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Clinical Focus: Diabetes, Hypertension, and Heart Disease

Overview of the Gliptin Class (Dipeptidyl Peptidase-4 Inhibitors) in Clinical Practice

, MD
Pages 40-45 | Published online: 13 Mar 2015

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Roberto Costante, Azzurra Stefanucci, Simone Carradori, Ettore Novellino & Adriano Mollica. (2015) DPP-4 inhibitors: a patent review (2012 – 2014). Expert Opinion on Therapeutic Patents 25:2, pages 209-236.
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Robert J. Greene, Hua Tu, John P. Gibbs & J. Greg Slatter. (2011) Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222. Xenobiotica 41:11, pages 945-957.
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Yutaka Seino, Tetsuya Fujita, Shinzo Hiroi, Masashi Hirayama & Kohei Kaku. (2011) Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study. Current Medical Research and Opinion 27:9, pages 1781-1792.
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Anna I. Palalau, Abd A. Tahrani, Milan K. Piya & Anthony H. Barnett. (2009) DPP-4 Inhibitors in Clinical Practice. Postgraduate Medicine 121:6, pages 70-100.
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Articles from other publishers (27)

Marija Drakul, Sergej Tomić, Marina Bekić, Dušan Mihajlović, Miloš Vasiljević, Sara Rakočević, Jelena Đokić, Nikola Popović, Dejan Bokonjić & Miodrag Čolić. (2023) Sitagliptin Induces Tolerogenic Human Dendritic Cells. International Journal of Molecular Sciences 24:23, pages 16829.
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Abeer Rashad Derar, Neven Ahmed & Emad Mohamed Hussien. (2023) A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors. BMC Chemistry 17:1.
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R. Pelluri, S. Kongara, V. R. Nagasubramanian, S. Mahadevan & J. Chimakurthy. (2023) Systematic review and meta-analysis of teneligliptin for treatment of type 2 diabetes. Journal of Endocrinological Investigation 46:5, pages 855-867.
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Sheila Owens-Collins. 2023. Beta-Cells in Health and Disease [Working Title]. Beta-Cells in Health and Disease [Working Title].
Jiuxiang Liu, Qiang Zuo, Zhi Li, Jiangqi Chen & Feng Liu. (2021) Trelagliptin ameliorates IL-1β-impaired chondrocyte function via the AMPK/SOX-9 pathway. Molecular Immunology 140, pages 70-76.
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Pranav Shah, Kejal Chavda, Bhavin Vyas & Shailaja Patel. (2020) Formulation development of linagliptin solid lipid nanoparticles for oral bioavailability enhancement: role of P-gp inhibition. Drug Delivery and Translational Research 11:3, pages 1166-1185.
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I. V. Glinkina, A. V. Balashova, A. S. Shyman, A. V. Oderij, S. A. KhanG. E. Runova, T. B. Morgunova & V. V. Fadeev. (2021) Factors determining the clinical significance of dipeptidyl peptidase-4 inhibitors in the treatment of elderly patients with type 2 diabetes mellitus. Meditsinskiy sovet = Medical Council:7, pages 56-67.
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Guang Wang, Bing Wu, Lening Zhang, Xuefei Jin, Kun Wang, Wenzhou Xu, Bo Zhang & Heyuan Wang. (2021) The protective effects of trelagliptin on high‐fat diet‐induced nonalcoholic fatty liver disease in mice. Journal of Biochemical and Molecular Toxicology 35:4.
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Amal M Mohamad, Cenk A Andac & Sena Caglar Andac. (2020) Cross Referencing 2D-LC Determination of Intact Gliptins in Urine. Journal of Chromatographic Science 58:10, pages 907-914.
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Richard Ofori-Asenso, Jenni Ilomaki, K.L. Chin, Mohsen Mazidi, Ella Zomer, J.S. Bell, Dianna J. Magliano & Danny Liew. (2019) Dynamics of switching, adherence, and persistence of dipeptidyl peptidase-4 inhibitors use: A nationwide cohort study. Diabetes Research and Clinical Practice 158, pages 107909.
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E. V. Biryukova. (2019) Clinical aspects and prospects of using DPP-4 inhibitors. Medical Council:4, pages 24-29.
