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Postgraduate Medicine Volume 126, 2014 - Issue 5
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Clinical Features

Effectiveness of Oral and Topical Hydrogen for Sports-Related Soft Tissue Injuries

Sergej M. Ostojic Center for Health, Exercise, and Sport Sciences, Stari DIF, Belgrade, Serbia; Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, SerbiaCorrespondence[email protected]
, MD, PhD,
Boris Vukomanovic Center for Health, Exercise, and Sport Sciences, Stari DIF, Belgrade, Serbia; Institute of Orthopaedic-Surgical Diseases “Banjica,” Belgrade, Serbia
, MD,
Julio Calleja-Gonzalez Center for Health, Exercise, and Sport Sciences, Stari DIF, Belgrade, Serbia; Faculty of Sport Sciences, University of the Basque Country, Vitoria-Gasteiz, Spain
, PhD &
Jay R. Hoffman Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL
, PhD, FACSM, FNSCA
Pages 188-196 | Published online: 13 Mar 2015

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Dejan Javorac, Valdemar Stajer, Laszlo Ratgeber, Andras Olah, Jozsef Betlehem, Pongras Acs, Boris Vukomanovic & Sergej M. Ostojic. (2021) Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial. Research in Sports Medicine 29:6, pages 517-525.
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Sergej M. Ostojic. (2017) Mitochondria-targeted nutraceuticals in sports medicine: a new perspective. Research in Sports Medicine 25:1, pages 91-100.
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Sergej M. Ostojic. (2015) Molecular hydrogen: An inert gas turns clinically effective. Annals of Medicine 47:4, pages 301-304.
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Articles from other publishers (30)

