Improved in vitro fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that had repeated implantation failure history

Abstract

Repeated implantation failure (RIF) due to suboptimal endometrial lining is a major challenge in reproductive medicine. The study aims to evaluate effect of intrauterine platelet-rich plasma (PRP) treatment on frozen-thawed embryo transfer (FET) cycles in patients whose endometrium was unable to achieve optimal lining in unexplained infertility patients with history of RIF. We retrospectively analyzed the charts of a total of 302 cycles performed in 273 patients attending Diyar Life ART Centre between January 2014 and January 2017. After excluding 232 cycles, we compared pregnancy outcomes of 34 patients who had suboptimal endometrial lining and underwent PRP + FET and 36 patients who had optimal endometrial lining and underwent only FET. We observed that, endometrial thickness was higher after 48 hours from PRP when compared to endometrial thickness before PRP (10 mm vs. 6.25 mm, p < .001). Clinical pregnancy rate, and importantly live birth rate were also significantly higher in PRP group than the control group. Based on this information, we showed that intrauterine autologous PRP infusion is a safe, inexpensive adjuvant treatment for optimizing endometrium especially in patients with RIF history and intrauterine PRP infusion improved not only endometrial lining but also in vitro fertilization success and pregnancy outcome.

Chinese abstract

由于次优子宫内膜导致的重复植入失败（RIF）是生殖医学的主要挑战。本研究旨在评估宫内富血小板血浆（PRP）治疗对子宫内膜无法在不明原因不孕症患者中获得最佳内膜的患者的冻融胚胎移植（FET）周期的影响。我们回顾性分析了2014年1月至2017年1月期间参加Diyar Life ART中心的273名患者共执行的302个周期的图表。排除232个周期后, 我们比较了34例子宫内膜不良并接受PRP + FET的患者和36例具有最佳子宫内膜且仅接受FET的患者的妊娠结局。我们观察到, 与PRP前子宫内膜厚度相比, PRP后48小时子宫内膜厚度更厚（10毫米vs 6.25毫米, P < 0.001）。临床妊娠率, 重要的是活产率也明显高于对照组。基于这些信息, 我们发现子宫内自体PRP输注是一种安全、廉价的辅助治疗方法, 可以优化子宫内膜, 尤其是在有RIF病史的患者中, 子宫内PRP输注不仅改善了子宫内膜, 而且改善了体外受精成功率和妊娠结局。

Keywords:

• In vitro fertilization
• live birth rate
• platelet rich plasma
• pregnancy outcome
• repeated implantation failure
• suboptimal endometrium

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Disclosure statement

No potential conflict of interest was reported by the authors.