Design and Optimization of PLGA Particles to Deliver Immunomodulatory Drugs for the Prevention of Skin Allograft Rejection

ABSTRACT

Background: Recent advancements in therapeutic strategies have attracted considerable attention to control the acute organs and tissues rejection, which is the main cause of mortality in transplant recipients. The long-term usage of immunosuppressive drugs compromises the body immunity against simple infections and decrease the patients’ quality of life. Tolerance of allograft in recipients without harming the rest of host immune system is the basic idea to develop the therapeutic approaches after induction of donor-specific transplant.

Methods: Controlled and targeted delivery system by using biomimetic micro and nanoparticles as carriers is an effective strategy to deplete the immune cells in response to allograft in an antigen-specific manner. Polylactic-co-glycolic acid (PLGA) is a biocompatible and biodegradable polymer, which has frequently being used as drug delivery vehicle.

Results: This review focuses on the biomedical applications of PLGA based biomimetic micro and nano-sized particles in drug delivery systems to prolong the survival of alloskin graft.

Conclusion: We will discuss the mediating factors for rejection of alloskin graft, selective depletion of immune cells, controlled release mechanism, physiochemical properties, size-based body distribution of PLGA particles and their effect on overall host immune system.

KEYWORDS:

• Acute rejection
• allograft
• biomimetic
• PLGA
• targeted delivery

Acknowledgments

The authors are thankful to the Science and Technology Support Program of Jiangsu Province [BE2017714], National Natural Science Foundation of China [81172823, 81372448] and Fundamental Research Funds for the Central Universities of China and Postgraduate Research and Practice Innovation Program of Jiangsu Province [KYCX17-0164] to provide the financial support to complete the research related to this review article.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [81172823, 81372448]; Postgraduate Research and Practice Innovation Program of Jiangsu Province [KYCX17-0164];Science and Technology Support Program of Jiangsu Province [BE2017714].