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Perspective

Antibodies designed as effective cancer vaccines

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Pages 71-85 | Received 30 Sep 2008, Accepted 25 Nov 2008, Published online: 01 Jan 2009

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Poulam M. Patel, Christian H. Ottensmeier, Clive Mulatero, Paul Lorigan, Ruth Plummer, Hardev Pandha, Somaia Elsheikh, Efthymios Hadjimichael, Naty Villasanti, Sally E. Adams, Michelle Cunnell, Rachael L. Metheringham, Victoria A. Brentville, Lee Machado, Ian Daniels, Mohamed Gijon, Drew Hannaman & Lindy G. Durrant. (2018) Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial. OncoImmunology 7:6.
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Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene & Lorenzo Galluzzi. (2017) Trial watch: DNA-based vaccines for oncological indications. OncoImmunology 6:12.
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Wei Xue, Rachael L. Metheringham, Victoria A. Brentville, Barbara Gunn, Peter Symonds, Hideo Yagita, Judith M. Ramage & Lindy G. Durrant. (2016) SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade. OncoImmunology 5:6.
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Lindy G Durrant, Victoria A Pudney & Ian Spendlove. (2011) Using monoclonal antibodies to stimulate antitumor cellular immunity. Expert Review of Vaccines 10:7, pages 1093-1106.
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Rukaia Almshayakhchi, Divya Nagarajan, Jayakumar Vadakekolathu, Barbara-Ann Guinn, Stephen Reeder, Victoria Brentville, Rachael Metheringham, A. Graham Pockley, Lindy Durrant & Stephanie McArdle. (2021) A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone. Frontiers in Oncology 11.
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Samantha J. Paston, Victoria A. Brentville, Peter Symonds & Lindy G. Durrant. (2021) Cancer Vaccines, Adjuvants, and Delivery Systems. Frontiers in Immunology 12.
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Silvana T. Tivadar, Richard S. McIntosh, Jia Xin Chua, Robert Moss, Tina Parsons, Abed M. Zaitoun, Srinivasan Madhusudan, Lindy G. Durrant & Mireille Vankemmelbeke. (2020) Monoclonal Antibody Targeting Sialyl-di-Lewisa–Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential. Molecular Cancer Therapeutics 19:3, pages 790-801.
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Faten A. M. Abo-Aziza, A. A. Zaki, A. El-Shemy, Sahar S. Abd Elhalem & Amany S. Amer. (2017) Immunological and histopathological changes in sheep affected with cutaneous squamous cell carcinoma and treated immunotherapeutically. Veterinary World 10:9, pages 1094-1103.
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Peter L. Stern. (2017) Is immunity in cancer the key to improving clinical outcome?: Report on the International Symposium on Immunotherapy, The Royal Society, London, UK, 12–13 May 2017. Therapeutic Advances in Vaccines 5:3, pages 55-68.
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Wei Xue, Victoria A. Brentville, Peter Symonds, Katherine W. Cook, Hideo Yagita, Rachael L. Metheringham & Lindy G. Durrant. (2016) SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors. Oncotarget 7:50.
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Victoria A. Brentville, Rachael L. Metheringham, Barbara Gunn, Peter Symonds, Ian Daniels, Mohamed Gijon, Katherine Cook, Wei Xue & Lindy G. Durrant. (2016) Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell–Mediated Antitumor Immunity. Cancer Research 76:3, pages 548-560.
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Yu-Feng Xiao, Meng-Meng Jie, Bo-Sheng Li, Chang-Jiang Hu, Rui Xie, Bo Tang & Shi-Ming Yang. (2015) Peptide-Based Treatment: A Promising Cancer Therapy. Journal of Immunology Research 2015, pages 1-13.
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Silvia Loureiro, Elena Robinson, Hongying Chen, Pongsathon Phapugrangkul, Camilo Colaco & Ian M Jones. 2012. Innovation in Vaccinology. Innovation in Vaccinology 45 63 .
Jing Xu, Xiao-Juan Zhu, Yu-Hua Li, Yang Dai, Yin-Chang Zhu, Jiang Zheng, Zhen-Qing Feng & Xiao-Hong Guan. (2011) Expression, characterization and therapeutic efficacy of chimeric Fab of anti-idiotypic antibody NP30 against Schistosoma japonicum. Acta Tropica 118:2, pages 159-164.
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Silvia Loureiro, Junyuan Ren, Pongsathon Phapugrangkul, Camilo A. Colaco, Christopher R. Bailey, Holly Shelton, Eleonora Molesti, Nigel J. Temperton, Wendy S. Barclay & Ian M. Jones. (2011) Adjuvant-Free Immunization with Hemagglutinin-Fc Fusion Proteins as an Approach to Influenza Vaccines. Journal of Virology 85:6, pages 3010-3014.
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Sanchayita Ghose, Justin Ladwig & Martin Allen. (2011) Comparison of the chromatographic properties of IgG1 and IgG2 antibody subclasses. Biotechnology and Applied Biochemistry 57:3, pages 111-116.
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Victoria A. Pudney, Rachael L. Metheringham, Barbara Gunn, Ian Spendlove, Judith M. Ramage & Lindy G. Durrant. (2010) DNA vaccination with T‐cell epitopes encoded within Ab molecules induces high‐avidity anti‐tumor CD8 + T cells . European Journal of Immunology 40:3, pages 899-910.
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Grazziela P. Figueredo & Uwe Aickelin. 2010. Artificial Immune Systems. Artificial Immune Systems 4 17 .
Grazziela P. Figueredo & Uwe Aickelin. (2010) Defining a Simulation Strategy for Cancer Immunocompetence. SSRN Electronic Journal.
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