Cobalt^II phthalocyanine catalyzed efficient synthesis of substituted 1-phenyl-1-propanone from ketones with primary alcohols (α-alkylation)

Abstract

Herein, we report the cobalt(II) phthalocyanine catalyzed one-pot α-alkylation reaction of ketones with primary alcohols to provide the substituted 1-phenyl-1-propanone as the desired compound. We have utilized different electron-rich and electron-deficient substituted alcohols and substituted acetophenones as the substrates for the present catalytic system. The reaction proceeds well with electron-deficient and electron-rich substrates and provide good to excellent yield of products. The products are characterized and confirmed by ¹H NMR, ¹³C NMR, and elemental analysis techniques and the data are supported with literature values.

Graphical Abstract

Keywords:

• Substituted benzyl alcohols
• substituted acetophenones
• cobalt(II) phthalocyanine
• one-pot reaction
• α-alkylation
• recyclability

Data availability statement

Experimental procedure and complete characterization data (m.p., ¹HNMR and ¹³CNMR, and spectra) of all compounds are afforded in the supporting information.

Acknowledgments

The authors are thankful to University of Delhi, India.

Additional information

Funding

This research work is financially supported by UGC-BSR fellowship to Prof. S. M. S. Chauhan and student fellowship to Anshu Dandia by UGC.