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Clinical Focus: Thrombosis and Cardiovascular Medicine

Reversal Agents in Development for the New Oral Anticoagulants

, MD, , MD, , PhD, , PhD & , PhD

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Antonia-Therese Kietaibl & Sibylle Kietaibl. (2019) New Hemostatic Agents: Perioperative Anesthetic Considerations. Current Pharmaceutical Design 25:19, pages 2158-2164.
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Deborah K. Rose & Barak Bar. (2018) Direct Oral Anticoagulant Agents: Pharmacologic Profile, Indications, Coagulation Monitoring, and Reversal Agents. Journal of Stroke and Cerebrovascular Diseases 27:8, pages 2049-2058.
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Andreas Zirlik & Christoph Bode. (2016) Vitamin K antagonists: relative strengths and weaknesses vs. direct oral anticoagulants for stroke prevention in patients with atrial fibrillation. Journal of Thrombosis and Thrombolysis 43:3, pages 365-379.
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Masahiro Yasaka. 2017. Treatment of Non-vitamin K Antagonist Oral Anticoagulants. Treatment of Non-vitamin K Antagonist Oral Anticoagulants 25 39 .
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Savino Sciascia, Chary Lopez-Pedrera, Irene Cecchi, Clara Pecoraro, Dario Roccatello & Maria Josè Cuadrado. (2016) Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome. Rheumatology 55:10, pages 1726-1735.
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James A. Reiffel, Jeffrey I. Weitz, Paul Reilly, Edvardas Kaminskas, Troy Sarich, Philip Sager & Jonathan Seltzer. (2016) NOAC monitoring, reversal agents, and post-approval safety and effectiveness evaluation: A cardiac safety research consortium think tank. American Heart Journal 177, pages 74-86.
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Jack E. Ansell. (2016) Reversing the Effect of Oral Anticoagulant Drugs: Established and Newer Options. American Journal of Cardiovascular Drugs 16:3, pages 163-170.
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Anand Patel, Richard P. Goddeau Jr & Nils Henninger. (2016) Newer Oral Anticoagulants: Stroke Prevention and Pitfalls. The Open Cardiovascular Medicine Journal 10:1, pages 94-104.
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Jack E. Ansell. (2015) Universal, class-specific and drug-specific reversal agents for the new oral anticoagulants. Journal of Thrombosis and Thrombolysis 41:2, pages 248-252.
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Richard C. Becker. (2015) The biochemistry, enzymology and pharmacology of non-vitamin K anticoagulant drug reversal agents and antidotes. Journal of Thrombosis and Thrombolysis 41:2, pages 273-278.
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Hiroyuki Hamada, Shinichi Wada, Yohei Mima, Masahiro Yasaka, Takahiro Kuwashiro & Yasushi Okada. (2016) A case of thalamic hemorrhage which occurred during anticoagulant therapy with Xa inhibitor and expanded even after the administration of prothrombin complex concentrate. Nosotchu 38:6, pages 413-417.
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Alessandro Di Minno, Gaia Spadarella, Emanuela Spadarella, Elena Tremoli & Giovanni Di Minno. (2015) Gastrointestinal bleeding in patients receiving oral anticoagulation: Current treatment and pharmacological perspectives. Thrombosis Research 136:6, pages 1074-1081.
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Celeste B. Burness. (2015) Idarucizumab: First Global Approval. Drugs 75:18, pages 2155-2161.
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Charles André. (2015) Preventing bleeding and thromboembolic complications in atrial fibrillation patients undergoing surgery. Arquivos de Neuro-Psiquiatria 73:8, pages 704-713.
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Hiroyuki Hamada, Shinichi Wada, Yohei Mima, Masahiro Yasaka, Takahiro Kuwashiro & Yasushi Okada. (2015) Retraction:The onset of thalamic hemorrhage in Rivaroxaban in oral IX factor complex formulation administration, but showed a hematoma expansion case. Rinsho Shinkeigaku.
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