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Ola M. Abdalla, Ahmed M. Abdel-Megied, Ahmed S. Saad & Shymaa S. Soliman. (2018) Simultaneous spectrophotometric determination of compounds having relatively disparate absorbance and concentration ranges; application to antidiabetic formulation of linagliptin and metformin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 203, pages 112-117.
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Piyush Agarwal, Chhavi Jindal & Vinayak Sapakal. (2018) Efficacy and safety of teneligliptin in Indian patients with inadequately controlled Type 2 diabetes mellitus: A randomized, double-blind study. Indian Journal of Endocrinology and Metabolism 22:1, pages 41.
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Antonio Riva, Melissa Laird, Armanda Casrouge, Arvydas Ambrozaitis, Roger Williams, Nikolai V. Naoumov, Matthew L. Albert & Shilpa Chokshi. (2014) Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection. Hepatology 60:2, pages 487-496.
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Charbel Abi Khalil & Shahrad Taheri. 2014. Molecular Mechanisms Underpinning the Development of Obesity. Molecular Mechanisms Underpinning the Development of Obesity 179 194 .
Maciej Sałaga, Marta Sobczak & Jakub Fichna. (2013) Inhibition of proteases as a novel therapeutic strategy in the treatment of metabolic, inflammatory and functional diseases of the gastrointestinal tract. Drug Discovery Today 18:15-16, pages 708-715.
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E. Araki, R. Kawamori, N. Inagaki, H. Watada, N. Hayashi, Y. Horie, A. Sarashina, S. Thiemann, M. von Eynatten, K. Dugi & H.‐J. Woerle. (2012) Long‐term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes. Diabetes, Obesity and Metabolism 15:4, pages 364-371.
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Thomas Rauch, Ulrike Graefe-Mody, Carolyn F. Deacon, Arne Ring, Jens J. Holst, Hans-Juergen Woerle, Klaus A. Dugi & Tim Heise. (2012) Linagliptin Increases Incretin Levels, Lowers Glucagon, and Improves Glycemic Control in Type 2 Diabetes Mellitus. Diabetes Therapy 3:1.
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Y. Seino, Y. Miyata, S. Hiroi, M. Hirayama & K. Kaku. (2012) Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double‐blind, placebo‐controlled trial with an open‐label, long‐term extension study. Diabetes, Obesity and Metabolism 14:10, pages 927-936.
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T. Haak, T. Meinicke, R. Jones, S. Weber, M. von Eynatten & H.‐J. Woerle. (2012) Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double‐blind, placebo‐controlled study. Diabetes, Obesity and Metabolism 14:6, pages 565-574.
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Pradip Jadav, Rajesh Bahekar, Shailesh R. Shah, Dipam Patel, Amit Joharapurkar, Samadhan Kshirsagar, Mukul Jain, Mubeen Shaikh & Kalapatapu V.V.M. Sairam. (2012) Long-acting peptidomimetics based DPP-IV inhibitors. Bioorganic & Medicinal Chemistry Letters 22:10, pages 3516-3521.
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Holger Fuchs, Frank Runge & Heinz-Dieter Held. (2012) Excretion of the dipeptidyl peptidase-4 inhibitor linagliptin in rats is primarily by biliary excretion and P-gp-mediated efflux. European Journal of Pharmaceutical Sciences 45:5, pages 533-538.
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D. R. Owens, R. Swallow, K. A. Dugi & H. J. Woerle. (2011) Efficacy and safety of linagliptin in persons with Type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study1. Diabetic Medicine 28:11, pages 1352-1361.
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R. Gomis, R.-M. Espadero, R. Jones, H. J. Woerle & K. A. Dugi. (2011) Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes, Obesity and Metabolism 13:7, pages 653-661.
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S. Del Prato, A. H. Barnett, H. Huisman, D. Neubacher, H.-J. Woerle & K. A. Dugi. (2011) Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes, Obesity and Metabolism 13:3, pages 258-267.
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Rudy Bilous & Richard Donnelly. 2010. Handbook of Diabetes. Handbook of Diabetes 79 86 .
B. Gallwitz & H.‐U. Häring. (2009) Future perspectives for insulinotropic agents in the treatment of type 2 diabetes–DPP‐4 inhibitors and sulphonylureas. Diabetes, Obesity and Metabolism 12:1, pages 1-11.
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