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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 13
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Articles

A novel and efficient asymmetric synthesis of anti-HIV drug maraviroc

Yijun ZhuChangzhou Pharmaceutical Factory, Changzhou, China; View further author information
,
Hongyan LiState Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Key Laboratory of Anti-Infectives, State Institute of Pharmaceutical Industry, Shanghai, ChinaView further author information
,
Kuaile LinState Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Key Laboratory of Anti-Infectives, State Institute of Pharmaceutical Industry, Shanghai, ChinaView further author information
,
Bing WangChangzhou Pharmaceutical Factory, Changzhou, China; View further author information
&
Weicheng ZhouState Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Key Laboratory of Anti-Infectives, State Institute of Pharmaceutical Industry, Shanghai, ChinaCorrespondence[email protected]
View further author information
Pages 1721-1728 | Received 01 Feb 2019, Published online: 03 May 2019
 
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Abstract

A novel and efficient route to asymmetric synthesis of Maraviroc by using (S)-tert-butanesulfinamide as chiral auxiliary is described. Two interesting impurities of the process are isolated and identified. The synthesis was concise, mild, and easy to operate. The overall yield and stereoselectivity were excellent.

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Additional information

Funding

This work was funded by the Jiangsu Province "innovation and entrepreneurship program" in 2017 & 2018 and Jiangsu Planned Projects for Postdoctoral Research Funds [2018K264C].

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