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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 18
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Articles

Efficient synthesis and anti-bovine viral diarrhea virus evaluation of 5-(aryldiazo)salicylaldehyde thiosemicarbazone derivatives

Samir Y. AbbasOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; Correspondence[email protected]
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,
Wahid M. BasyouniOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; Correspondence[email protected]
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,
Khairy A. M. El-BayoukiOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; View further author information
,
Reham M. DawoodMicrobial Biotechnology Department, National Research Centre, Cairo, EgyptView further author information
,
Tawfeek H. AbdelhafezMicrobial Biotechnology Department, National Research Centre, Cairo, EgyptView further author information
&
Mostafa K. ElawadyMicrobial Biotechnology Department, National Research Centre, Cairo, EgyptView further author information
Pages 2411-2416 | Received 17 Apr 2019, Published online: 28 Jun 2019
 
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Abstract

An efficient procedure for the synthesis of 5-(aryldiazo)salicylaldehyde thiosemicarbazone derivatives 1-25 was achieved via the condensation of 5-(aryldiazo)salicylaldehyde derivatives I–V with N-(4)-substituted thiosemicarbazide derivatives. Antiviral activity of the synthesized compounds was carried out. From the obtained results, it was noticed that compound 11 has a strong antiviral activity.

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Funding

Financial support was provided by the Science and Technology Development Fund in Egypt (STDF) through the project No. 14993.

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