Evaluation of bone mineral density and 25-(OH) vitamin D levels in middle-aged and elderly women with recurrent benign paroxysmal positional vertigo

Abstract

Background: Middle-aged and elderly perimenopausal women are prone to developing BPPV without definite cause. Objectives: This study aimed to investigate the correlation between bone mineral density (BMD), 25-(OH) vitamin D, and serum calcium levels in patients with benign paroxysmal positional vertigo (BPPV) in middle-aged and elderly women.

Material and methods: A total of 103 women with two or more recurrent BPPV episodes (group A) and 80 age-matched healthy controls (group B) were recruited. All subjects had BMD and serum 25-(OH) D levels measurements taken, and the results were compared.

Results: BMD was reduced in group A, and the proportion of osteoporosis was higher than in group B (p = .039). The BMD T-score and 25-(OH) vitamin D level were lower in group A than in group B (p = .004 and p < .0001, respectively). In group A, the BMD T-score was lower (p = .017) and serum 25-(OH) vitamin D level was higher (p < .0001) in premenopausal women than in menopausal women.

Conclusions and Significance: Our study found that middle-aged and elderly women with recurrent BPPV, especially postmenopausal women, may present decreased BMD and serum vitamin D levels.

Chinese abstract

背景：中老年近绝经期妇女易发生BPPV而无明确病因。

目的：探讨中老年女性良性阵发性位置性眩晕（BPPV）患者的骨密度（BMD）、25-（OH）维生素D和血清钙水平的相关性。

材料与方法：招集103例复发性BPPV患者（A组）和80例同年龄的健康对照个体（B组）。对所有受试者都进行了骨密度和血清25-（OH）D水平的测量, 并对结果进行了比较。

结果：A组骨密度降低, 骨质疏松比例明显高于B组（p = .039）。A组骨密度 T评分和25-（OH）维生素D水平低于B组（分别地, p =0.004；p <0.0001）。A组近绝经期妇女的骨密度 T评分较绝经期妇女低（p = .017）, 血清25-（OH）维生素D水平较绝经期妇女高（p <0.0001）。

结论与意义：本研究发现中老年复发性BPPV患者, 尤其是绝经后妇女的BMD和血清维生素D水平可能会降低。

Keywords:

• Benign paroxysmal positional vertigo
• middle-aged and elderly women
• bone mineral density
• osteopenia
• osteoporosis
• 25-(OH) vitamin D

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Bengbu City Health Planning Commission Technology Promotion Project under grant 2018-TGXM04; Bengbu Science and Technology Plan Project under grant 20160325; Bengbu Medical Science Natural Science Foundation Key Project under grant BYKY18166; People's Liberation Army Logistics Support Department Health Care Project under grant 16BJZ18.