The impact of circulating 25-hydroxyvitamin and oral cholecalciferol treatment on menstrual pain in dysmenorrheic patients

Abstract

This study aims to determine Vitamin-D level in patients with primary dysmenorrhea and investigate the effect of Vitamin-D replacement on symptoms. About 100 patients in the 18–30 age group followed-up with primary dysmenorrhea diagnosis were included in this observational study. The pain severity was assessed using the visual analog scale (VAS). 25-hydroxy vitamin D(25(OH)D) levels of the patients were measured and the replacement therapy was applied according to measurement results. The patients were followed for three months in total. At the end of the three-month period, the 25(OH)D level was measured and the VAS score was assessed once more after the therapy. 25(OH)D level was insufficient in 23.0%, deficient in 45.0%, and severely deficient in 32.0% of the patients. It was found that the VAS score increased as the 25(OH)D level decreased (r = −0.320; p = .002). A significant reduction was observed in VAS scores after Vitamin-D treatment in all three groups; the amount of reduction in VAS score was determined to be higher in the patients with severely deficient levels of 25(OH)D, compared to the patients with deficient or insufficient levels (p < .001). A significant and negative correlation was found between Vitamin-D and symptoms associated with dysmenorrhea in our study. The Vitamin-D replacement therapy led to a significant decrease in symptoms.

摘要

本研究旨在探究原发性痛经患者维生素D水平和探究维他命D对症状改善作用的影响。在这项观察性研究中, 纳入了100例18-30岁被诊断为原发性痛经的患者。疼痛的严重程度采用视觉模拟评分（VAS）。检测患者体内25-羟基维生素D3水平并且根据检测结果进行替代治疗。这些患者总共随访3个月。3个月治疗结束后检测体内 25(OH)D的水平并且再次评估VAS评分。25(OH)D不足组有23%, 缺乏组占45%, 严重不足组占32%。VAS评分随着25(OH)D水平的下降而升高(r = -0.320; p=.002)。经过维生素D治疗后的三组, VAS评分均显著下降；25(OH)D水平严重不足组的VAS评分下降程度高于25(OH)D水平缺乏或不足组的患者 (p < .001)。我们的研究发现维生素D与痛经相关的症状存在显著的负相关, 维生素D的替代治疗能够使症状明显减轻。

Keywords:

• Primary dysmenorrhea
• PTH
• VAS score
• Vitamin-D

Disclosure statement

No potential conflict of interest was reported by the authors.