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The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells

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Pages 884-889 | Received 23 Dec 2013, Accepted 19 Feb 2014, Published online: 21 Feb 2014

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Xiwen Liao, Xiangkun Wang, Ketuan Huang, Chengkun Yang, Tingdong Yu, Chuangye Han, Guangzhi Zhu, Hao Su, Rui Huang & Tao Peng. (2018) Genome-scale analysis to identify prognostic microRNA biomarkers in patients with early stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy. Cancer Management and Research 10, pages 2537-2551.
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Damian Jacenik, Eric J. Lebish & Ellen J. Beswick. (2023) MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target. Frontiers in Immunology 14.
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R. Pascual-Serra, D.M. Fernández-Aroca, S. Sabater, O. Roche, I. Andrés, M. Ortega-Muelas, E. Arconada-Luque, Natalia Garcia-Flores, G. Bossi, B. Belandia, M.J. Ruiz-Hidalgo & R. Sánchez-Prieto. (2021) p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models. Radiotherapy and Oncology 156, pages 136-144.
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Suresh Chava, Meher B. Gayatri & Aramati B.M. Reddy. 2019. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy 25 43 .
Yizhu Li, Frederik Köpper & Matthias Dobbelstein. (2018) Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin. Cancer Letters 428, pages 45-54.
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S J Werden, N Sphyris, T R Sarkar, A N Paranjape, A M LaBaff, J H Taube, B G Hollier, E Q Ramirez-Peña, R Soundararajan, P den Hollander, E Powell, G V Echeverria, N Miura, J T Chang, H Piwnica-Worms, J M Rosen & S A Mani. (2016) Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene 35:46, pages 5977-5988.
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Jesús García-Cano, Olga Roche, Francisco J. Cimas, Raquel Pascual-Serra, Marta Ortega-Muelas, Diego M. Fernández-Aroca & Ricardo Sánchez-Prieto. (2016) p38MAPK and Chemotherapy: We Always Need to Hear Both Sides of the Story. Frontiers in Cell and Developmental Biology 4.
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Sameer A. Dhayat, Wolf Arif Mardin, Jochen Seggewiß, Anda Jana Ströse, Christiane Matuszcak, Richard Hummel, Norbert Senninger, Sören Torge Mees & Jörg Haier. (2015) MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma. PLOS ONE 10:11, pages e0143755.
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