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Journal of Medical Economics Volume 12, 2009 - Issue 4

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Original Article

Pediatric gastroesophageal reflux disease and acid-related conditions: trends in incidence of diagnosis and acid suppression therapy

S. P. Nelson The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

S. Kothari Takeda Pharmaceuticals North America, Inc., Deerfield, IL, USA

E. Q. Wu Analysis Group Inc., Boston, MA, USACorrespondence[email protected]

N. Beaulieu Analysis Group Inc., Boston, MA, USA

J. M. McHale Analysis Group Inc., Boston, MA, USA

O. H. Dabbous Takeda Pharmaceuticals North America, Inc., Deerfield, IL, USA

Pages 348-355 | Published online: 15 Oct 2009

Cite this article
https://doi.org/10.3111/13696990903378680

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Rachel Rosen. (2023) Gastroesophageal Reflux Treatment in Infancy Through Young Adulthood. American Journal of Gastroenterology 118:3, pages 452-458.
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Jeyasakthy Saniasiaya & Jeyanthi Kulasegarah. (2023) The link between airway reflux and non-acid reflux in children: a review. Brazilian Journal of Otorhinolaryngology 89:2, pages 329-338.
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Emilie Raaum Closs, Karl Mårild, Rasmus Gaardskær Nielsen & Ketil Størdal. (2023) Use of proton pump inhibitors in scandinavian children and adolescents: An observational study. Frontiers in Pediatrics 11.
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Miriam Lyamouri, Karl Mårild, Rasmus Gaardskær Nielsen & Ketil Størdal. (2022) Proton pump inhibitors for infants in three Scandinavian countries increased from 2007 to 2020 despite international recommendations. Acta Paediatrica 111:11, pages 2222-2228.
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Tomotaka Ugai, Naoko Sasamoto, Hwa-Young Lee, Mariko Ando, Mingyang Song, Rulla M. Tamimi, Ichiro Kawachi, Peter T. Campbell, Edward L. Giovannucci, Elisabete Weiderpass, Timothy R. Rebbeck & Shuji Ogino. (2022) Is early-onset cancer an emerging global epidemic? Current evidence and future implications. Nature Reviews Clinical Oncology 19:10, pages 656-673.
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Tammie Dewan, Justine Turner, Brendan Cord Lethebe & David W Johnson. (2022) Gastro-oesophageal reflux disease in children with neurological impairment: a retrospective cohort study. BMJ Paediatrics Open 6:1, pages e001577.
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Morgan Hines, Nicole Hardy, Alaina Martens & Emily Zimmerman. (2022) Birth order effects on breastfeeding self-efficacy, parent report of problematic feeding and infant feeding abilities. Journal of Neonatal Nursing 28:1, pages 16-20.
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Yvan Vandenplas & Sébastien Kindt. 2022. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition 125 155 .

Ronnie Fass, Guy E. Boeckxstaens, Hashem El-Serag, Rachel Rosen, Daniel Sifrim & Michael F. Vaezi. (2021) Gastro-oesophageal reflux disease. Nature Reviews Disease Primers 7:1.
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Rachel Rosen & Samuel Nurko. 2021. The Esophagus. The Esophagus 581 590 .

Gaston Arnolda, Harriet Hiscock, David Moore, Glen Farrow, Peter D. Hibbert, Louise K. Wiles, Hseun P. Ting, Charlotte J. Molloy, Meagan Warwick & Jeffrey Braithwaite. (2021) Assessing the appropriateness of the management of gastro-oesophageal reflux in Australian children: a population-based sample survey. Scientific Reports 11:1.
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Peymaneh Alizadeh Taheri, Elahe Validad & Kambiz Eftekhari. (2021) The Safety and Efficacy of Lansoprazole plus Metoclopramide among Neonates with Gastroesophageal Reflux Disease Resistant to Conservative Therapy and Monotherapy: A Clinical Trial. International Journal of Pediatrics 2021, pages 1-9.
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Yvan Vandenplas. 2021. Pediatric Gastrointestinal and Liver Disease. Pediatric Gastrointestinal and Liver Disease 212 229.e6 .

