TWEAK and monocyte to HDL ratio as a predictor of metabolic syndrome in patients with polycystic ovary syndrome

Abstract

We aimed at analyzing serum TWEAK levels and monocyte/HDL ratio in polycystic ovary syndrome (PCOS) and their predictivity for metabolic syndrome (MS) in PCOS. We included 71 women with PCOS and 40 healthy controls without any cardiovascular risk factors in this cross-sectional study. Patient group was classified as MS positive (n = 34) and negative (n = 37). Study group had higher monocyte/HDL ratio and TWEAK levels (9.59 ± 2.82 vs 8.2 ± 2.46, p = .007 and 1085.54 ± 780.95 vs 694.88 ± 369.67 ng/ml, p = .009). Monocyte/HDL ratio and TWEAK levels were higher in MS positive group (10.47 ± 2.81 vs 8.77 ± 2.61, p = .01 and 1417.59 ± 921.52 vs 780.41 ± 455.67, p = .009). In multivariate regression analysis, monocyte/HDL ratio (>9.9, OR 3.42, 95%CI 1.41–5.78, p = .008) and TWEAK (>846.5 ng/ml, OR 5.49, 95%CI 3.14–7.59, p = .002) were found to be independent predictors of MS in study group. Discriminative value of monocyte/HDL ratio for MS in study group was evaluated by receiver operating curve. Area under curve for monocyte/HDL ratio was 0.669 with a sensitivity of 70.3% and specifity of 67.7%, cutoff value was >9.9. Receiver operating curve for TWEAK at >846.5 pg/ml threshold to diagnose MS in study group was performed and area under the curve was 0.769 with a sensitivity of 73% and specifity of 72%. TWEAK and monocyte/HDL ratio may be promising in predicting MS at early stages in PCOS to prevent future cardiovascular diseases by modifying life-style or giving pharmacotheraphy.

摘要

我们旨在分析多囊卵巢综合征（PCOS）血清TWEAK水平和单核细胞/HDL比值及他们对PCOS患者发生代谢综合征（MS）的预测价值。此横断面研究招募了71名PCOS女性和40名无任何心血管风险因素的健康对照女性。患者组被分为MS阳性（n=34）和阴性（n=37）。研究组单核细胞/HDL比值和TWEAK水平较高（9.59 ± 2.82 vs 8.2 ± 2.46, p = .007 and 1085.54 ± 780.95 vs 694.88 ± 369.67 ng/ml, p = .009）。单核细胞/HDL比值和TWEAK水平在MS阳性组较高（10.47 ± 2.81 vs 8.77 ± 2.61, p = .01 and 1417.59 ± 921.52 vs 780.41 ± 455.67, p = .009）。多元回归分析发现, 研究组中单核细胞/HDL比值（>9.9, OR 3.42, 95%CI 1.41–5.78, p = .008）和TWEAK（>846.5 ng/ml, OR 5.49, 95%CI 3.14–7.59, p = .002）是MS的独立预测因子。受试者工作曲线评估研究组单核细胞/HDL比值对MS的鉴别价值。单核细胞/HDL比值的曲线下面积是0.669, 灵敏度70.3%, 特异度67.6%, 截断值为 >9.9。受试者工作曲线示研究组中TWEAK阈值>846.5 pg/m以诊断MS, 曲线下面积为0.769, 灵敏度73%, 特异度72%。TWEAK和单核细胞/HDL比值可用于预测PCOS早期的代谢综合征, 通过改变生活方式或进行药物治疗, 以预防未来的心血管疾病。

Keywords:

• Monocyte to HDL cholesterol ratio
• metabolic syndrome
• polycystic ovary syndrome
• TWEAK

Disclosure statement

No potential conflict of interest was reported by the authors.