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Ocular Immunology and Inflammation Volume 29, 2021 - Issue 2
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Original Articles

Association of a CARD9 Gene Haplotype with Behcet’s Disease in a Chinese Han Population

Fuzhen Li1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. ChinaView further author information
, MD, PhD,
Liying Shi1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. China;2 The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, P.R. ChinaView further author information
, MD,
Liping Du1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. ChinaView further author information
, MD, PhD,
Na Li1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. ChinaView further author information
, BS,
Qingfeng Cao3 The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P.R. ChinaView further author information
, MS,
Xin Ma1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. China;2 The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, P.R. ChinaView further author information
, MD,
Tingting Pang1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. China;2 The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, P.R. ChinaView further author information
, MD,
Yizong Liu1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. China;2 The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, P.R. ChinaView further author information
, MD,
Aize Kijlstra4 University Eye Clinic Maastricht, Maastricht, The NetherlandsView further author information
, PhD,
Guangming Wan1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. ChinaView further author information
, MD, PhD &
Peizeng Yang1 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. China;3 The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P.R. ChinaCorrespondence[email protected]
View further author information
, MD, PhD show all
Pages 219-227 | Received 24 Jan 2019, Accepted 04 Oct 2019, Published online: 31 Oct 2019
 
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ABSTRACT

Purpose: To investigate the association of CARD9 gene polymorphisms with Behcet’s disease (BD) and acute anterior uveitis (AAU) in a Chinese Han population.

Methods: We performed a case-control association study in 480 patients with BD, 1151 patients with AAU and 1440 healthy controls. Six single nucleotide polymorphisms (SNPs) of CARD9 were genotyped, including rs4077515, rs11145769, rs59902911, rs9411205, rs4073153 and rs1135314.

Results: None of the individual SNPs in the CARD9 gene showed an association with either BD or AAU. Haplotype analysis revealed a significant decrease of the frequency of a CARD9 gene haplotype CGCCA (rs4077515, rs11145769, rs59902911, rs9411205, rs4073153) in BD when compared to healthy controls (Pc = 0.012, OR = 0.585, 95%CI = 0.409 ~ 0.837). Haplotype analysis did not show an association between CARD9 and AAU.

Conclusions: This study shows that a five-SNP haplotype of the CARD9 gene (CGCCA) may be a protective factor for BD with ocular involvement, but not for AAU.

ACKNOWLEDGMENTS

We thank all participants for their contribution to the present study.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

SUPPLEMENTARY MATERIAL

Supplemental data for this article can be accessed on the publisher’s website.

Additional information

Funding

This work was supported by “51282” Project for Henan Medical Science and Technology Innovative Talents; Joint Funds of the National Natural Science Foundation of China [U1304812]; Medical Scientific and Technological Project of Henan Province [201602092]; Scientific and Technological Project of Henan Province [172102310374]; Natural Science Foundation Major International (Regional) Joint Research Project [81720108009]; and National Natural Science Foundation Project of China [81770914].

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