Abstract
An efficient, simple, and environmentally friendly synthesis of a series of chromeno[2,3-d]pyrimidine-trione derivatives has been accomplished via the three-component reaction of a barbituric acid, dimedone/cyclohexane-1,3-dione, and aromatic aldehydes using Sc(OTf)3 as a recyclable catalyst under solvent-free condition. This method exploits the use of Sc(OTf)3 as a Lewis acid catalyst in organic synthesis and offers many rewards such as excellent product yield and easy work-up procedure. Harmless reaction conditions, as well as the absence of side-products, are another green aspects of this protocol.
GRAPHICAL ABSTRACT
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Acknowledgement
The authors acknowledge CIF, IIT (BHU) for instrumentation facilities.