Ishani D. Premaratne, Nicholas Brownstone, Philip Lotfi & Thomas A. Imahiyerobo. (2020) Incidence of Gastroesophageal Reflux Disease in Children With Cleft Lip and Palate and an Evaluation of Its Impact on Weight Gain. Annals of Plastic Surgery 85:S1, pages S141-S142.
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Elaine Barfield & Michelle W. Parker. (2019) Management of Pediatric Gastroesophageal Reflux Disease. JAMA Pediatrics 173:5, pages 485.
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Emily Zimmerman & Austin Rosner. (2018) Feeding swallowing difficulties in the first three years of life: A preterm and full-term infant comparison. Journal of Neonatal Nursing 24:6, pages 331-335.
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Nina F. Steutel, Miranda W. Langendam, Marc A. Benninga, Minke E.P. Jansen & Merit M. Tabbers. (2018) A Multifaceted Intervention to Reduce Pediatric Acid-Suppressant Prescriptions for Gastroesophageal Reflux: What Have We Learned?. Journal of Pediatric Gastroenterology & Nutrition 67:5, pages 605-609.
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Eitan Rubinstein & Rachel L. Rosen. (2018) Respiratory symptoms associated with eosinophilic esophagitis. Pediatric Pulmonology 53:11, pages 1587-1591.
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Brendan Ryan Harris & William E. Bennett. (2017) Infant Reflux in the Primary Care Setting: A Brief Educational Intervention and Management Changes. Clinical Pediatrics 57:8, pages 920-926.
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Rachel Rosen & Reza Rahbar. (2018) Proton Pump Inhibitor Use and Outcomes in Children With Respiratory Symptoms. JAMA Otolaryngology–Head & Neck Surgery 144:7, pages 555.
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Edward Mitre, Apryl Susi, Laura E. Kropp, David J. Schwartz, Gregory H. Gorman & Cade M. Nylund. (2018) Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood. JAMA Pediatrics 172:6, pages e180315.
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Jane C Bell, Francisco J Schneuer, Christopher Harrison, Lyndal Trevena, Harriet Hiscock, Adam G Elshaug & Natasha Nassar. (2018) Acid suppressants for managing gastro-oesophageal reflux and gastro-oesophageal reflux disease in infants: a national survey. Archives of Disease in Childhood, pages archdischild-2017-314161.
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Maartje M.J. Singendonk, Merit M. Tabbers, Marc A. Benninga & Miranda W. Langendam. (2018) Pediatric Gastroesophageal Reflux Disease: Systematic Review on Prognosis and Prognostic Factors. Journal of Pediatric Gastroenterology & Nutrition 66:2, pages 239-243.
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James P. Franciosi, Edward B. Mougey, Andre Williams, Roberto A. Gomez-Suarez, Cameron Thomas, Christa L. Creech, Katherine George, Diana Corao & John J. Lima. (2018) Association Between CYP2C19 * 17 Alleles and pH Probe Testing Outcomes in Children With Symptomatic Gastroesophageal Reflux . The Journal of Clinical Pharmacology 58:1, pages 89-96.
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Mario ReyesEvan PaulusCarla HronekVeronica EtingerMatt HallJoyee Vachani, Jennifer Lusk, Christopher EmersonPatty Huddleson & Ricardo A. Quinonez. (2017) Choosing Wisely Campaign: Report Card and Achievable Benchmarks of Care for Children’s Hospitals. Hospital Pediatrics 7:11, pages 633-641.
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Benjamin D. Gold, Betsy Pilmer, Jaroslaw Kierkuś, Barbara Hunt, Maria Claudia Perez & David Gremse. (2017) Dexlansoprazole for Heartburn Relief in Adolescents with Symptomatic, Nonerosive Gastro-esophageal Reflux Disease. Digestive Diseases and Sciences 62:11, pages 3059-3068.
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Maartje M.J. SingendonkAnna J. BrinkNina F. Steutel, Faridi S. van Etten-Jamaludin, Michiel P. van Wijk, Marc A. BenningaMerit M. Tabbers. (2017) Variations in Definitions and Outcome Measures in Gastroesophageal Reflux Disease: A Systematic Review. Pediatrics 140:2.
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Rachel Rosen, Paul D. Mitchell, Janine Amirault, Manali Amin, Karen Watters & Reza Rahbar. (2017) The Edematous and Erythematous Airway Does Not Denote Pathologic Gastroesophageal Reflux. The Journal of Pediatrics 183, pages 127-131.
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Martina Heinrich, Alexandra Kain, Florian Bergmann & Dietrich von Schweinitz. (2017) Parents reported reduced symptoms and improved satisfaction after fundoplication and their perceptions were an important outcome measure. Acta Paediatrica 106:1, pages 168-173.
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E.T. Jensen, R.J. Bertelsen & T. Ringel-Kulka. 2017. The Microbiota in Gastrointestinal Pathophysiology. The Microbiota in Gastrointestinal Pathophysiology 27 35 .

Licia Pensabene & Geoffrey Davidson. 2017. Esophageal and Gastric Disorders in Infancy and Childhood. Esophageal and Gastric Disorders in Infancy and Childhood 995 1013 .

