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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 9
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Articles

Efficient and stereoselective synthesis of thiosulfinates from disulfide using cumene hydroperoxide in the presence of titanium-based catalyst systems

Pengju SunXiangya School of Pharmaceutical Sciences, Central South University, Changsha, China; View further author information
,
Jiansheng HuangDrug Research Institute, Hisun Group, Taizhou, ChinaView further author information
,
Jinyi XuDrug Research Institute, Hisun Group, Taizhou, ChinaView further author information
&
Niefang YuXiangya School of Pharmaceutical Sciences, Central South University, Changsha, China; ;Drug Research Institute, Hisun Group, Taizhou, ChinaCorrespondence[email protected]
View further author information
Pages 1165-1172 | Received 19 Jan 2019, Published online: 02 Apr 2019
 
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Abstract

An efficient and stereoselective procedure of oxidizing disulfide to thiosulfinate 2a using CHP as the oxidant and economically available Ti(O-i-Pr)4/L-DET/H2O as catalysts were developed. The reaction went smoothly under mild conditions with synthetic useful yield and the workup for obtaining the final product is quite convenient.

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Additional information

Funding

We are grateful to the National Natural Science Foundation of China [Project Number: 81172927 and 81573297] and the R&D Center of Hisun Group for the support of this work.

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