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Postgraduate Medicine Volume 121, 2009 - Issue 1
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Clinical Focus: Diabetes, Hypertension, and Heart Disease

Impact of Incretin Therapy on Islet Dysfunction: An Underlying Defect in the Pathophysiology of Type 2 Diabetes

Janet B. McGill Division of Endocrinology, Metabolism, and Lipid Research, Washington University in St. Louis, St. Louis, MOCorrespondence[email protected]
, MD
Pages 46-58 | Published online: 13 Mar 2015

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Read on this site (4)

Gregory Peterson. (2012) Current treatments and strategies for type 2 diabetes: Can we do better with GLP-1 receptor agonists?. Annals of Medicine 44:4, pages 338-349.
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Jeff Unger & Christopher G. Parkin. (2010) Type 2 Diabetes: An Expanded View of Pathophysiology and Therapy. Postgraduate Medicine 122:3, pages 145-157.
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Anna I. Palalau, Abd A. Tahrani, Milan K. Piya & Anthony H. Barnett. (2009) DPP-4 Inhibitors in Clinical Practice. Postgraduate Medicine 121:6, pages 70-100.
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Janet B. McGill. (2009) Insights from the Liraglutide Clinical Development Program—the Liraglutide Effect and Action in Diabetes (LEAD) Studies. Postgraduate Medicine 121:3, pages 16-25.
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Articles from other publishers (10)

Yanqing Zhang, Meifen Wu, Wynn Htun, Emily W. Dong, Franck Mauvais-Jarvis, Vivian A. Fonseca & Hongju Wu. (2017) Differential Effects of Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors. Scientific Reports 7:1.
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Agnieszka Strózik, Arkadiusz Stęposz, Marcin Basiak, Magdalena Drożdż & Bogusław Okopień. (2015) Multifactorial effects of vildagliptin added to ongoing metformin therapy in patients with type 2 diabetes mellitus. Pharmacological Reports 67:1, pages 24-31.
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J J Holst. (2013) Incretin hormones and the satiation signal. International Journal of Obesity 37:9, pages 1161-1168.
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Jeff Unger, Debbie Hinnen, Barbara Schreiner & Chris Parkin. (2013) Putting medications where they belong: Practical advice for managing type 2 diabetes in clinical practice. Journal of the American Academy of Nurse Practitioners 25:2, pages 65-76.
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Lucio Vilar, Amaro Gusmão, José Luciano Albuquerque, Lisete Pontes, Larissa Montenegro, Soraya Pontes, George Robson Ibiapina, Rodrigo Andrade Cunha, Gercivan dos Santos Alves, Viviane Canadas, Vera Maria Santos G. Ferreira, Lucia Helena Coelho Nóbrega & Josivan Gomes de Lima. (2011) Effectiveness of adding vildagliptin to the treatment of diabetic patients nonresponsive to the combination of metformin and a sulphonylurea. Arquivos Brasileiros de Endocrinologia & Metabologia 55:4, pages 260-265.
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R. Keith Campbell. (2011) Clarifying the Role of Incretin-Based Therapies in the Treatment of Type 2 Diabetes Mellitus. Clinical Therapeutics 33:5, pages 511-527.
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Jeffrey S. Freeman. (2010) A Physiologic and Pharmacological Basis for Implementation of Incretin Hormones in the Treatment of Type 2 Diabetes Mellitus. Mayo Clinic Proceedings 85:12, pages S5-S14.
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Satish K. Garg. (2010) The Role of Basal Insulin and Glucagon-Like Peptide-1 Agonists in the Therapeutic Management of Type 2 Diabetes—A Comprehensive Review. Diabetes Technology & Therapeutics 12:1, pages 11-24.
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Priscilla Hollander, Jia Li, Elsie Allen & Roland Chen. (2009) Saxagliptin Added to a Thiazolidinedione Improves Glycemic Control in Patients with Type 2 Diabetes and Inadequate Control on Thiazolidinedione Alone. The Journal of Clinical Endocrinology & Metabolism 94:12, pages 4810-4819.
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John White. (2009) Efficacy and safety of incretin-based therapies: Clinical trial data. Journal of the American Pharmacists Association 49:5, pages S30-S40.
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