Endogenous Bacterial Endophthalmitis: A Five-Year Retrospective Review at a Tertiary Care Academic Center

ABSTRACT

Purpose

To better characterize the demographics and outcomes of endogenous bacterial endophthalmitis (EBE).

Methods

Retrospective observational case series of 49 eyes of 41 patients with EBE evaluated at a single academic center.

Results

Gram stain (p = .395), symptom duration prior to treatment (p = .483), and number of intravitreal antimicrobial injections (p = .421) did not correlate with mean change in VA. There was no significant difference between mean LogMAR VA at initial evaluation (1.7 ± 0.9) and last available follow up (1.4 ± 1.1, p = .15). Patients with bilateral EBE had 7.25 times greater odds of having cancer (95% CI 1.28, 41.14; p = .025).

Conclusion

EBE in a North American population showed poor visual recovery despite treatment. It was most commonly due to gram-positive bacteria with the most common infectious source being endocarditis. Malignancy should be considered in patients with bilateral EBE.

Keywords:

• Endogenous
• endogenous bacterial endophthalmitis
• endophthalmitis
• North America
• bacterial endophthalmitis

Declaration of interest

No conflicting relationships, competing interests or funding in relation to this study exist for any author.