Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease

ABSTRACT

Purpose: To evaluate the prognostic value of OCT in acute VKH disease

Methods: Retrospective series of consecutive VKH patients seen with the first presentation, a minimum follow-up of 1 year and serial OCT imaging. The primary outcome was the clinical activity phase at 1, 2 and 3 years.

Results: Among 29 subjects, 7 resolved, 17 became chronic, and 5 developed chronic recurrent VKH. Median RNFL measurement obtained 2 months post-treatment was higher among subjects who developed chronic VKH (p-value = 0.03) and chronic recurrent disease (p-value = 0.04). Median CRT 1-week post-treatment was lower among subjects who developed PPA (p-value = 0.03). CRT 2 months post-treatment was higher among subjects who developed vitiligo (p-value = 0.02).

Conclusion: OCT is helpful in early recognition of the predominantly optic disc swelling variant which carries a poorer prognosis. Lower CRT reading at 1 week and persistently raised CRT at 2 months post-treatment correlated with chronic recurrent disease.

Keywords:

• Choroidal inflammation
• immunosuppression
• inflammation
• non-infectious chorioretinopathies
• Panuveitis

Acknowledgments

Presented at Global Ocular Inflammation Workshops, 10th Workshop on Vogt Koyanagi Harada disease and Sympathic Ophthalmia, Bali, Indonesia 27–29 April 2017.

Disclosure of interest

The authors report no conflict of interest and no source of financial grants and other funding.