Abstract
A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C−N and S−N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol.
Graphical Abstract
Acknowledgments
We are thankful to the NMR facility, Institute of Excellence, University of Mysore, Manasagangotri, Mysore, India for spectral data.