M. M. J. Singendonk, M. A. Benninga & M. P. van Wijk. (2016) Reflux monitoring in children. Neurogastroenterology & Motility 28:10, pages 1452-1459.
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Howard S. Faden & Chan-Xing Ma. (2015) Trends in Oral Antibiotic, Proton Pump Inhibitor, and Histamine 2 Receptor Blocker Prescription Patterns for Children Compared With Adults. Clinical Pediatrics 55:8, pages 712-716.
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Catherine N Kirby, Ahuva Y Segal, Rupert Hinds, Kay M Jones & Leon Piterman. (2015) Infant gastro‐oesophageal reflux disease ( GORD ): A ustralian GP attitudes and practices . Journal of Paediatrics and Child Health 52:1, pages 47-53.
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Yvan Vandenplas. 2016. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition 105 130 .

Rachel Rosen, Lan Hu, Janine Amirault, Umakanth Khatwa, Doyle V. Ward & Andrew Onderdonk. (2015) 16S Community Profiling Identifies Proton Pump Inhibitor Related Differences in Gastric, Lung, and Oropharyngeal Microflora. The Journal of Pediatrics 166:4, pages 917-923.
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Guy Boeckxstaens, Hashem B El-Serag, André J P M Smout & Peter J Kahrilas. (2015) Republished: Symptomatic reflux disease: the present, the past and the future. Postgraduate Medical Journal 91:1071, pages 46-54.
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Eric R. CoonRicardo A. QuinonezVirginia A. Moyer & Alan R. Schroeder. (2014) Overdiagnosis: How Our Compulsion for Diagnosis May Be Harming Children. Pediatrics 134:5, pages 1013-1023.
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Marta Illueca, Berhanu Alemayehu, Nze Shoetan & Huiying Yang. (2014) Proton Pump Inhibitor Prescribing Patterns in Newborns and Infants. The Journal of Pediatric Pharmacology and Therapeutics 19:4, pages 283-287.
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Shelsey J. WeinsteinSamantha A. HouseChiang-Hua Chang, Jared R. Wasserman, David C. Goodman & Nancy E. Morden. (2014) Small Geographic Area Variations in Prescription Drug Use. Pediatrics 134:3, pages 563-570.
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John J Lima & James P Franciosi. (2014) Pharmacogenomic testing: the case for CYP2C19 proton pump inhibitor gene–drug pairs . Pharmacogenomics 15:11, pages 1405-1416.
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Guy Boeckxstaens, Hashem B El-Serag, André J P M Smout & Peter J Kahrilas. (2014) Symptomatic reflux disease: the present, the past and the future. Gut 63:7, pages 1185-1193.
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Robert S. ValetKecia N. Carroll, Tebeb Gebretsadik, Patricia A. MintonKimberly B. WoodwardZhouwen Liu & Tina V. Hartert. (2014) Gastroesophageal Reflux Disease Increases Infant Acute Respiratory Illness Severity, but not Childhood Asthma. Pediatric Allergy, Immunology, and Pulmonology 27:1, pages 30-33.
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Yvan Vandenplas. (2013) Management of paediatric GERD. Nature Reviews Gastroenterology & Hepatology 11:3, pages 147-157.
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Pauline De Bruyne, Thierry Christiaens, Robert Vander Stichele & Myriam Van Winckel. (2014) Changes in Prescription Patterns of Acid-Suppressant Medications by Belgian Pediatricians. Journal of Pediatric Gastroenterology & Nutrition 58:2, pages 220-225.
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David Forbes, Alicia Lim & Madhur Ravikumara. (2013) Gastroesophageal reflux in the 21st century. Current Opinion in Pediatrics 25:5, pages 597-603.
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M. J. Smits, C. M. Loots, M. A. Benninga, T. I. Omari & M. P. van Wijk. (2013) New Insights in Gastroesophageal Reflux, Esophageal Function and Gastric Emptying in Relation to Dysphagia Before and After Anti-Reflux Surgery in Children. Current Gastroenterology Reports 15:10.
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Anita Trikha, Jacques G. Baillargeon, Yong-fang Kuo, Alai Tan, Karen Pierson, Gulshan Sharma, Gregg Wilkinson & Rana S. Bonds. (2013) Development of food allergies in patients with Gastroesophageal Reflux Disease treated with gastric acid suppressive medications. Pediatric Allergy and Immunology 24:6, pages 582-588.
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Ricardo A. Quinonez, Matthew D. Garber, Alan R. Schroeder, Brian K. Alverson, Wendy Nickel, Jenna Goldstein, Jeffrey S. Bennett, Bryan R. Fine, Timothy H. Hartzog, Heather S. McLean, Vineeta Mittal, Rita M. Pappas, Jack M. Percelay, Shannon C. Phillips, Mark Shen & Shawn L. Ralston. (2013) Choosing wisely in pediatric hospital medicine: Five opportunities for improved healthcare value. Journal of Hospital Medicine 8:9, pages 479-485.
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Francisco A. Sylvester & Erica L. Wynn. 2013. Pediatric Drug Development. Pediatric Drug Development 396 408 .

