The Relationship between Fluorescein Angiography Leakage after Infliximab Therapy and Relapse of Ocular Inflammatory Attacks in Ocular Behçet’s Disease Patients

ABSTRACT

Purpose: To clarify the relationship between fluorescein angiography (FA) leakage after infliximab therapy and ocular attack relapse in patients with ocular Behçet’s disease (BD).

Methods: Patients with ocular BD were divided into two groups based on the presence (Group 1) or absence (Group 2) of ocular attacks after IFX therapy. FA leakage was evaluated by FA score in each of the optic discs, macula, large retinal vessels, and capillary vessels. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the relationship between FA score after IFX therapy and ocular attack relapse.

Results: The areas under the curves obtained from the ROC curve of optic disc score and capillary vessels score after IFX therapy were 0.867 (95% confidence interval [CI]: 0.788–0.946) and 0.788 (95% CI: 0.649–0.927), respectively.

Conclusions: FA leakage in the optic disc and capillary vessels after IFX therapy was strongly related to ocular attack relapse.

Keywords:

• Capillary vessels
• fluorescein angiography
• infliximab therapy
• ocular Behçet’s disease
• optic disc

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was supported in part by a Grant-in-Aid for JSPS KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Grant Number JP18K09398) and a Grant-in-Aid for Research on Specific Diseases of the Health Sciences Research from the Ministry of Health, Labor and Welfare of Japan (Grant Number H29-nanti-ippan-050).