Could interleukin-33 and its suppressor of tumorigenicity 2 (ST2) receptor have a role in cervical human papillomavirus (HPV) infections?

Abstract

Why most women can clear human papillomavirus (HPV) infections while others can develop permanent infections. The stimulation of immunotolerance of the immune system of the host by the persistent HPV infection may be the answer to this question. Interleukin-33 (IL-33) may play a role in the pathogenesis of HPV infection, this hypothesis was thought to be due to the rapid release of IL-33 from damaged cells following tissue damage, necrosis, and activation of the inflammasome. Thus, in this study, the role of IL-33/suppressor of tumorigenicity 2 (ST2) was emphasized in HPV positive and HPV negative cervical tissues. A total of 80 were assessed. The reduced levels of IL-33 and ST2 are associated with cervical HPV infections. There was a statistically significant 42% positive correlation between IL-33 and ST2 in the HPV-positive group. Surprisingly, our data showed no significant difference between the expression levels of IL-33 or ST2 and working status, type of delivery, pre- and post-operative pathology, cigarette, educational status, locality, birth control method, gynecological, and colposcopic findings. We found that as a result of our study; low IL-33 and ST2 levels were associated with HPV infections

Chinese abstract

为什么大多数女性可以清除人乳头瘤病毒（HPV）感染, 而其他女性可以发展成永久性感染。持续性HPV感染对宿主免疫系统免疫耐受的刺激可能是这个问题的答案。白介素-33（IL-33）可能在人乳头状瘤病毒感染的发病机制中起作用, 这一假说被认为是由于在组织损伤、坏死和炎症体活化后, 受损细胞迅速释放IL-33所致。因此本研究中, 在HPV阳性和HPV阴性的宫颈组织中观察IL33/ ST2抑制剂的作用。共搜集了80例组织标本。IL-33和肿瘤抑制因子（ST2）水平降低与宫颈HPV感染相关。HPV阳性组种42%的标本存在IL-33和ST2与HPV阳性呈显著正相关。令人惊讶的是, 我们的数据显示IL-33或ST2的表达水平与工作状态、分娩类型、术前和术后病理学、吸烟、教育状况、地区、避孕方法、妇科和阴道镜检查结果之间没有显著差异。我们发现, 在我们的研究中, IL-33和ST2水平的降低与HPV感染有关。

Keywords:

• Human papillomavirus
• interleukin-33
• suppressor of tumorigenicity 2 (ST2)
• receptor
• cervical cancer

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the grant from Erzincan University Scientific Research and Project Department.