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Original Article

Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis

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Pages 1001-1007 | Received 31 Jul 2012, Accepted 18 Oct 2012, Published online: 02 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Neda Ghamarzad Shishavan, Bahram Pourghassem Gargari, Sousan Kolahi, Mehrzad Hajialilo, Mohammad Asghari Jafarabadi & Yousef Javadzadeh. (2016) Effects of Vitamin K on Matrix Metalloproteinase-3 and Rheumatoid Factor in Women with Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial . Journal of the American College of Nutrition 35:5, pages 392-398.
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Articles from other publishers (32)

Ianthe Piscaer, Rob Janssen, Frits M. E. Franssen, Leon J. Schurgers & Emiel F. M. Wouters. (2023) The Pleiotropic Role of Vitamin K in Multimorbidity of Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine 12:4, pages 1261.
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Ayşe Merve Çıracıoğlu, Onur Armağan, Sema Uslu, Funda Berkan, Merih Özgen, Suheyla Dal Erdoğan & Ertuğrul Çolak. (2023) Vitamin K levels in Fibromyalgia Syndrome Patients and Their Associations with Pain, Disease Activity, Quality of Life and Inflammatory Cytokines. Pain Management Nursing 24:1, pages 60-67.
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Radwa Mekky, Noha Elemam, Omar Eltahtawy, Yousra Zeinelabdeen & Rana Youness. (2022) Evaluating Risk: Benefit Ratio of Fat-Soluble Vitamin Supplementation to SARS-CoV-2-Infected Autoimmune and Cancer Patients: Do Vitamin–Drug Interactions Exist?. Life 12:10, pages 1654.
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Luciana Pereira & Rosário Monteiro. (2022) Tailoring gut microbiota with a combination of Vitamin K and probiotics as a possible adjuvant in the treatment of rheumatic arthritis: a systematic review. Clinical Nutrition ESPEN 51, pages 37-49.
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E. A. Nikitina, S. V. Orlova, Kh. A. Magomedova, N. V. Balashova, E. V. Prokopenko, A. N. Vodolazkaya & O. E. Pronina. (2022) Vitamin K2: known and unknown. Modern view: opportunities and prospects. Medical alphabet:16, pages 102-108.
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Liyan Mei, Zhihua Yang, Xiaolin Zhang, Zehao Liu, Maojie Wang, Xiaodong Wu, Xiumin Chen, Qingchun Huang & Runyue Huang. (2021) Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis. Frontiers in Immunology 12.
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Wencheng Xu, Hongguang Wu, Koichiro Tahara, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kentaro Sugiyama, Tetsuji Sawada & Toshihiko Hirano. (2021) Effects of vitamin K 2 combined with methotrexate against mitogen‐activated peripheral blood mononuclear cells of healthy subjects and rheumatoid arthritis patients . Fundamental & Clinical Pharmacology 35:5, pages 832-842.
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Michael Stock & Georg Schett. (2021) Vitamin K-Dependent Proteins in Skeletal Development and Disease. International Journal of Molecular Sciences 22:17, pages 9328.
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Emmanuel Arkorful, Ying Yu, Changsong Chen, Li Lu, Shunkai Hu, Hanpu Yu, Qingping Ma, Kuberan Thangaraj, Rajiv Periakaruppan, Anburaj Jeyaraj, Xuan Chen & Xinghui Li. (2020) Untargeted metabolomic analysis using UPLC-MS/MS identifies metabolites involved in shoot growth and development in pruned tea plants (Camellia sinensis (L.) O. Kuntz). Scientia Horticulturae 264, pages 109164.
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Dina C. Simes, Carla S. B. Viegas, Nuna Araújo & Catarina Marreiros. (2019) Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. International Journal of Molecular Sciences 20:17, pages 4150.
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Ploingarm PetsophonsakulMalgorzata FurmanikRachael ForsytheMarc DweckGeert Willem Schurink, Ehsan NatourChris ReutelingspergerMichael JacobsBarend MeesLeon Schurgers. (2019) Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation. Arteriosclerosis, Thrombosis, and Vascular Biology 39:7, pages 1351-1368.
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David Langan, Eugene Y. Kim & Kamal D. Moudgil. (2019) Modulation of autoimmune arthritis by environmental ‘hygiene’ and commensal microbiota. Cellular Immunology 339, pages 59-67.
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Amanda Sánchez-Recillas, Laura Rivero-Medina, Rolffy Ortiz-Andrade, Jesus Alfredo Araujo-León & J. Salvador Flores-Guido. (2019) Airway smooth muscle relaxant activity of Cordia dodecandra A. DC. mainly by cAMP increase and calcium channel blockade. Journal of Ethnopharmacology 229, pages 280-287.
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Neda Ghamarzad Shishavan & Bahram Pourghassem Gargari. 2019. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases 161 173 .
Miji Kim, Anam Basharat, Ramchandani Santosh, Syed F. Mehdi, Zanali Razvi, Sun K. Yoo, Barbara Lowell, Amrat Kumar, Wunnie Brima, Ann Danoff, Rachel Dankner, Michael Bergman, Valentin A. Pavlov, Huan Yang & Jesse Roth. (2019) Reuniting overnutrition and undernutrition, macronutrients, and micronutrients. Diabetes/Metabolism Research and Reviews 35:1, pages e3072.
