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Review

Connexins and pannexins

Coordinating cellular communication in the testis and epididymis

Pages 325-338 | Published online: 01 Dec 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Chunhong Cai, Dan Zhao, Cao Ma, Yongbo Zhang, Xing Wu, Guanghui Wei & Dawei He. (2014) Connexin 43 expression in Sprague-Dawley rat seminiferous epithelium after in utero exposure to flutamide. Systems Biology in Reproductive Medicine 60:5, pages 257-262.
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Articles from other publishers (49)

Ana Priscila Gomes-Silva, Paloma da Cunha de Medeiros, Laís Nogueira Silva, Marcella Da Silva Araújo Santiago & Juliana Elaine Perobelli. (2023) Exposure to manganese during sertoli cell formation and proliferation disturbs early testicular development in rats. Reproductive Toxicology 120, pages 108447.
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Mustapha Najih, Ha Tuyen Nguyen & Luc J. Martin. (2022) Involvement of calmodulin-dependent protein kinase I in the regulation of the expression of connexin 43 in MA-10 tumor Leydig cells. Molecular and Cellular Biochemistry 478:4, pages 791-805.
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André Acácio Souza da Silva, Fabiane de Santi, Barry T. Hinton, Paulo Sérgio Cerri & Estela Sasso-Cerri. (2023) Venlafaxine increases aromatization, reduces apical V-ATPase in clear cells and induces increased number of mast cells and smooth muscle cells death in rat cauda epididymis. Life Sciences 315, pages 121329.
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Yanina-Yasmin Pesch, Vivien Dang, Michael John Fairchild, Fayeza Islam, Darius Camp, Priya Kaur, Christopher M. Smendziuk, Anat Messenberg, Rosalyn Carr, Ciaran R. McFarlane, Pierre-Yves Musso, Filip Van Petegem & Guy Tanentzapf. (2022) Gap junctions mediate discrete regulatory steps during fly spermatogenesis. PLOS Genetics 18:9, pages e1010417.
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Temidayo S. Omolaoye, Nour Jalaleddine, Walter D. Cardona Maya & Stefan S. du Plessis. (2022) Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?. Frontiers in Physiology 13.
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Bongki Kim & Sylvie Breton. (2022) The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis. Biology of Reproduction 106:5, pages 919-927.
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Hana Greifová, Tomáš Jambor, Katarína Tokárová, Nikola Knížatová & Norbert Lukáč. (2022) In Vitro Effect of Resveratrol Supplementation on Oxidative Balance and Intercellular Communication of Leydig Cells Subjected to Induced Oxidative Stress . Folia Biologica 70:1, pages 19-32.
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Francesco Manfrevola, Guillaume Martinez, Charles Coutton, Domenico Rocco, Karine Reynaud, Yves Le Vern, Pascal Froment, Linda Beauclair, Denise Aubert, Riccardo Pierantoni, Rosanna Chianese & Florian Guillou. (2021) Ankrd31 in Sperm and Epididymal Integrity. Frontiers in Cell and Developmental Biology 9.
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Roxanne Couture & Luc J. Martin. (2020) The transcription factors SF-1 and SOX8 cooperate to upregulate Cx43 expression in mouse TM4 sertoli cells. Biochemistry and Biophysics Reports 24, pages 100828.
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Affiefa Yawer, Eliška Sychrová, Petra Labohá, Jan Raška, Tomáš Jambor, Pavel Babica & Iva Sovadinová. (2020) Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells. Toxicology and Applied Pharmacology 404, pages 115177.
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Laura Girardet, Agathe Bernet, Ezéquiel Calvo, Denis Soulet, Charles Joly-Beauparlant, Arnaud Droit, Daniel G. Cyr & Clémence Belleannée. (2020) Hedgehog signaling pathway regulates gene expression profile of epididymal principal cells through the primary cilium. The FASEB Journal 34:6, pages 7593-7609.
