Progress of oxidative stress in endometrium decidualization

Abstract

The difficulty in maintaining the balance between oxides and antioxidants causes a phenomenon named oxidative stress. Oxidative stress often leads to tissue damage and participates in the pathogenesis of a series of diseases. Decidua provides the ‘soil’ for embryo implantation, and the normal decidualization shows the characteristics of strong antioxidation. Once the mechanism of antioxidant stress goes awry, it will lead to a series of pregnancy-related diseases. In recent years, more and more studies have shown that oxidative stress is involved in pregnancy-related diseases caused by abnormal decidualization of the endometrium. In order to have a more comprehensive understanding of the role of oxidative stress in decidual defect diseases, this paper reviews the common decidual defect diseases in conjunction with relevant regulatory molecules, in order to arouse thinking about the importance of oxidative stress, and to provide more theoretical basis for the aetiology of decidual defects.

Graphical Abstract

Keywords:

• Oxidative stress
• abortion
• pre-eclampsia
• implantation
• decidualization

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

No specific data has been generated for this review paper and accordingly no data access is required.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [81960279], Innovation Fund for Colleges and Universities of Gansu Province [2020B-014], Health industry Scientific Research Program of Gansu Province [GSWSKY2021-012], Natural Science Foundation of Gansu Province [21JR7RA366], Fund of the First Hospital of Lanzhou University [ldyyyn2021-29, ldyyyn2019-55], Project of Science and Technology Department of Gansu Province [21JR1RA078].