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Junichi Kusano, Sachiko Tanaka, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Shinya Suzuki, Masao Sekiyama, Eiki Ando, Kentaro Sugiyama & Toshihiko Hirano. (2018) Vitamin K1 and Vitamin K2 immunopharmacological effects on the peripheral lymphocytes of healthy subjects and dialysis patients, as estimated by the lymphocyte immunosuppressant sensitivity test. Journal of Clinical Pharmacy and Therapeutics 43:6, pages 895-902.
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Neda Ghamarzad Shishavan, Bahram Pourghassem Gargari, Mohammad Asghari Jafarabadi, Sousan Kolahi, Sepideh Haggifar & Soheila Noroozi. (2018) Vitamin K 1 Supplementation Did Not Alter Inflammatory Markers and Clinical Status in Patients with Rheumatoid Arthritis . International Journal for Vitamin and Nutrition Research 88:5-6, pages 251-257.
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Kosuke Ebina, Makoto Hirao, Jun Hashimoto, Keisuke Hagihara, Masafumi Kashii, Kazuma Kitaguchi, Hozo Matsuoka, Toru Iwahashi, Ryota Chijimatsu & Hideki Yoshikawa. (2017) Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis. Journal of Bone and Mineral Metabolism 36:4, pages 478-487.
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Maytham A. Dragh, Zhiliang Xu, Zainab S. Al-Allak & Ling Hong. (2017) Vitamin K2 Prevents Lymphoma in Drosophila. Scientific Reports 7:1.
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Kosuke Ebina, Masafumi Kashii, Makoto Hirao, Jun Hashimoto, Takaaki Noguchi, Kota Koizumi, Kazuma Kitaguchi, Hozo Matsuoka, Toru Iwahashi, Yasunori Tsukamoto & Hideki Yoshikawa. (2016) Comparison of the effects of denosumab between a native vitamin D combination and an active vitamin D combination in patients with postmenopausal osteoporosis. Journal of Bone and Mineral Metabolism 35:5, pages 571-580.
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Hani M. Khojah, Sameh Ahmed, Mahran S. Abdel-Rahman, Khaled M. Alkhalil & Al-Badr Hamza. (2016) Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis. Journal of Bone and Mineral Metabolism 35:5, pages 529-535.
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Kosuke Ebina, Jun Hashimoto, Masafumi Kashii, Makoto Hirao, Shoichi Kaneshiro, Takaaki Noguchi, Yasunori Tsukamoto & Hideki Yoshikawa. (2016) The effects of switching daily teriparatide to oral bisphosphonates or denosumab in patients with primary osteoporosis. Journal of Bone and Mineral Metabolism 35:1, pages 91-98.
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Eri Shiraishi, Hideki Iijima, Shinichiro Shinzaki, Sachiko Nakajima, Takahiro Inoue, Satoshi Hiyama, Shoichiro Kawai, Manabu Araki, Toshio Yamaguchi, Yoshito Hayashi, Hironobu Fujii, Tsutomu Nishida, Masahiko Tsujii & Tetsuo Takehara. (2015) Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis. Journal of Gastroenterology 51:4, pages 346-356.
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K. Ebina, T. Noguchi, M. Hirao, J. Hashimoto, S. Kaneshiro, M. Yukioka & H. Yoshikawa. (2015) Effects of switching weekly alendronate or risedronate to monthly minodronate in patients with rheumatoid arthritis: a 12-month prospective study. Osteoporosis International 27:1, pages 351-359.
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Sameh Ahmed & Ashraf M. Mahmoud. (2015) A novel salting-out assisted extraction coupled with HPLC- fluorescence detection for trace determination of vitamin K homologues in human plasma. Talanta 144, pages 480-487.
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Takaaki Noguchi, Kosuke Ebina, Makoto Hirao, Ryota Kawase, Tohru Ohama, Shizuya Yamashita, Tokimitsu Morimoto, Kota Koizumi, Kazuma Kitaguchi, Hozo Matsuoka, Shoichi Kaneshiro & Hideki Yoshikawa. (2015) Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice. Biochemical and Biophysical Research Communications 465:3, pages 638-643.
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Mahran S. Abdel-Rahman, Eman A.M. Alkady & Sameh Ahmed. (2015) Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study. European Journal of Pharmacology 761, pages 273-278.
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Charlotte A. Keyzer, Cees Vermeer, Michel M. Joosten, Marjo H.J. Knapen, Nadja E.A. Drummen, Gerjan Navis, Stephan J.L. Bakker & Martin H. de Borst. (2015) Vitamin K Status and Mortality After Kidney Transplantation: A Cohort Study. American Journal of Kidney Diseases 65:3, pages 474-483.
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M. H. J. Knapen, L. A. J. L. M. Braam, N. E. Drummen, O. Bekers, A. P. G. Hoeks & C. Vermeer. (2015) Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. Thrombosis and Haemostasis 113:5, pages 1135-1144.
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Sousan KolahiBahram Pourghassem GargariMehran Mesgari AbbasiMohammad Asghari JafarabadiNeda Ghamarzad Shishavan. (2015) Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis: a double blind placebo controlled study. Nutrition Research and Practice 9:2, pages 186.
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Marjo H. J. Knapen, Lavienja A. J. L. M. Braam, Kirsten J. Teunissen, Renate M. L. Zwijsen, Elke Theuwissen & Cees Vermeer. (2015) Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population. Journal of Nutritional Science 4.
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C. Vermeer. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.

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