Paraoxonase 1 (PON1) Q192R and L55M polymorphisms, lipid profile, lipid peroxidation and lipoprotein-a levels in Turkish patients with pregnancy-related disorders

Abstract

The aim of this study was to investigate the role of PON1Q192R and L55M single nucleotide polymorphisms(SNPs) and its association with the maternal levels of lipid parameters in gestational diabetes mellitus(GDM) and preeclampsia(PE). Ninety-nine pregnant with GDM, 97 pregnant with PE and 98 healthy pregnant were included in the study. No statistically significant difference was observed in the alleles or in the genotypes frequencies of SNPs between groups. In GDM patients, total cholesterol was higher in MM genotype of L55M gene (p < .05); Lp(a) were lower in LM genotype of the gene compared to their respective control (p < .05). In PE, HDL-C levels were higher in LM genotype (p < .05); LDL-C levels were lower in MM genotype of the gene compared to their respective control (p < .05). In PE patients, malondialdehyde(MDA) were higher in QQ genotype compared to their respective control (p < .05). Triglyceride levels were higher in PE patients with QR genotype compared with GDM patients with QR genotype (p < .05). Our results indicated that lipid profiles, Lp(a) and MDA levels showed significant differences in GDM and PE pregnants. These findings support the importance of the lipid profile, oxidized lipid and Lp(a) in different genotypes of L55M and Q192R in Turkish pregnant women with PE/GDM suggesting their roles in etiopathogenesis in these pregnancy-related disorders.

摘要

本研究旨在探讨（氧化酶1）PON1 Q192R和L55M单核苷酸多态性（SNPs）在妊娠期糖尿病（GDM）和先兆子痫（PE）中的作用及其与母体脂质参数水平的关系。本研究纳入GDM孕妇99例, PE孕妇97例, 健康孕妇98例。各组间SNPs等位基因和基因型频率差异无统计学意义。GDM患者为L55M基因的MM基因型, 其总胆固醇较高（p < .05）；与对照组相比, LM基因型的Lp（a）较低（p < .05）。在PE中, LM基因型的HDL-C水平较高（p < .05）；与对照组相比, MM基因型的LDL-C水平较低（p < .05）。在PE患者中, QQ基因型脂质过氧化物（MDA）含量高于对照组（p < 0.05）。与GDM患者相比, QR基因型PE患者甘油三酯水平较高（p < .05）。我们的研究结果表明, GDM和PE孕妇的脂质谱、Lp（a）和MDA水平存在显著差异。这些发现支持了不同基因型（L55M和Q192R）的土耳其PE/GDM孕妇的脂质谱、氧化脂质和Lp(a)的重要性, 提示它们在这些妊娠相关疾病的发病机制中发挥重要作用。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Preeclampsia
• gestational diabetes mellitus
• malondialdehyde
• lipoprotein-a
• lipid profile
• paraoxonase-1 gene
• polymorphism

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was partly supported by the Research Fund of the University of Sakarya. Project numbers are 2013–08-06–006 and 2013–08-06–008.