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Ocular Immunology and Inflammation Volume 28, 2020 - Issue sup1: COTS supplement
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Invited Review

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Ilaria Testi1 Moorfields Eye Hospital, NHS Foundation Trust, London, UKView further author information
, MD,
Rupesh Agrawal2 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;3 School of Material Science and Engineering, Nanyang Technological University, Singapore, Singapore;4 Singapore Eye Research Institute, Singapore, SingaporeORCID Iconhttps://orcid.org/0000-0002-6662-5850View further author information
, MD, FRCS,ORCID Icon,
Sarakshi Mahajan5 Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
, MBBS,
Aniruddha Agarwal6 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0003-4985-9855View further author information
, MSORCID Icon,
Dinesh Visva Gunasekeran2 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;3 School of Material Science and Engineering, Nanyang Technological University, Singapore, SingaporeView further author information
, MBBS,
Dhananjay Raje7 MDS Bioanalytics, Nagpur, IndiaView further author information
, PhD,
Kanika Aggarwal6 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaView further author information
, MS,
Somasheila I. Murthy8 Tej Kohli Cornea Institute, LV Prasad Eye Institute, Hyderabad, IndiaView further author information
, DNB,
Mark Westcott1 Moorfields Eye Hospital, NHS Foundation Trust, London, UKView further author information
, FRCOphth,
Soon Phaik Chee4 Singapore Eye Research Institute, Singapore, Singapore;9 Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeORCID Iconhttps://orcid.org/0000-0002-6308-5721View further author information
, FRCSEdORCID Icon,
Peter McCluskey10 Department of Clinical Ophthalmology & Eye Health, Central Clinical School, Save Sight Institute, The University of Sydney, Sydney, AustraliaView further author information
, MD,
Su Ling Ho2 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, SingaporeView further author information
, FRCSGlasg,
Stephen Teoh2 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, SingaporeView further author information
, FRCSEd,
Luca Cimino11 Ocular Immunology Unit, Azienda USL IRCCS, Reggio Emilia, ItalyORCID Iconhttps://orcid.org/0000-0001-7956-9950View further author information
, MDORCID Icon,
Jyotirmay Biswas12 Department of Ophthalmology, Sankara Nethralaya, Chennai, IndiaView further author information
, MS,
Shishir Narain13 Department of Ophthalmology, Shroff Eye Centre, New Delhi, IndiaView further author information
, MD,
Manisha Agarwal14 Department of Ophthalmology, Dr Shroff’s Charity Eye Hospital Daryaganj, New Delhi, IndiaView further author information
, MS,
Padmamalini Mahendradas15 Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, IndiaView further author information
, DNB,
Moncef Khairallah16 Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, TunisiaView further author information
, MD,
Nicholas Jones17 Department of Ophthalmology, University of Manchester, Manchester, UKView further author information
, FRCSOphth,
Ilknur Tugal-Tutkun18 Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Instanbul, TurkeyORCID Iconhttps://orcid.org/0000-0002-4020-453XView further author information
, MDORCID Icon,
Kalpana Babu19 Prabha Eye Clinic & Research Centre, Vittala International Institute of Ophthalmology, Bangalore, IndiaView further author information
, DNB,
Soumayava Basu20 Department of Ophthalmology, LV Prasad Eye Institute, Bhubaneswar, IndiaView further author information
, MS,
Ester Carreño21 Departamento de Oftalmología, Hospital Universitario Fundacion Jimenez Diaz, Madrid, SpainView further author information
, MD,
Richard Lee22 Department of Ophthalmology, Bristol Eye Hospital, Bristol, UKView further author information
, PhD,
Hassan Al-Dhibi23 Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi ArabiaView further author information
, MD,
Bahram Bodaghi24 DHU SightRestore, Department of Ophthalmology, Sorbonne University, Paris, FranceView further author information
, MD,
Alessandro Invernizzi25 Eye Clinic, Department of Biomedical and Clinical Science “L. Sacco”, Luigi Sacco Hospital, University of Milan, Milan, ItalyORCID Iconhttps://orcid.org/0000-0003-3400-1987View further author information
, MDORCID Icon,
Debra A. Goldstein26 Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, IL, USAView further author information
, MD,
Carl P. Herbort27 Centre for Ophthalmic Specialised Care, University of Lausanne, Lausanne, SwitzerlandView further author information
, MD,
Talin Barisani-Asenbauer28 The Centre for Ocular Inflammation and Infection (OCUVAC), Laura Bassi Centre of Expertise Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, AustriaView further author information
, PhD,
Julio J. González-López29 Department of Ophthalmology, Ramón y Cajal University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0001-7210-7809View further author information
, PhDORCID Icon,
Sofia Androudi30 Department of Ophthalmology, University of Thessaly, Larissa, GreeceORCID Iconhttps://orcid.org/0000-0002-5303-7793View further author information
, MDORCID Icon,
Reema Bansal6 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaView further author information
, MS,
Bruttendu Moharana6 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaView further author information
, MS,
Simona Degli Esposti3 School of Material Science and Engineering, Nanyang Technological University, Singapore, SingaporeView further author information
, MD,
Anastasia Tasiopoulou1 Moorfields Eye Hospital, NHS Foundation Trust, London, UKView further author information
, MD,
Sengal Nadarajah1 Moorfields Eye Hospital, NHS Foundation Trust, London, UKView further author information
, MD,
Mamta Agarwal12 Department of Ophthalmology, Sankara Nethralaya, Chennai, IndiaView further author information
, DNB,
Sharanya Abraham12 Department of Ophthalmology, Sankara Nethralaya, Chennai, IndiaView further author information
, MD,
Ruchi Vala15 Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, IndiaView further author information
, MD,
Ramandeep Singh6 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaView further author information
, MS,
Aman Sharma31 Department of Rheumatology, PGIMER, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0003-0813-1243View further author information
, MDORCID Icon,
Kusum Sharma32 Department of Microbiology, PGIMER, Chandigarh, IndiaView further author information
, PhD,
Manfred Zierhut33 Centre of Ophthalmology, Department of Ophthalmology, University of Tuebingen, Tuebingen, GermanyView further author information
, PhD,
Andres Rousselot34 Department of Ophthalmology, Universidad del Salvador of Buenos Aires, Buenos Aires, ArgentinaView further author information
, MD,
Robert Grant35 Faculty of Health, Social Care and Education, Kingston University and St George’s, University of London, London, UKView further author information
, MD,
Onn Min Kon36 Chest and Allergy Clinic, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UKView further author information
, MRCP,
Emmett T. Cunningham37 The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, California, USAView further author information
, PhD,
John Kempen38 Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA;39 MCM Eye Unit, MyungSung Christian Medical Center and MyungSung Medical School, Addis Ababa, EthiopiaView further author information
, PhD,
Quan Dong Nguyen5 Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
, PhD,
Carlos Pavesio1 Moorfields Eye Hospital, NHS Foundation Trust, London, UKView further author information
, FRCSOpth &
Vishali Gupta6 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaCorrespondence[email protected]
View further author information
, MS show all
Pages 8-16 | Received 23 Feb 2019, Accepted 16 Jul 2019, Published online: 25 Nov 2019
 
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1

ABSTRACT

Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

Declaration of interest

There is no conflict of interest for any authors.

Additional information

Funding

The research was partially funded by the National Institute for Health Research (NIHR) Biomedical Research Center at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology.

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