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Nedenia Bonvino Stafuzza, Eliane Vianna da Costa e Silva, Rafael Medeiros de Oliveira Silva, Luiz Carlos Cesar da Costa Filho, Fernanda Battistotti Barbosa, Gustavo Guerino Macedo, Raysildo B. Lobo & Fernando Baldi. (2019) Genome‐wide association study for age at puberty in young Nelore bulls. Journal of Animal Breeding and Genetics 137:2, pages 234-244.
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L. Pardyak, A. Kaminska, M. Brzoskwinia, A. Hejmej, M. Kotula-Balak, J. Jankowski, A. Ciereszko & B. Bilinska. (2020) Differential expression of cell-cell junction proteins in the testis, epididymis, and ductus deferens of domestic turkeys (Meleagris gallopavo) with white and yellow semen. Poultry Science 99:1, pages 555-566.
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W. G. Kempinas, C. S. Borges, G. A. A. Leite, T. M. Figueiredo, M. Gregory & D. G. Cyr. (2019) Prenatal exposure to betamethasone causes intergenerational impairment of epididymal development in the rat. Andrology 7:5, pages 719-729.
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R. Sullivan, C. Légaré, J. Lamontagne‐Proulx, S. Breton & D. Soulet. (2019) Revisiting structure/functions of the human epididymis. Andrology.
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Mary Gregory & Daniel G Cyr. (2019) Effects of prostaglandin E2 on gap junction protein alpha 1 in the rat epididymis†. Biology of Reproduction 100:1, pages 123-132.
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Daniel G. Cyr & Mary Gregory. (2019) A special issue on the effects of toxicants on cellular junctions in development and reproduction. Reproductive Toxicology 83, pages 80-81.
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Firas Ghouili, Pauline Roumaud & Luc J. Martin. (2018) Gja1 expression is regulated by cooperation between SOX8/SOX9 and cJUN transcription factors in TM4 and 15P-1 Sertoli cell lines . Molecular Reproduction and Development 85:11, pages 875-886.
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Daniel G. Cyr, Julie Dufresne & Mary Gregory. (2018) Cellular junctions in the epididymis, a critical parameter for understanding male reproductive toxicology. Reproductive Toxicology 81, pages 207-219.
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Anna Hejmej & Barbara Bilinska. (2018) The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate. Reproductive Toxicology 81, pages 1-16.
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Ki-Ho Lee & Nan Hee Kim. (2018) Expressional Patterns of Connexin Isoforms in the Rat Epididymal Fat during Postnatal Development. Development & Reproduction 22:1, pages 29-38.
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Arturo Hernandez. 2018. Thyroid Hormone. Thyroid Hormone 473 500 .
Fang Fang, Ke Ni, Yiting Cai, Qian Zhao, Jin Shang, Xiaoke Zhang, Shiliang Shen & Chengliang Xiong. (2017) Busulfan administration produces toxic effects on epididymal morphology and inhibits the expression of ZO-1 and vimentin in the mouse epididymis. Bioscience Reports 37:6.
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Firas Ghouili & Luc J. Martin. (2017) Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells. Gene 635, pages 24-32.
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Ryuzo YanagimachiRobert Sullivan & Clémence Belleannée. 2017. The Sperm Cell. The Sperm Cell 73 87 .
Miao Long, Shuhua Yang, Yuan Wang, Peng Li, Yi Zhang, Shuang Dong, Xinliang Chen, Jiayi Guo, Jianbin He, Zenggui Gao & Jun Wang. (2016) The Protective Effect of Selenium on Chronic Zearalenone-Induced Reproductive System Damage in Male Mice. Molecules 21:12, pages 1687.
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Ki-Ho Lee. (2016) Effects of Exposure to Estradiol Benzoate or Flutamide at the Weaning Age on Expression of Connexins in the Caudal Epididymis of Adult Rat. Development & Reproduction 20:4, pages 349-357.
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Sameh Mosaed, Bradley H. Jacobsen & Ken Young Lin. (2016) Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia. BMC Ophthalmology 16:1.
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Jing Zhang, Shuguang Jin, Jinchang Zhao & Huan Li. (2016) Effect of dibutyl phthalate on expression of connexin 43 and testosterone production of leydig cells in adult rats. Environmental Toxicology and Pharmacology 47, pages 131-135.
