Petroclival tension pneumocephalus: an unrivalled life threatening complication linked to molecular-targeted therapy

Abstract

A 73-year-old man with a petroclival tumor (metastatic renal cell carcinoma) presented with a progressive consciousness disturbance attributed to tension pneumocephalus during molecular-targeted therapy following low-dose fractionated radiotherapy for a petroclival tumor. The skull base defect was successfully reconstructed vi an endoscopic endonasal approach.

Keywords:

• Tension pneumocephalus
• molecular-targeted therapy
• petroclival tumor
• radiotherapy
• oncology team

Disclosure statement

The authors declare no financial support or industry affiliation. The authors have registered the COI Disclosure Statement Forms for The Japan Neurosurgical Society.