Forssell Lina, Cnattingius Sven, Bottai Matteo, Edstedt Bonamy Anna-Karin, Lagergren Jesper, Agréus Lars & Akre Olof. (2013) Risk of oesophageal adenocarcinoma among individuals born preterm or small for gestational age. European Journal of Cancer 49:9, pages 2207-2213.
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Laura D. Scherer, Brian J. Zikmund-FisherAngela Fagerlin & Beth A. Tarini. (2013) Influence of “GERD” Label on Parents’ Decision to Medicate Infants. Pediatrics 131:5, pages 839-845.
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André SchultzAndrew C. Martin. (2013) Outpatient Management of Asthma in Children. Clinical Medicine Insights: Pediatrics 7, pages CMPed.S7867.
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V Shakhnovich, R M Ward & G L Kearns. (2012) Failure of Proton Pump Inhibitors to Treat GERD in Neonates and Infants: A Question of Drug, Diagnosis, or Design. Clinical Pharmacology & Therapeutics 92:3, pages 388-392.
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Kathryn BlakeHengameh Raissy. (2012) Treatment of Pediatric Asthma with Proton Pump Inhibitors: Three Strikes, Game Over. Pediatric Allergy, Immunology, and Pulmonology 25:2, pages 119-122.
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Matthew W. Carroll & Kevan Jacobson. (2012) Gastroesophageal Reflux Disease in Children and Adolescents. Pediatric Drugs 14:2, pages 79-89.
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Troy E. Gibbons, Sowmya N. Patil, Juliana C. Frem, Chandra Smith, Josephine Wakwe & Christopher J. Swearingen. (2011) Non-IgE-Mediated Cow Milk Allergy Is Linked to Early Childhood Clusters of Commonly Seen Illnesses. Clinical Pediatrics 51:4, pages 337-344.
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Charles W. DeBrosse, James P. Franciosi, Eileen C. King, Bridget K. Buckmeier Butz, Allison B. Greenberg, Margaret H. Collins, J. Pablo Abonia, Amal Assa’ad, Philip E. Putnam & Marc E. Rothenberg. (2011) Long-term outcomes in pediatric-onset esophageal eosinophilia. Journal of Allergy and Clinical Immunology 128:1, pages 132-138.
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Peter N Zannikos, Dennis R Doose, Gerhard J Leitz, Sarah Rusch, Martha D Gonzalez, Bhavna Solanki, Ibrahim Haddad & Andrew E Mulberg. (2011) Pharmacokinetics and Tolerability of Rabeprazole in Children 1 to 11 Years Old With Gastroesophageal Reflux Disease. Journal of Pediatric Gastroenterology & Nutrition 52:6, pages 691-701.
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Rachel J. van der PolMarije J. SmitsMichiel P. van WijkTaher I. Omari, Merit M. TabbersMarc A. Benninga. (2011) Efficacy of Proton-Pump Inhibitors in Children With Gastroesophageal Reflux Disease: A Systematic Review. Pediatrics 127:5, pages 925-935.
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Hayat M Mousa, Rachel Rosen, Frederick W Woodley, Marina Orsi, Daneila Armas, Christophe Faure, John Fortunato, Judith O'Connor, Beth Skaggs & Samuel Nurko. (2011) Esophageal Impedance Monitoring for Gastroesophageal Reflux. Journal of Pediatric Gastroenterology & Nutrition 52:2, pages 129-139.
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Sait Sager, Metin Halac, Nalan Selcuk, Ismail Dogan, Levent Kabasakal, Cetin Onsel & Ilhami Uslu. (2010) Temporal relationship between gastroesophageal reflux and rate of gastric emptying in children. Nuclear Medicine Communications 31:12, pages 1059-1062.
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O. Mouterde, M. Bellaïche, C. Dumant & E. Mallet. (2010) Reflux gastro-œsophagien (RGO) et inhibiteurs de la pompe à proton (IPP) chez l’enfant : panacée ou abus ?. Archives de Pédiatrie 17:6, pages 739-740.
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Pediatric gastroesophageal reflux disease and acid-related conditions: trends in incidence of diagnosis and acid suppression therapy

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Pediatric gastroesophageal reflux disease and acid-related conditions: trends in incidence of diagnosis and acid suppression therapy

Citations (63)

Articles from other publishers (63)

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