líquido sinovial de pacientes con artritis reumatoide. Revisión sistemática de la literatura 2017. Revista Colombiana de Reumatología 25:4, pages 271-286.
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Yan Zhao, Bin Chen, Shufeng Li, Lanxiu Yang, Dequan Zhu, Ye Wang, Haiying Wang, Tao Wang, Bin Shi, Zhongtao Gai, Jun Yang, Xueyuan Heng, Junjie Yang & Lei Zhang. (2018) Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients. Scientific Reports 8:1.
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G. Jia, A. Zhi, P. F. H. Lai, G. Wang, Y. Xia, Z. Xiong, H. Zhang, N. Che & L. Ai. (2018) The oral microbiota – a mechanistic role for systemic diseases. British Dental Journal 224:6, pages 447-455.
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J. Oldeweme, J. Detert, H. Dommisch & N. Pischon. (2016) Zusammenh?nge zwischen Parodontitis und rheumatischen Erkrankungen am Beispiel der rheumatoiden Arthritis. wissen kompakt 10:3, pages 121-128.
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Özlem Yilmaz & Kyu Lim Lee. (2015) The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. Periodontology 2000 69:1, pages 83-95.
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M. Sağlam, S. Köseoğlu, L. Savran, T. Pekbağriyanik, G. Sağlam & R. Sütçü. (2015) Levels of interleukin-37 in gingival crevicular fluid, saliva, or plasma in periodontal disease. Journal of Periodontal Research 50:5, pages 614-621.
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Liang Hao, Guochun Zhu, Yun Lu, Min Wang, Joel Jules, Xuedong Zhou & Wei Chen. (2015) Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role. FEBS Letters 589:12, pages 1331-1339.
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Ester G. Penserga, Therese Aileen L. Natividad & Evelyn S. Salido. (2015) Clinical profile of 266 Filipino patients with rheumatoid arthritis included in the rheumatoid arthritis database and registry (RADAR) of the Philippine General Hospital. International Journal of Rheumatic Diseases 18:4, pages 433-438.
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Mesut Ogrendik. (2014) Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis. Open Journal of Rheumatology and Autoimmune Diseases 04:03, pages 162-169.
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Rupali Agnihotri & Sumit Gaur. (2014) Rheumatoid arthritis in the elderly and its relationship with periodontitis: A review. Geriatrics & Gerontology International 14:1, pages 8-22.
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Alexandra Zhernakova, Sebo Withoff & Cisca Wijmenga. (2013) Clinical implications of shared genetics and pathogenesis in autoimmune diseases. Nature Reviews Endocrinology 9:11, pages 646-659.
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Jeffrey L. Ebersole, Dolphus R. DawsonIIIIII, Lorri A. Morford, Rebecca Peyyala, Craig S. Miller & Octavio A. Gonzaléz. (2013) Periodontal disease immunology: ‘double indemnity’ in protecting the host. Periodontology 2000 62:1, pages 163-202.
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K Erciyas, U Sezer, K Üstün, Y Pehlivan, B Kısacık, SZ Şenyurt, M Tarakçıoğlu & AM Onat. (2012) Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients. Oral Diseases 19:4, pages 394-400.
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Najah Al-Muhtaseb, Elham Al-Kaissi, Abdul Jalil Thawaini, Zuhair Muhi Eldeen, Sabah Al-Muhtaseb & Badiee Al-Saleh. (2011) The role of human xanthine oxidoreductase (HXOR), anti-HXOR antibodies, and microorganisms in synovial fluid of patients with joint inflammation. Rheumatology International 32:8, pages 2355-2362.
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Sushil Kaur, Sarahlouise White & Mark Bartold. (2012) Periodontal Disease as a Risk Factor for Rheumatoid Arthritis: A Systematic Review. JBI Library of Systematic Reviews 10:42, pages 1-12.
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Karin Lundberg, Natalia Wegner, Tülay Yucel-Lindberg & Patrick J. Venables. (2010) Periodontitis in RA—the citrullinated enolase connection. Nature Reviews Rheumatology 6:12, pages 727-730.
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Thais Oliveira Gonçalves, Dirceu Costa, Claudia Ida Brodskyn, Poliana Mendes Duarte, João Batista César Neto & Getulio Nogueira-Filho. (2010) Release of cytokines by stimulated peripheral blood mononuclear cells in chronic periodontitis. Archives of Oral Biology 55:12, pages 975-980.
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Jacqueline Detert, Nicole Pischon, Gerd R Burmester & Frank Buttgereit. (2010) The association between rheumatoid arthritis and periodontal disease. Arthritis Research & Therapy 12:5.
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E. Röhner, J. Detert, P. Kolar, A. Hocke, P. N’Guessan, G. Matziolis, V. Kanitz, J. P. Bernimoulin, A. Kielbassa, G. R. Burmester, F. Buttgereit & N. Pischon. (2010) Induced Apoptosis of Chondrocytes by Porphyromonas gingivalis as a Possible Pathway for Cartilage Loss in Rheumatoid Arthritis. Calcified Tissue International 87:4, pages 333-340.
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