Hennie Marie Johnsen, Marianne Hiorth & Jo Klaveness. (2023) Molecular Hydrogen Therapy—A Review on Clinical Studies and Outcomes. Molecules 28:23, pages 7785.
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Szu-Han Chiu, Frank L. Douglas, Jia-Ru Chung, Kuang-Yih Wang, Chao-Fang Chu, Hsia-Yun Chou, Wei-Chih Huang, Tian-Yu Wang, Wen-Wen Chen, Min-Chung Shen, Feng-Cheng Liu & Po-Jen Hsiao. (2023) Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study. Frontiers in Nutrition 10.
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Ishrat Perveen, Bakhtawar Bukhari, Mahwish Najeeb, Sumbal Nazir, Tallat Anwar Faridi, Muhammad Farooq, Qurat-ul-Ain Ahmad, Manal Abdel Haleem A. Abusalah, Thana’ Y. ALjaraedah, Wesal Yousef Alraei, Ali A. Rabaan, Kirnpal Kaur Banga Singh & Mai Abdel Haleem A. Abusalah. (2023) Hydrogen Therapy and Its Future Prospects for Ameliorating COVID-19: Clinical Applications, Efficacy, and Modality. Biomedicines 11:7, pages 1892.
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Md. Habibur Rahman, Eun-Sook Jeong, Hae Sun You, Cheol-Su Kim & Kyu-Jae Lee. (2023) Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity. Antioxidants 12:5, pages 988.
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Tyler W. LeBaron, Kinji Ohno & John T. Hancock. (2023) The On/Off History of Hydrogen in Medicine: Will the Interest Persist This Time Around?. Oxygen 3:1, pages 143-162.
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Pathik Sahoo. (2023) Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries. Current Topics in Medicinal Chemistry 23:4, pages 249-256.
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John T. Hancock, Grace Russell, Tim J. Craig, Jennifer May, H. Ruth Morse & Jonathan S. Stamler. (2022) Understanding Hydrogen: Lessons to Be Learned from Physical Interactions between the Inert Gases and the Globin Superfamily. Oxygen 2:4, pages 578-590.
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Duried ALWAZEER & Sümeyra ÇİÇEK. (2022) MOLEKÜLER HİDROJENİN SAĞLIK ALANINDA KULLANIMIUSE OF MOLECULAR HYDROGEN IN HEALTH FIELD. Karya Journal of Health Science 3:1, pages 30-34.
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Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, Jing Qiao & Youzhen Wei. (2021) Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Frontiers in Physiology 12.
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Grace Russell, Alexander Nenov, Hesham Kisher & John T. Hancock. (2021) Molecular Hydrogen as Medicine: An Assessment of Administration Methods. Hydrogen 2:4, pages 444-460.
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Yingning Li, Zhen Wang, Naqi Lian, Yuzun Wang, Weiqiang Zheng & Keliang Xie. (2021) Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19. Frontiers in Medicine 8.
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Ahmad Osailan, Abdulaziz Jamaan, Khalid Talha & Mshari Alhndi. (2021) Instrument assisted soft tissue mobilization (IASTM) versus stretching: A comparison in effectiveness on hip active range of motion, muscle torque and power in people with hamstring tightness. Journal of Bodywork and Movement Therapies 27, pages 200-206.
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Tyler W. LeBaron, Jason Kharman & Michael McCullough. (2021) Hydro Shot for Sports Performance and Exercise Medicine. The Journal of Science and Medicine 3:2, pages 1-15.
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N. Jafta, S. Magagula, K. Lebelo, D. Nkokha & M.J. Mochane. 2021. Applied Water Science Volume 1. Applied Water Science Volume 1 273 298 .
Chaoqun Nie, Xue Ding, Rong A, Min Zheng, Zhenning Li, Shuang Pan & Wei Yang. (2021) Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats. Life Sciences 272, pages 119248.
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Alex Tarnava. (2021) Supersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report. The Journal of Science and Medicine 2:4.
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Nikola Todorovic, Dejan Javorac, Valdemar Stajer & Sergej M. Ostojic. (2020) The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise. Journal of Sports Medicine 2020, pages 1-5.
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. (2020) Withdrawn: Influence of instrument assisted soft tissue techniques versus active soft tissue therapies on latent trigger point of upper trapezius muscle: Randomized clinical study. Physiotherapy Research International.
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Cheong Hwa OoiSiew Kit NgEshaifol Azam Omar. (2020) Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes. Applied Physiology, Nutrition, and Metabolism 45:5, pages 513-519.
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Dejan Javorac, Valdemar Stajer & Sergej Ostojic. (2020) Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete. F1000Research 9, pages 245.
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Tyler W. LeBaronIsmail LaherBranislav KuraJan Slezak. (2019) Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Canadian Journal of Physiology and Pharmacology 97:9, pages 797-807.
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Santiago Marcelo d’Almeida, Rodrigo Marcel Valentim da Silva & Oscar Ariel Ronzio. (2019) Nivel de satisfacción sobre la seguridad y complicaciones a cuatro años de la introducción de la técnica Microelectrólisis Percutánea (MEP®) Sport como práctica fisioterapéutica. Fisioterapia e Pesquisa 26:2, pages 190-195.
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Vladimir I. Klichko, Vladimir L. Safonov, Marina Yu. Safonov & Svetlana N. Radyuk. (2019) Supplementation with hydrogen-producing composition confers beneficial effects on physiology and life span in Drosophila. Heliyon 5:5, pages e01679.
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Alexis R. Cole, Dorothy A. Perry, Ali Raza, Arthur P. Nedder, Elizabeth Pollack, William L. Regan, Sarah J. van den Bosch, Brian D. Polizzotti, Edward Yang, Daniel Davila, Onur Afacan, Simon K. Warfield, Yangming Ou, Brenda Sefton, Allen D. Everett, Jeffrey J. Neil, Hart G.W. Lidov, John E. Mayer & John N. Kheir. (2019) Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC: Basic to Translational Science 4:2, pages 176-187.
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Hideo Ogawa, Masahiro Okada, Masachika Shudou, Kiyofumi Gyo & Naohito Hato. (2018) Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil. Neuroscience Letters 665, pages 195-199.
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Jooyoung Kim, Dong Jun Sung & Joohyung Lee. (2017) Therapeutic effectiveness of instrument-assisted soft tissue mobilization for soft tissue injury: mechanisms and practical application. Journal of Exercise Rehabilitation 13:1, pages 12-22.
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Garth L. Nicolson, Gonzalo Ferreira de Mattos, Robert Settineri, Carlos Costa, Rita Ellithorpe, Steven Rosenblatt, James La Valle, Antonio Jimenez & Shigeo Ohta. (2016) Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine. International Journal of Clinical Medicine 07:01, pages 32-76.
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Sergej M. Ostojic. (2016) Should hydrogen therapy be included in a musculoskeletal medicine routine?. F1000Research 5, pages 2659.
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Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama & Kinji Ohno. (2015) Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -. Medical Gas Research 5:1.
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Sergej M. Ostojic. (2015) Targeting molecular hydrogen to mitochondria: Barriers and gateways. Pharmacological Research 94, pages 51-53.
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