Synthetic Approaches and Biological Applications of Aminopyrazolecarbonitriles

Abstract

We have framed a detailed account of the synthetic methods and the bioactivity and pharmacological aspects available for aminopyrazolecarbonitriles as they have substantial role as a building block and starting materials for producing enormous biologically active heterocyclic skeletons. Hydrazine derivatives are important precursors in the synthesis of aminopyrazolecarbonitriles where, the nucleophilic addition of hyrazines to monocyano, dicyano, tricyano and tetracyanoethylenes led to the formation of the target compounds via the formation of two C–N bonds. Multicomponent reactions (MCRs) of hydrazines, aromatic aldehydes, and malononitrile is considered an efficient one pot protocol for the synthesis of aminopyrazolecarbonitriles. Intramolecular cyclization involves one bond formation and functional group transformations are used to prepare aminopyrazolecarbonitriles.

Graphical Abstract

Keywords:

• Aminopyrazolecarbonitriles
• biological applications
• heterocyclization
• synthesis