Survival study in early stages of glottis cancer, stratified by treatment

Abstract

Introduction

Squamous cell carcinoma (SCC) of the vocal cord in stages I or II can be treated with radiotherapy (RT) or transoral CO₂ laser microsurgery (TLM), with good oncological results.

Objectives

To study the survival of patients with SCC of the vocal cord in early stages, treated with RT or TLM, in a tertiary hospital.

Material and methods

Disease-free survival (DFS), specific survival (SS), and overall survival (OS) were studied in patients diagnosed with stage I and II SCC of the vocal cord, for a span of 10 years of follow-up, based on sociodemographic characteristics of the patient and the primary treatment (TLM or RT).

Results

Both treatments achieved good survival rates. However, long-term SS was greater in patients treated with TLM compared to those treated with RT (91.7% vs. 50%, respectively, p = .001). In addition, patients treated with TLM presented a higher OS in the short term than those treated with RT (99.0% vs. 89.1%, respectively. p = .004).

Conclusions and significance

Primary treatment with TLM obtained better results than RT in the survival of patients with SCC of the vocal cord in the early stages.

Chinese Abstract

简介： I 期或 II 期声带鳞状细胞癌 (SCC) 可通过放射治疗 (RT) 或经口 CO2 激光显微手术 (TLM)治疗, 具有良好的肿瘤学效果。

目的：研究在三级医院接受RT 或 TLM的早期声带 SCC 患者的生存情况。

材料和方法：研究了一期和二期声带SCC患者的无病生存期（DFS）、特异生存期（SS）和总生存期（OS）, 就患者的社会人口学特征和主要治疗方法（TLM或 RT）对他们进行了10年之久的随访。

结果：两种治疗均取得了良好的存活率。然而, 与 RT 治疗相比, TLM 治疗的患者的长期 SS 更大（分别为50% 和 91.7%, p = .001）。此外, 接受 TLM 治疗的患者在短期内的 OS 高于接受 RT 治疗的患者（分别为 99.0% 和 89.1%。p = .004）。

结论与意义：对于早期声带鳞状细胞癌患者的生存率, TLM治疗优于RT。

Keywords:

• Squamous cell carcinoma
• vocal cord
• transoral laser microsurgery
• survival

Disclosure statement

No potential conflict of interest was reported by the authors.