A practical total synthesis of wedelolactone

Abstract

Wedelolactone, a benzofuran based natural product that can be isolated from Eclipta prostrata, exhibits a variety of biological activities. It is inefficient to obtain wedelolactone from natural sources, so it is of great significance to perform total synthesis study on this important compound. In the current study, a novel total synthesis of wedelolactone featuring palladium-catalyzed Suzuki coupling and acid-promoted intramolecular transesterification was discovered. In comparison with those reported total synthesis routes, the current strategy is more convenient and efficient, and can be used as a potential route for large scale production.

Graphical Abstract

Keywords:

• Natural product
• Suzuki coupling
• synthesis
• wedelolactone

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China [81960623], the Natural Science Foundation of Ningxia Province [2022AAC03249], the Graduate Student Innovation Project of North Minzu University [YCX22153].