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Cécile Adam & Daniel G. Cyr. (2016) Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat1. Biology of Reproduction 94:6.
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Soren Hayrabedyan, Krassimira Todorova, Asma Jabeen, Gergana Metodieva, Stavri Toshkov, Metodi V. Metodiev, Milcho Mincheff & Nelson Fernández. (2016) Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production. Scientific Reports 6:1.
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Jeremy Roy, Bongki Kim, Eric Hill, Pablo Visconti, Dario Krapf, Claudio Vinegoni, Ralph Weissleder, Dennis Brown & Sylvie Breton. (2016) Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nature Communications 7:1.
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Gerald M. Kidder & Daniel G. Cyr. (2016) Roles of connexins in testis development and spermatogenesis. Seminars in Cell & Developmental Biology 50, pages 22-30.
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Daniel G. Cyr, Patrick J. Devine & Isabelle Plante. 2016. Technical Aspects of Toxicological Immunohistochemistry. Technical Aspects of Toxicological Immunohistochemistry 113 145 .
Seong-Kyu Lee & Ki-Ho Lee. (2015) Aberrant Expression of Connexin Isoforms in the Corpus Epididymis of the Adult Rat by Exposure to Estradiol Benzoate or Flutamide at the Weaning Age. Development & Reproduction 19:4, pages 217-226.
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Marion Mandon, Louis Hermo & Daniel G. Cyr. (2015) Isolated Rat Epididymal Basal Cells Share Common Properties with Adult Stem Cells1. Biology of Reproduction 93:5.
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Ki-Ho Lee. (2015) Modification of Gene Expression of Connexins in the Rat Corpus Epididymis by Estradiol Benzoate or Flutamide Exposure at the Early Neonatal Age. Development & Reproduction 19:2, pages 69-77.
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Namarta Mahi, Amit Kumar, Amteshwar S. Jaggi, Nirmal Singh & Ravi Dhawan. (2015) Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice. Journal of Surgical Research 196:1, pages 190-199.
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Bongki Kim, Jeremy Roy, Winnie W.C. Shum, Nicolas Da Silva & Sylvie Breton. (2015) Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis1. Biology of Reproduction 92:1.
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Ki-Ho Lee. (2014) Expressional Modulation of Connexin Isoforms in the Initial Segment of Male Rat treated with Estradiol Benzoate or Flutamide. Development & Reproduciton 18:4, pages 293-300.
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Julie Dufresne & Daniel G. Cyr. (2014) Regulation of the Pannexin-1 Promoter in the Rat Epididymis1. Biology of Reproduction 91:6.
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A. Feswick, J.S. Ings, M.A. Doyle, T. Bosker, K.R. Munkittrick & C.J. Martyniuk. (2014) Transcriptomics profiling and steroid production in mummichog (Fundulus heteroclitus) testes after treatment with 5α-dihydrotestosterone. General and Comparative Endocrinology 203, pages 106-119.
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Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, R'ada Massarwa, Ka Wai Mok, Nan Li, Chris K. C. Wong, Will M. Lee, Scott B. Snapper, Ben-Zion Shilo, Eyal D. Schejter & C. Yan Cheng. (2014) N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier. PLoS Genetics 10:6, pages e1004447.
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Ki-Ho Lee. (2013) Differential Expression of Multiple Connexins in Rat Corpus and Cauda Epididymis at Various Postnatal Stages. Journal of Animal Science and Technology 55:6, pages 521-530.
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Jiali Cai, Chonggang Wang, Lixing Huang, Meng Chen & Zhenghong Zuo. (2013) A Novel Effect of Polychlorinated Biphenyls: Impairment of the Tight Junctions in the Mouse Epididymis. Toxicological Sciences 134:2, pages 382-390.
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Xiang Xiao, Dolores D. Mruk & C. Yan Cheng. (2013) Intercellular adhesion molecules (ICAMs) and spermatogenesis. Human Reproduction Update 19:2, pages 167-186.
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E. Dube, J. Dufresne, P. T. K. Chan & D. G. Cyr. (2012) Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia. Human Reproduction 27:8, pages 2285-2296.
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