Association of Killer Cell Immunoglobulin-like Receptor Genotypes and Haplotypes in Dry Eye Disease Patients Treated with Restasis and Systane

ABSTRACT

Purpose: whether the Killer immunoglobulin-like receptor (KIR) genotypes and haplotypes are associated with the improvement in dry eye disease (DED) patients treated with Restasis and Systane (RS) remain unclear.

Methods: Polymerase chain reaction with sequence-specific primers (PCR-SSP) was used to analyze KIR genes in a Chinese Han population of 198 severe DED patients treated with RS.

Results: The higher frequencies of KIR genotype M, AF, AJ and haplotype 2 and 8 (P = .001, P = .03, P = .004, P = .000 and P = .023, respectively) and the lower frequencies of genotype AG and haplotype 1 (P = .000 and P = .000, respectively) were observed in complete responders (CR) than those in null or partial responders (NPR) of DED patients treated by RS.

Conclusions: The patients with KIR genotype M, AF and AJ might be of advantage to therapy with RS, which are useful for improving novel personalized precise therapy strategy in DED patients.

KEYWORDS:

• Killer cell immunoglobulin-like receptor
• genotype
• haplotype
• dry eye disease restasis
• systane

Author contributions

Study design (GFR, YLZ); data collection (GFR, LZ, YLZ, YXL, JH, HW, QW); analysis and interpretation of data (GFR, LZ, YLZ); writing the manuscript (GFR, LZ, YLZ); statistical expertise (GFR, LZ, YLZ).

Declaration of interest

The authors declare no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was supported by Natural Science Foundation of Shandong Province (ZR2017MH070, ZR2015HM027), Shandong Province Young and Middle-Aged Scientists Research Awards Fund (BS2011SW044), Medicine and Health Science and Technology Development Planning Projects of Shandong Province (2013WS0170).