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Case Report

Rituximab was effective on refractory thrombotic thrombocytopenic purpura but induced a flare of hemophagocytic syndrome in a patient with systemic lupus erythematosus

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Pages 81-85 | Received 14 Apr 2009, Accepted 26 Aug 2009, Published online: 02 Jan 2014

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Noriaki Kawano, Naoko Yokota-Ikeda, Sayaka Kawano, Takuro Kuriyama, Kiyoshi Yamashita, Nobuyuki Ono, Naoyasu Ueda, Ochiai Hidenobu, Fumihiko Ishikawa, Ikuo Kikuchi, Kazuya Shimoda & Masanori Matsumoto. (2018) Clinical effect of rituximab as early administration for refractory thrombotic thrombocytopenic purpura associated with connective tissue diseases. Modern Rheumatology Case Reports 2:1, pages 59-67.
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Min Wook So, Bon San Koo, You Jae Kim, Yong-Gil Kim, Chang-Keun Lee & Bin Yoo. (2014) Successful rituximab treatment of refractory hemophagocytic lymphohistiocytosis and autoimmune hemolytic anemia associated with systemic lupus erythematosus. Modern Rheumatology 24:5, pages 855-857.
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Anna Lis-Święty, Ligia Brzezińska-Wcisło, Małgorzata Widuchowska & Eugeniusz Kucharz. (2013) Subacute cutaneous lupus erythematosus in the course of rheumatoid arthritis: a relationship with TNF-α antagonists and rituximab therapy?. Immunopharmacology and Immunotoxicology 35:3, pages 443-446.
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Articles from other publishers (12)

Georgia Griffin, Susan Shenoi & Grant C. Hughes. (2020) Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy. Best Practice & Research Clinical Rheumatology 34:4, pages 101515.
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Ji Li, Jing-Jing Jiang, Chang-Yan Wang, Shan Jian, Yu Zhou, Ming-Sheng Ma, Xiao-Yan Tang, Lin Wang, Mei-Ying Quan, Yu Zhang, Juan Xiao, Yan-Yan He & Hong-Mei Song. (2019) Clinical features and prognosis of patients with thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a review of 25 cases. Italian Journal of Pediatrics 45:1.
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Kumpol Aiempanakit & Benjawan Apinantriyo. (2018) Thrombotic thrombocytopenic purpura and hemophagocytic lymphohistiocytosis in an elderly man. Medicine 97:44, pages e13025.
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Ai-Chun Liu, Yue Yang, Meng-Tao Li, Yuan Jia, Sheng Chen, Shuang Ye, Xiang-Zong Zeng, Zhao Wang, Jin-Xia Zhao, Xiang-Yuan Liu, Jian Zhu, Yan Zhao, Xiao-Feng Zeng & Zhan-Guo Li. (2017) Macrophage activation syndrome in systemic lupus erythematosus: a multicenter, case-control study in China. Clinical Rheumatology 37:1, pages 93-100.
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Pierre-Edouard Gavand, Ilaria Serio, Laurent Arnaud, Nathalie Costedoat-Chalumeau, Julien Carvelli, Antoine Dossier, Olivier Hinschberger, Luc Mouthon, Véronique Le Guern, Anne-Sophie Korganow, Vincent Poindron, Clément Gourguechon, Christian Lavigne, François Maurier, Guylaine Labro, Marie Heymonet, Matthieu Artifoni, Amélie Brabant Viau, Cristophe Deligny, Thomas Sene, Louis Terriou, Jean Sibilia, Alexis Mathian, Coralie Bloch-Queyrat, Claire Larroche, Zahir Amoura & Thierry Martin. (2017) Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: A study of 103 episodes in 89 adult patients. Autoimmunity Reviews 16:7, pages 743-749.
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Pilar Brito-Zerón, Xavier Bosch, Marta Pérez-de-Lis, Roberto Pérez-Álvarez, Guadalupe Fraile, Hoda Gheitasi, Soledad Retamozo, Albert Bové, Ester Monclús, Ona Escoda, Asunción Moreno, Armando López-Guillermo, Munther A. Khamashta & Manuel Ramos-Casals. (2016) Infection is the major trigger of hemophagocytic syndrome in adult patients treated with biological therapies. Seminars in Arthritis and Rheumatism 45:4, pages 391-399.
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Nicolás Coronel Restrepo, Carolina Muñoz-Grajales, Carlos Jaime Velásquez, Javier Márquez & Luis Fernando Pinto. (2015) Anemia hemolítica microangiopática en lupus eritematoso sistémico: revisión narrativa de la literatura. Revista Colombiana de Reumatología 22:3, pages 162-167.
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H Takahashi, H Tsuboi, I Kurata, H Takahashi, S Inoue, H Ebe, M Yokosawa, S Hagiwara, T Hirota, H Asashima, S Kaneko, H Kawaguchi, Y Kurashima, H Miki, N Umeda, Y Kondo, H Ogishima, T Suzuki, I Matsumoto & T Sumida. (2014) Predictors of the response to treatment in acute lupus hemophagocytic syndrome. Lupus 24:7, pages 659-668.
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A. Yu. Zakharova, Z. Yu. Mutovina, A. V. Gordeev & I. N. Shestakova. (2015) Hemophagocytic syndrome in patients with adult-onset Still’s disease: Diagnostic problems. Terapevticheskii arkhiv 87:5, pages 84.
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Honghao Jiang, Xiangjie An, Ya Li, Yi Sun, Guanxin Shen, Yating Tu & Juan Tao. (2013) Clinical features and prognostic factors of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a literature review of 105 cases from 1999 to 2011. Clinical Rheumatology 33:3, pages 419-427.
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Yo Ueda, Hiroyuki Yamashita, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano & Akio Mimori. (2013) Refractory hemophagocytic syndrome in systemic lupus erythematosus successfully treated with intermittent intravenous cyclophosphamide: three case reports and literature review. Clinical Rheumatology 33:2, pages 281-286.
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M AringerH BurkhardtGR BurmesterR Fischer-BetzM FleckW GraningerF HiepeAM JacobiI KötterHJ LakomekHM LorenzB MangerG SchettRE SchmidtM SchneiderH Schulze-KoopsJS SmolenC SpeckerT StollA StrangfeldHP TonyPM VilligerR VollT WitteT Dörner. (2011) Current state of evidence on ‘off-label’ therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria and Switzerland – a consensus report. Lupus 21:4, pages 386-401.
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