Diagnostic value of non-coding RNAs in ovarian cancer

Abstract

The type of primary tumour of the ovary ranks first among all organs in the body. Although the incidence of malignant ovarian tumour ranks third among gynaecological malignancies, it is the most fatal type. A lack of effective diagnostic methods for early ovarian cancer remains, and the efficacy of advanced ovarian cancer is often unsatisfactory; the five-year survival rate of stage III–IV is less than 30%. Non-coding RNA is RNA that does not have protein-coding potential and was once considered as ‘junk DNA’. However, increasing number of studies have shown that the disorder of non-coding RNA is related to a variety of diseases, including the occurrence and development of tumours. We summarised the dysregulated non-coding RNAs (miRNAs, circRNAs, and lncRNAs) reported currently in ovarian cancer and their functional mechanisms, and the clinical value of different types of ncRNAs as diagnostic or predictive markers for ovarian cancer, providing further evidence for non-coding RNAs to be considered as biomarkers of ovarian cancer.

Keywords:

• MicroRNA
• lncRNA
• circRNA
• biomarker
• ovarian cancer

Acknowledgements

The authors thank Editage (www.editage.cn) for English language editing.

Ethics approval and consent to participate

Not applicable.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Datasets are available through the corresponding author upon reasonable request.