Change in HbA_1c concentration as decision parameter for frequency of HbA_1c measurement

Abstract

Hemoglobin A_1c (HbA_1c) is a long-term measure for glucose concentration in plasma. Since its introduction as a diabetes monitoring tool, and its more recent application as a diagnostic tool, the number of measurements of HbA_1c have risen dramatically. However, HbA_1c change is slow, so repeating measurements should not be done too often. We use a large, unfiltered dataset from 52,017 patients to determine the possible rate of change in HbA_1c concentration. In our laboratory, the critical difference between HbA_1c measurements is 8.5%. Our data show that a 1-unit HbA_1c rise takes 4 weeks to occur, hence, at a HbA_1c concentration around 50 mmol/mol Hgb, a critically increased HbA_1c concentration cannot be determined until after 16 weeks. Conversely a critically lower HbA1c can manifest itself after 2 weeks, but after 7 weeks the dropping tendency stops. The amount of measurements that can be cancelled because they were taken sooner than 16 weeks is 23 percent.

Keywords:

• Glycated Hemoglobin A
• clinical laboratory information systems
• clinical chemistry tests
• economics
• medical

Disclosure statement

No potential conflict of interest was reported by the authors.