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Original Article

Marked increase in serum KL-6 and surfactant protein D levels during the first 4 weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis

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Pages 872-883 | Received 24 May 2012, Accepted 21 Aug 2012, Published online: 02 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Takahisa Gono & Masataka Kuwana. (2023) New paradigm in the treatment of myositis-associated interstitial lung disease. Expert Review of Respiratory Medicine 17:5, pages 397-411.
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Masanori Hanaoka, Yasuhiro Katsumata, Hidenaga Kawasumi, Yasushi Kawaguchi & Hisashi Yamanaka. (2019) KL-6 is a long-term disease-activity biomarker for interstitial lung disease associated with polymyositis/dermatomyositis, but is not a short-term disease-activity biomarker. Modern Rheumatology 29:4, pages 625-632.
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Hitoshi Kohsaka, Tsuneyo Mimori, Takashi Kanda, Jun Shimizu, Yoshihide Sunada, Manabu Fujimoto, Yasushi Kawaguchi, Masatoshi Jinnin, Yoshinao Muro, Shoichiro Ishihara, Hiroyuki Tomimitsu, Akiko Ohta & Takayuki Sumida. (2019) Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists. Modern Rheumatology 29:1, pages 1-19.
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Youhei Fujiki, Takuya Kotani, Kentaro Isoda, Takaaki Ishida, Takeshi Shoda, Shuzo Yoshida, Tohru Takeuchi & Shigeki Makino. (2018) Evaluation of clinical prognostic factors for interstitial pneumonia in anti-MDA5 antibody-positive dermatomyositis patients. Modern Rheumatology 28:1, pages 133-140.
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Yuting Zhu, Jianhua Fu, Kai You, Linlin Jin, Min Wang, Danchi Lu & Xindong Xue. (2013) Changes in pulmonary tissue structure and KL-6/MUC1 expression in a newborn rat model of hyperoxia-Induced bronchopulmonary dysplasia. Experimental Lung Research 39:10, pages 417-426.
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Masaru Ejima, Tsukasa Okamoto, Takafumi Suzuki & Yasunari Miyazaki. (2022) Role of serum surfactant protein-D as a prognostic predictor in fibrotic hypersensitivity pneumonitis. Respiratory Investigation 60:3, pages 369-378.
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Shinjiro Kaieda, Takahisa Gono, Kenichi Masui, Naoshi Nishina, Shinji Sato & Masataka Kuwana. (2020) Evaluation of usefulness in surfactant protein D as a predictor of mortality in myositis-associated interstitial lung disease. PLOS ONE 15:6, pages e0234523.
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M. Kristen Demoruelle, Shikha Mittoo & Joshua J. Solomon. (2016) Connective tissue disease-related interstitial lung disease. Best Practice & Research Clinical Rheumatology 30:1, pages 39-52.
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Norimoto Kobayashi, Ichiro Kobayashi, Masaaki Mori, Shinji Sato, Naomi Iwata, Tomonari Shigemura, Kazunaga Agematsu, Shumpei Yokota & Kenichi Koike. (2015) Increased Serum B Cell Activating Factor and a Proliferation-inducing Ligand Are Associated with Interstitial Lung Disease in Patients with Juvenile Dermatomyositis. The Journal of Rheumatology 42:12, pages 2412-2418.
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Deborah Assayag & Christopher J. Ryerson. (2015) Determining Respiratory Impairment in Connective Tissue Disease?Associated Interstitial Lung Disease. Rheumatic Disease Clinics of North America 41:2, pages 213-223.
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Kentaro Isoda, Tohru Takeuchi, Takuya Kotani, Kenichiro Hata, Takeshi Shoda, Takaaki Ishida, Shuzo Yoshida, Yuko Kimura, Shigeki Makino & Toshiaki Hanafusa. (2014) Pre-Treatment Ferritin Level and Alveolar-Arterial Oxygen Gradient Can Predict Mortality Rate Due to Acute/Subacute Interstitial Pneumonia in Dermatomyositis Treated by Cyclosporine A/Glucocorticosteroid Combination Therapy: A Case Control Study. PLoS ONE 9:2, pages e89610.
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