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Gastroenterology: Original Articles

Prevalence and impact of constipation and bowel dysfunction induced by strong opioids: a cross-sectional survey of 520 patients with cancer pain: DYONISOS study

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Pages 1423-1433 | Accepted 27 Sep 2013, Published online: 25 Oct 2013

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Read on this site (7)

Stephanie C Yoon & Heather C Bruner. (2017) Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Preference and Adherence 11, pages 1265-1271.
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Gineke Koopmans-Klein, Joeri Van Op den Bosch, Yvonne van Megen, Hans Prenen, Frank Huygen & Isabelle Mancini. (2017) Prolonged release oxycodone and naloxone treatment counteracts opioid-induced constipation in patients with severe pain compared to previous analgesic treatment. Current Medical Research and Opinion 33:12, pages 2217-2227.
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Gineke Koopmans-Klein, Michel F.M. Wagemans, Hans C.H. Wartenberg, Yvonne J.B. Van Megen & Frank J.P.M. Huygen. (2016) The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study. Expert Review of Gastroenterology & Hepatology 10:4, pages 547-553.
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Amir Rumman, Zane R. Gallinger & Louis W. C. Liu. (2016) Opioid induced constipation in cancer patients: pathophysiology, diagnosis and treatment. Expert Review of Quality of Life in Cancer Care 1:1, pages 25-35.
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Heather C Bruner, Rabia S Atayee, Kyle P Edmonds & Gary T Buckholz. (2015) Clinical utility of naloxegol in the treatment of opioid-induced constipation. Journal of Pain Research 8, pages 289-294.
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Wojciech Leppert. (2015) Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction. Drug Design, Development and Therapy 9, pages 2215-2231.
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Gineke Koopmans, Karen Simpson, Javier De Andrés, Eberhard Albert Lux, Michel Wagemans & Yvonne Van Megen. (2014) Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives. Current Medical Research and Opinion 30:11, pages 2389-2396.
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Crossref
Joseph V. Pergolizzi Jr. Robert B. Raffa, Emilio Esteban Gonzalez & Jo Ann LeQuang. (2017) A Guide for Cancer Pain Management in Latin America. Journal of Cancer Research Updates 6:4, pages 81-96.
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Robert S. Epstein, J. Russell Teagarden, Ali Cimen, Mark Sostek & Tehseen Salimi. (2017) When People with Opioid-Induced Constipation Speak: A Patient Survey. Advances in Therapy 34:3, pages 725-731.
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Stefan Müller-Lissner, Gabrio Bassotti, Benoit Coffin, Asbjørn Mohr Drewes, Harald Breivik, Elon Eisenberg, Anton Emmanuel, Françoise Laroche, Winfried Meissner & Bart Morlion. (2016) Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. Pain Medicine, pages pnw255.
Crossref
Rachel M. McQuade, Vanesa Stojanovska, Raquel Abalo, Joel C. Bornstein & Kulmira Nurgali. (2016) Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments. Frontiers in Pharmacology 7.
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Nancy Y. ChenEugene Nguyen, Sheree M. Schrager & Christopher J. Russell. (2016) Factors Associated With the Prophylactic Prescription of a Bowel Regimen to Prevent Opioid-Induced Constipation. Hospital Pediatrics 6:11, pages 677-683.
Crossref
Mei Krishnasamy & Raymond J. Chan. (2016) Translational Cancer Nursing Research. Cancer Nursing 39:6, pages 425-426.
Crossref
Claire Gervais, Philippe Ducrotté, Thierry Piche, Mario Di Palma, Nicolas Jovenin & Florian Scotté. (2016) Constipation et cancer : stratégies actuelles. Bulletin du Cancer 103:9, pages 794-804.
Crossref
Sita Chokhavatia, Elizabeth S. John, Mary Barna Bridgeman & Deepali Dixit. (2016) Constipation in Elderly Patients with Noncancer Pain: Focus on Opioid-Induced Constipation. Drugs & Aging 33:8, pages 557-574.
Crossref
Karin S. Coyne, Chris Sexton, Robert J. LoCasale, Frederic R. King, Mary Kay Margolis & Sam H. Ahmedzai. (2016) Opioid-Induced Constipation among a Convenience Sample of Patients with Cancer Pain. Frontiers in Oncology 6.
Crossref
Irene Sonu, George Triadafilopoulos & Jerry D Gardner. (2016) Persistent constipation and abdominal adverse events with newer treatments for constipation. BMJ Open Gastroenterology 3:1, pages e000094.
Crossref
Helene Nordahl Christensen, Urban Olsson, Jesper From & Harald Breivik. (2016) Opioid-induced constipation, use of laxatives, and health-related quality of life. Scandinavian Journal of Pain 11:1, pages 104-110.
Crossref
M. Nilsson, T. H. Sandberg, J. L. Poulsen, M. Gram, J. B. Frøkjaer, L. R. Østergaard, K. Krogh, C. Brock & A. M. Drewes. (2015) Quantification and variability in colonic volume with a novel magnetic resonance imaging method. Neurogastroenterology & Motility 27:12, pages 1755-1763.
Crossref
R. J. LoCasale, C. J. Datto, M. K. Margolis, J. Tack & K. S. Coyne. (2015) The impact of opioid-induced constipation among chronic pain patients with sufficient laxative use. International Journal of Clinical Practice 69:12, pages 1448-1456.
Crossref
Lynn R. Webster. (2015) Opioid-Induced Constipation. Pain Medicine 16:suppl 1, pages S16-S21.
Crossref
Bart Morlion, Katri Elina Clemens & Will Dunlop. (2014) Quality of Life and Healthcare Resource in Patients Receiving Opioids for Chronic Pain: A Review of the Place of Oxycodone/Naloxone. Clinical Drug Investigation 35:1, pages 1-11.
Crossref
. 2014. Kratom and Other Mitragynines. Kratom and Other Mitragynines 274 297 .
Xiao Li, Guoqi Li, Shaoling Wu, Baiyu Zhang, Qing Wan, Ding Yu, Ruijun Zhou & Chao Ma. (2014) Antinociceptive Effect of Intrathecal Microencapsulated Human Pheochromocytoma Cell in a Rat Model of Bone Cancer Pain. International Journal of Molecular Sciences 15:7, pages 12135-12148.
Crossref

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