Copper catalyzed N-arylation of sulfonamides with aryl bromides under ligand-free conditions

Abstract

A practical strategy for the C-N cross-coupling of both aliphatic and aromatic sulfonamides with a variety of substituted aryl bromides is reported. Under the optimized conditions, a good representative of N-arylated products were obtained in good to excellent yields (up to 78%) under the ligand-free conditions.

Graphical Abstract

Keywords:

• Aryl bromides
• copper (I) iodide
• ligand-free
• N-arylation
• sulfonamides

Acknowledgement

We would like to thank the National Institute of Education (RI 2/21 TYC), Nanyang Technological University for their generous financial support.