Feasible selective synthesis of 3-Acetylindoles and 3-Acetoacetylindoles from β-ethylthio-β-indoly α, β-unsaturated ketones

Abstract

An efficient and selective synthesis of 3-acetyl free(N-H)/N-substituded indoles and 3-acetoacetyl free(N-H)/N-substituded indoles has been developed via the hydrolysis reaction of β-ethylthio-β-indoly α, β-unsaturated ketones in the presence of 3 equivalent of NaOH and 5 mol% of H₂SO₄, respectively. The procedure features easy operation, excellent yields, and high selectivity, compatibility and practicability.

Graphical Abstract

Keywords:

• 3-acetylindole
• 3-acetoacetylindole
• β-ethylthio- β -indoly α
• β-unsaturated ketone
• selectivity
• acetylation

Additional information

Funding

Supported by the Foundation of Jilin Province Education Administration [2016037].